Pituitary pars intermedia dysfunction (PPID) is a common disease of older equines affecting >25% of animals over the age of 15 years. It has various associated clinical signs that could impact quality-of-life (QoL) including the painful hoof condition laminitis, weight loss and lethargy. Owners frequently mistake some of these clinical signs as being associated with ageing and not important enough to seek veterinary advice. Additionally, owners face increased physical care burden (time, money and physical exertion), along with increased emotional burden such as a changed mental state caused by affected animal encountering challenges that require additional care.

We propose to better define genetic subtypes of canine lymphoma and characterising response to treatment of the different subtypes through a combination of more accurate phenotyping of lymphomas by integrating a) advanced image analysis b) genome sequencing, and c) total RNA sequencing (including micro-RNA sequencing).