Dr Androniki Psifidi
Department: Clinical Science and Services
Campus: Hawkshead
Research Groups: Sustainable Food Systems, Food Safety, Antimicrobial Resistance, Host-Pathogen Interactions and Vaccinology, IRLFS (Research Programme), Musculoskeletal Biology, Cardiovascular and Renal Biology, Comparative Genomics, Endocrinology and Reproduction, CPCS (Research Programme)
Research Centres: RVC Quantitative Biology Resource
Androniki is a Professor in Integrative Veterinary Genetics at RVC. She is a vet and quantitative geneticist interested in the dissection of the genetic architecture and the study of the underlying molecular mechanism of resistance to important animal diseases and zoonoses. For more information see website: https://sites.google.com/view/psifidigroup/home
Androniki is a complex disease geneticist with extensive experience in breeding programmes, quantitative trait analysis, QTL mapping, GWAS, functional genomics, epigenomics, metagenomics, molecular biology and systems biology approaches. After receiving her veterinary degree at the School of Veterinary Medicine of the Aristotle University of Thessaloniki, Greece, she pursued her PhD in quantitative and molecular genetics of scrapie in sheep, funded by the European Commission (FP5 programme), which she completed in 2010. She continued her scientific training as a Postdoctoral Fellow, initially in Greece and then at the Roslin Institute, University of Edinburgh. During her post-doctoral years, she was involved in several successful BBSRC, European Commission and industry funded research projects, aiming to control disease in different species. The outcomes of her work led to new follow-up funding. She joined the faculty at RVC in 2017 as lecturer. In 2021 she was promoted to Senior Lecturer and in 2025 to Professor. Currently, she is leading multiple research projects aiming to develop novel control strategies to improve animal and human health and welfare. For more info see website: https://sites.google.com/view/psifidigroup/home
Since 2005, Androniki has been involved in multiple research projects aiming to dissect the genomic architecture of important animal diseases and zoonoses - in poultry, ruminants and companion animals, enabling the identification of novel disease control strategies to enhance animal and human health and welfare. She integrates her veterinary training with immunology, quantitative and molecular genetics and computational and systems biology approaches in scientific research. She is interested in the discovery of novel biomarkers, the development of breeding and diagnostic tools, the identification of novel drug discovery targets and the use of companion animals as models of human disease.
Androniki's research group implements and integrate classical quantitative genetics with different omics approaches (genomics, transcriptomics, epigenomics, metagenomics) using machine learning and wet-lab approaches to gain better insights in the underlying mechanisms of disease susceptibility.
Androniki is working across different diseases and species. Specifically, she has projects investigating the genetics of zoonoses (campylobacteriosis, salmonellosis, colibacillosis, Avian Influenza), important infectious diseases in poultry (coccidiosis, NDV, fowl typhoid, fowl cholera, Marek’s disease, IBDV), gut health, mastitis and gastrointestinal parasitism in sheep, lameness, bovine respiratory disease and telomere dynamics in relation to health and longevity in cattle, hypertrophic and other cardiomyopathies in cats, B-cell lymphoma in dogs, recurrent exertional rhabdomyolysis, recurrent laryngeal neuropathy and tendinopathies in horses. Furthermore, the group is also working on microRNA discovery and microbiome studies investigating their role in health and productivity.
Current projects include:
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2026-2027: "Factors affecting the calf shed microbiome and its potential relationship with bovine respiratory disease in pre-weaning calves" RVC Launchpad funding scheme. Co-Investigator (£25,000)
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2024-2025: "Characterising the epigenetic landscape of mesenchymal stem cells in relation to tendinopathies and aging" Hong Kong Jockey Club Equine Welfare Research grant. Principal Investigator (£30,849)
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2024: “Effects of incubating broiler eggs under White and Green light upon production parameters and hormones” Internal RVC-Petersime grant. Co-Investigator (£38,008.31)
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2024-2027: “Reducing reliance on ionophores in chickens: Eimeria population biology and impact on selection for antimicrobial resistance” BBSRC-DBT Farmed Animal Disease and Heath Future. Co-Investigator (£837,012)
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2024-2027: "Integrating multi-omics to reveal the genetic risks underlying catastrophic fracture" HBLB Horserace Betting Levy Board. Co-Investigator (£351,758.52)
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2023-2026: "Integrating clinical, data-driven and in-vitro approaches to the study of host- pathogen interactions in bovine digital dermatitis” BBSRC response mode; Joint application between University of Liverpool, SRUC and RVC. RVC Principal Investigator (£565,000; total amount ca £1,500,000)
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2023-2027: “Characterising Enterococcus cecorum and the host response in field broiler chickens” RVC-APHA PhD studentship. Principal Investigator (£126,749.93)
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“Aetiopathogenesis and genetic architecture of recurrent exertional rhabdomyolysis (RER) in UK Thoroughbred horses”. Horserace Betting Levy Board (2023-2026); Principal Investigator; £267,000 plus £500,000 industrial contribution
- “Ovine Respiratory Disease: A Pathway to Prevention” BBSRC Endemic Livestock Disease Priming Partnerships grant application. (2022-2023) Co-Investigator; £249,930
- “Breeders to broilers: optimising chicken health and performance to reduce susceptibility to zoonotic bacteria, viruses, and parasite colonisation” BBSRC iCASE studentship-Moy-Park (2022-2026); Co-Investigator; £205,000
- “Integrating genetics with functional genomics to dissect the genetics of equine exertional rhabdomyolysis” iCASE studentship- Holos Scientific (2022-2025); £310,000
- “A multidisciplinary approach to investigating canine diffuse B-cell lymphoma.” BBSRC iCASE studentship with IDEXX (2022-2026); Co-investigator; £135,000
- “Using ATAC-Seq to shed light in the genetic architecture of equine exertional rhabdomyolysis” Petplan Charitable Trust (2022-2023); Principal Investigator; £15,000
- “Unravelling the genetic mechanisms underlying fracture risk in horses” Honk-Kong Jockey Club Equine Welfare Research Foundation (2022-2024); Co-investigator; £164,851
- “Defining a transcriptomic signature for equine recurrent laryngeal neuropathy” Honk-Kong Jockey Club Equine Welfare Research Foundation (2022-2024); Co-investigator; £169,393
- “Characterisation of Campylobacter infection and gut microbiome composition in chicken under the influences of Eimeria co-infection and/or heat stress.” UKRI GCRF One Health Poultry Hub (OHPH) Pump Priming Award (2022); Co-Investigator; £19,755
- “Capacity building in scientific techniques: identification of selection targets in chickens raised in African village conditions” Global Impact Accelerator Award funded by the Scottish Funding Council GCRF Strategy (2021); Co-investigator; £38,961
- UKRI COVID-19 Extension Allocation funding for the grant entitled “Aetiopathogenesis and genomic architecture of resistance to claw horn disruption lesions in dairy cattle”;(2020-2021) Principal Investigator; £22,862
- “Implementing genome-wide association studies to assess the impact of host genetic variation on enteric microbiome structure and diversity in chickens” One Health Poultry Hub Researcher Mobility Award Application (2021); Host Researcher; £9,600
- “Dissecting Campylobacter-Eimeria co-infections to understand pathogen dynamics and develop a model for future poultry studies” Small Project Research Grant awarded by the Houghton Trust (2020-2022); Principal Investigator; £10,471
- “Understanding the contribution of host genetics, intestinal structure and microbiome diversity to gut health in broiler chickens”. LIDo iCASE PhD Studentship with Cobb Europe Ltd. (2021- 2025); Co-investigator; £162,000
- “Genetic control of hypertrophic cardiomyopathy (HCM) in cats: genomic and transcriptomic characterisation” Petplan Charitable Trust (2022-2025); Principal Investigator; £147,389
- “COVID-19: Lessons in pathophysiology and genetic susceptibility from fatal coronavirus infections in companion animal” UKRI funding for COVID-19 (2020-2022); Co-investigator; £242,000
- “One Health Poultry Hub”; Interdisciplinary Research Hub funded by BBSRC (2019-2024); Co-investigator; £20,489,488
- “Omics based characterisation of host genetics and gut microbiome composition in relation to pathogen abundance in chickens" (2019-2022); main supervisor; £75,000
- “Identification of biomarkers associated with hypertrophic cardiomyopathy (HCM) in cats”; BBSRC Industrial CASE studentship with Zoetis (2019-2023); main supervisor; £157,000
- “Mapping genetic susceptibility to hypertrophic cardiomyopathy in cats and assessing their utility as a disease study model” BBSRC London Interdisciplinary Biosciences PhD Consortium (LIDo) studentship (2018-2022); main supervisor; £82,511
- “Dissecting the genetic architecture of hypertrophy cardiomyopathy in cats” Petplan Charitable Trust (2018); Principal Investigator; £10,000
- “Dissecting the genetic architecture of equine exertional rhabdomyolysis”, Internal RVC PhD studentship (2018-2021); main supervisor; £130,218
- “Identification of genomic markers associated with susceptibility to equine exertional rhabdomyolysis (ER)”, MRes RVC project (2018-2020); main supervisor; £53,380
- ‘Aetiopathogenesis and genomic architecture of resistance to claw horn disruption lesions in dairy cattle’; funded by BBSRC (BBSRC response mode, Joint application of RVC with SRUC and University of Liverpool) (2018-2023); RVC Principal Investigator; £360,994; total amount awarded £1,042,298
- ''SMARTER, SMAll RuminanTs breeding for Efficiency and Resilience''; funded by EU Horizon 2020 (2018-2022); Co-Investigator; £490,000; total amount awarded ca £6,000,000
- ''Identification of selection targets and development of analytical tools to optimise breeding programmes in African chicken populations'' funded by Department for International Development and Bill and Melinda Gates Foundation (2017-2022); Co-Investigator; £800,000
- “The role of interleukin-10 (IL-10) in the regulation of innate immunity in the domestic chicken“, funded by BBSRC (BBSRC Industrial partnering award, Joint application of RVC with Roslin Institute and Cobb-Vantress) (2017-2022); Co-Investigator; £588,280, total amount awarded ca £1,000,000
- “A systems-wide approach to the control of Campylobacter in the food chain: exploiting genetic variation” funded by the Scottish government (2016-2019); Co-Investigator; £500,000
For more details see: https://www.rvc.ac.uk/research/facilities-and-resources/veterinary-clinical-genomics-group
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A. Anagnostopoulos, M. Barden, L. Robinson, N. Siachos, A. Sato, K. Bao, E. Lamprou, A. Gillespie, A. Psifidi, G. Banos, G. Oikonomou. 2025. "A prospective cohort observational study investigating the association between the United Kingdom digital dermatitis genetic index and the disease prevalence in a population of Holstein heifers" J Dairy Sci. In press. doi:10.3168/jds.2025-26440
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K. Ancheta, A. Psifidi, A.D. Yale, S. Le Calvez, J. Williams. 2025. "Deep-Learning Based Morphological Segmentation of Canine Diffuse Large B-cell Lymphoma" Front Vet Sci 12:1656976. doi:10.3389/fvets.2025.1656976
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A. Peiravan, M. Salavati, A. Psifidi, M. Sharman, A. Kent, P. Watson, K. Allenspach, D. Werling. 2025. "Targeted next-generation sequencing of Candidate Regions Identified by GWAS Revealed SNPs Associated with IBD in GSDs" Front Vet Sci 12:1648911. doi:10.3389/fvets.2025.1648911
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T. Liatis, E. Attree, L. Ruiz De Alejos Blanco, P. Santens, A. de Stefani, A. Psifidi. 2025. "Case Report: Phenotypic and genetic characterization of a presumptive sporadic hypothalamic hamartoma in a standard Schnauzer dog" Front Vet Sci 12:1591863. doi:10.3389/fvets.2025.1591863
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D. Meunier, R. Corona-Torres, K. Boulton, Z. Wu, M. Ballantyne, L. Glendinning, A.A. Ahmad, D. Borowska, L. Taylor, L. Vervelde, J. del Pozo, M. Vasilogianni, J. Jaramillo-Ortiz, G. Sanchez-Arsuaga, A. Psifidi, F. Tomley, K. Watson, M.J. McGrew, M.P. Stevens, D.P. Blake, D.A. Hume. 2025. "Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds" eLife 14:RP106252. doi:10.7554/eLife.106252.1
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G. Banos, M. Girma, B. Solomon, P. Davoudi, W. Esatu, T. Dessie, A. Psifidi, K. Watson, O. Hanotte, E. Sánchez-Molano. 2025. "Growth resilience to weather variation in commercial free-ranging chickens in Ethiopia" BMC Genomics 26:371. doi:10.1186/s12864-025-11561-6
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E. Tarsani, B. Li, A. Anagnostopoulos, M. Barden, B.E. Griffiths, C. Bedford, M. Coffey, A. Psifidi, G. Oikonomou, G. Banos. 2025. "Genome-wide association studies of dairy cattle resistance to digital dermatitis recorded at four distinct lactation stages" Sci Rep 15:8922. doi:10.1038/s41598-025-92162-x
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J. Raffle, J.N. Matos, P. Elliott, D.J. Connolly, V. Luis-Fuentes, A. Psifidi. 2025. "Identification of novel genetic variants associated with feline cardiomyopathy using targeted next-generation sequencing" Sci Rep 15:3871. doi:10.1038/s41598-025-87852-5
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A. Hinsu, X. Dai, C. Dadousis, M. Hay, B. Fosso, M. Crotta, R. Pandit, J. Guitian, F. Tomley, P. Koringa, C. Joshi, D. Blake, A.Psifidi. 2025. "Unveiling host-genetic drivers of caecal microbial communities in chickens through Genome Wide Association Studies" Front Microbiomes 4:1539923. doi:10.3389/frmbi.2025.1539923
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G.M. Pangga, B. Star-Shirko, A. Psifidi, D. Xia, N. Corcionivoschi, C. Kelly, C. Hughes, U. Lavery, A. Richmond, U.Z. Ijaz, O. Gundogdu. 2025. "Impact of commercial gut health interventions on caecal metagenome and broiler performance" Microbiome 13:30. doi:10.1186/s40168-024-02012-7
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E. Attree, B. Griffiths, K. Panchal, D. Xia, D. Werling, G. Banos, G. Oikonomou, A. Psifidi. 2024. "Identification of DNA methylation markers for age and Bovine Respiratory Disease in dairy cattle: A pilot study based on Reduced Representation Bisulfite Sequencing" Commun Biol 7:1251. doi:10.1038/s42003-024-06925-9
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W. Zhao, T. Shen, B. Zhao, M. Li, Z. Deng, Y. Huo, B. Aernouts, J.J. Loor, A. Psifidi, C. Xu. 2024. "Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagy" J Animal Sci Biotechnol 15(109). doi:10.1186/s40104-024-01066-9
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V. Lindsay-McGee, C. Massey, Y.T. Li, E.L. Clark, A. Psifidi, R.J. Piercy. 2024. "Characterisation of phenotypic patterns in equine exercise-associated myopathies" Equine Vet J. doi:10.1111/evj.14128
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B.E. Griffiths, M. Barden, A. Anagnostopoulos, J. Wilson, E. Lamprou, W. Tulley, C. Bedford, G. Banos, A. Psifidi and G. Oikonomou. 2024. "A prospective cohort study of factors associated with the digital cushion thickness in dairy cattle" J Dairy Sci. 107(9):7230–7244. doi:10.3168/jds.2023-24563
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K.M. Morris, K. Sutton, M. Girma, E. Sanchez Molano, B. Solomon, W. Esatu, T. Dessie L. Vervelde, A.Psifidi, O. Hanotte, G. Banos. 2024. "Phenotypic and genomic characterisation of performance of tropically adapted chickens raised in smallholder farm conditions in Ethiopia" Front Genet 15. doi:10.3389/fgene.2024.1383609
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A. Kathrani, I. Trewin, K. Ancheta, A. Psifidi, S. Lecalvez, J. Williams. 2024. "A transfer learning approach to intestinal image analysis differentiates treatment response in canine protein-losing enteropathy" Vet Sci 11(3):129. doi: 10.3390/vetsci11030129
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A. Anagnostopoulos, M. Barden, B.E. Griffiths, C. Bedford, M. Winters, B. Li, M. Coffey, A. Psifidi, G. Banos, G. Oikonomou. 2024. "Association between a genetic index for digital dermatitis resistance and the presence of digital dermatitis, heel horn erosion and interdigital hyperplasia in Holstein cows" J Dairy Sci 107(7):4915-4925. doi: 10.3168/jds.2023-24136
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J.M. Lawson, C.A. Shilton, V. Lindsay-McGee, A. Psifidi, D.C. Wathes, T. Raudsepp, A.M. de Mestre. 2024. "Does inbreeding contribute to pregnancy loss in Thoroughbred horses?" Equine Vet J 56(4):711-718. doi: 10.1111/evj.14057
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M.C Hay, A.T. Hinsu, P.G. Koringa, R.J. Pandit, P. Liu, M.J. Parekh, S.J. Jakhesara, X. Dai, M. Crotta, B. Fosso, F.M. Tomley, D. Xia, A. Psifidi, C.G. Joshi, D.P. Blake. 2023. "Chicken caecal enterotypes in indigenous Kadaknath and commercial Cobb chicken lines in western India are associated with Campylobacter abundance and influenced by farming practices" Front Microbiomes 2. doi: 10.3389/frmbi.2023.1301609
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M. Girma, K.M. Morris, K. Sutton, W. Esatu, B. Solomon, T. Dessie, A. Psifidi, L. Vervelde, O. Hanotte, G. Banos and D.P. Malatji. 2023. "Genomic markers associated with antibody response to Newcastle disease virus of Sasso chickens raised in Ethiopia" S Afr J Anim Sci 53(5):728-736. doi: 10.4314/sajas.v53i5.12
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V. Lindsay-McGee, E. Sanchez-Molano, G. Banos, E.L. Clark, R.J. Piercy and A. Psifidi. 2023. "Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach" Genet Sel Evol 55(1):60. doi: 10.1186/s12711-023-00827-w
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B. Li, M. Barden, V. Kapsona, E. Sanchez-Molano, A. Anagnostopoulos, B.E. Griffiths, C. Bedford, X. Dai, M. Coffey, A. Psifidi, G. Oikonomou and G. Banos. 2023. "Single-step genome-wide association analyses of claw horn lesions in Holstein cattle using linear and threshold models" Genet Sel Evol 55(1):16. doi: 10.1186/s12711-023-00784-4
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M. Barden, M.M. Phelan, R. Hyde, A. Anagnostopoulos, B.E. Griffiths, C. Bedford, M. Green, A. Psifidi, G. Banos and G. Oikonomou. 2023. "Serum (1)H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows" J Dairy Sci 106(4):2667-2684. doi: 10.3168/jds.2022-22681
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M. Barden, A. Anagnostopoulos, B.E. Griffiths, B. Li, C. Bedford, C. Watson, A. Psifidi, G. Banos and G. Oikonomou. 2023. "Genetic parameters of sole lesion recovery in Holstein cows" J Dairy Sci 106(3):1874-1888. doi: 10.3168/jds.2022-22064
- Barden Matthew, Li Bingjie, Griffiths Bethany, Anagnostopoulos Alkiviadis, Bedford Cherrill, Psifidi Androniki, Banos Georgios, Oikonomou Georgios (2022) “Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows”. Accepted in Journal of Dairy Science.
- Barden M, Anagnostopoulos A, Griffiths BE, Bedford C, Winters M, Li B, Coffey M, Psifidi A, Banos G, Oikonomou G. “Association between a genetic index for lameness resistance and the incidence of claw horn lesions in Holstein cows.” Vet Rec. 2022 Apr 25:e1632. doi: 10.1002/vetr.1632. Epub ahead of print. PMID: 35468242.
- Christopher Watson, Matthew Barden, Bethany E. Griffiths, Alkiviadis Anagnostopoulos, Helen M. Higgins, Cherrill Bedford, Stuart Carter, Androniki Psifidi, Georgios Banos, Georgios Oikonomou (2022) “Prospective cohort study of the association between early lactation mastitis and the presence of sole ulcers in dairy cows”. VetRecord Volume190, Issue1021/28 https://doi.org/10.1002/vetr.1387
- Jibin Zhang, Ronald M. Goto, Androniki Psifidi, Mark P. Stevens, Robert l. Taylor jr., Marcia M. Miller (2022) Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 61 x Line N) x Line N] population. Poultry Science, Volume 101, Issue 3, 2022, 101654, ISSN 0032-5791, https://doi.org/10.1016/j.psj.2021.101654.
- Benjamin L Makepeace*, Androniki Psifidi*, Diego Robledo*, Dong Xia* (*all authors equally contributed). (2021) Editorial article: “Genetics Architecture and Underlying Molecular Mechanisms in Host- Pathogen Interactions”. Front. Genet. doi: 10.3389/fgene.2021.695109.
- KM. Russell, J. Smith, A. Bremner, C. Chintoan-Uta, L. Vervelde, A. Psifidi & M. P. Stevens. “Transcriptomic analysis of caecal tissue in inbred chicken lines that exhibit heritable differences in resistance to Campylobacter jejuni”. BMC Genomics. 2021; 22: 411. doi: 10.1186/s12864-021-07748-2
- Anagnostopoulos, M. Barden., J. Tulloch, K. Williams, B. Griffiths, C. Bedford, M. Rudd, A. Psifidi, G. Banos, G. Oikonomou. “A study on the use of thermal imaging as a diagnostic tool for the detection of digital dermatitis in dairy cattle”. J Dairy Sci 2021 Jun 4;S0022-0302(21)00650-0. doi: 10.3168/jds.2021-20178
- LA. Seeker, SL. Underwood, RV. Wilbourn, J. Dorrens, R. Holland, JJ. Ilska, A. Psifidi, A. Bagnall, B. Whitelaw, MP. Coffey, G. Banos and DH. Nussey. (2021) “Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle” Scientific Reports 11, 5589 (2021). https://doi.org/10.1038/s41598-021-84984-2
- A. Psifidi, A. Kranis, L.M. Rothwell, A. Bremner, K. Russell, D. Robledo, SJ. Bush, M. Fife, PM. Hocking, G. Banos, D.A. Hume, J. Kaufman, R.A. Bailey, S. Avendano, K.A. Watson, P. Kaiser, M.P. Stevens (2021) “Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter” Scientific Reports 11, 1623 (2021). https://doi.org/10.1038/s41598-020-79005-7
- AL. Denyer, B. Catchpole; LJ. Davison, The Canine Diabetes Genetics Partnership* (2021) “Genetics of canine diabetes mellitus part 1: Phenotypes of disease” The Veterinary Journal DOI: 10.1016/j.tvjl.2021.105611 *I am a member of The Canine Diabetes Genetics Partnership
- AL. Denyer, B. Catchpole; LJ. Davison, The Canine Diabetes Genetics Partnership* (2021) “Genetics of canine diabetes mellitus part 2: Current understanding and future directions” The Veterinary Journal 270(3):105612 DOI: 10.1016/j.tvjl.2021.105612 *I am a member of The Canine Diabetes Genetics Partnership
- G. Banos, V. Lindsay, T.T Desta., J. Bettridge., E. Sánchez-Molano., AV. Trujillo, O. Matika, D. Tadelle, P. Wigley, R. Christley, P. Kaiser, O. Hanotte, A. Psifidi. (2020) “Integrating genetic and genomic analyses of combined health data across ecotypes to 2 improve disease resistance in indigenous African chickens” Frontiers in Genetics DOI: 10.3389/fgene.2020.543890
- C. Chintoan-Uta, T. Wisedchanwet, L. Glendinning, A. Bremner, A. Psifidi, L. Vervelde, K. Watson, M. Watson, MP. Stevens. (2020) “Role of caecal microbiota in the differential resistance of inbred chicken lines to colonization by Campylobacter jejuni”. Applied and Environmental Microbiology 10.1128/AEM.02607-19
- L. Freem, KM. Summers , A. Gheyas, A. Psifidi, K. Boulton, A. McCallum, J. O'Dell, SJ. Bush and D. Hume. (2019) “Analysis of the progeny of sibling matings reveals regulatory variation impacting the transcriptome of immune cells in commercial chickens”, Frontiers in Genetics DOI: 10.3389/fgene.2019.01032.
- JJ. Ilska-Warner*, A. Psifidi*, LA. Seeker, RV. Wilbourn, SL. Underwood, J. Fairlie, B. Whitelaw, DH. Nussey, MP. Coffey, G. Banos (2019) “The genetic architecture of bovine telomere length in early-life and association with animal fitness” Frontiers in Genetics https://doi.org/10.3389/fgene.2019.01048 *equally contributing first authors
- G. Banos, EL. Clark, SJ. Bush, P. Dutta, G. Bramis, G. Arsenos, DA. Hume and A. Psifidi (2019) “Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep”. PLoS One; 14(11): e0214346. 10.1371/journal.pone.0214346
- AT. Hinsu, RJ. Pandit, SH. Patel, A. Psifidi, FM. Tomley, SK. Das, DP. Blake, CG. Joshi. (2019). Genome reconstruction of a novel carbohydrate digesting bacterium from the chicken caecal microflora. Meta Gene 20 (2019)100543
- K. Boulton, MJ. Nolan, Z. Wu, V. Riggio, O. Matika, K. Harman, PM. Hocking, N. Bumstead, P. Hesketh, A. Archer, SC. Bishop, P. Kaiser, FM. Tomley, DA. Hume, AL. Smith, DP. Blake, A. Psifidi. 2018. “Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken”. Frontiers in Genetics;9:528. doi: 10.3389/fgene.2018.00528. eCollection 2018
- K. Boulton, MJ. Nolan, Z. Wu, A. Psifidi, V. Riggio, K. Harman, SC. Bishop, P. Kaiser, MS. Abrahamsen, R. Hawken, KA. Watson, FM. Tomley, DP. Blake, D. Hume. 2018. “Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis”. Genet Sel Evol. 2018;50(1):63. doi: 10.1186/s12711-018-0433-7.
- A. Psifidi, K.M. Russell, O. Matika, E. Sánchez-Molano, P. Wigley, J.E. Fulton, M.P. Stevens, M. Fife. 2018. “The genomic architecture of fowl typhoid resistance in commercial layers”. Frontiers in Genetics | https://doi.org/10.3389/fgene.2018.00519
- J.M Bettridge, A. Psifidi, Z.G. Zerfa, T.T Desta, M. Lozano-Jaramillo, T. Dessie, P. Kaiser, P. Wigley, O. Hanotte, R.M. Christley. 2018 “The role of local adaptation in sustainable production of village chickens” Nature Sustainability-1(10): 574–582. 2018 doi: 10.1038/s41893-018-0150-9
- R. Pandit, A.T. Hinsu, N.V. Patel, P.G. Koringa, S.J. Jakhesara; J.R. Thakkar; T.M. Shah, G. Limon, A. Psifidi, J. Guitian, D.A. Hume, F.M. Tomley, D.N. Rank, M. Raman, Tirumurugaan K G, D.P. Blake, C.G. Joshi. 2018. “Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing” Microbiome20186:115 https://doi.org/10.1186/s40168-018-0501-9
- AT. Hinsu, JR. Thakkar, PG. Koringa, V. Vrba, SJ Jakhesara, A. Psifidi, J. Guitian, FM. Tomley, DN. Rank, M. Raman, CG. Joshi, DP. Blake. 2018. “Illumina next generation sequencing for the analysis of Eimeria populations in commercial broilers and indigenous chickens”. Frontiers in Veterinary Science. 5:176. doi: 10.3389/fvets.2018.00176. eCollection 2018. PMID: 30105228.
- RA. Bailey, A. Kranis, A. Psifidi, L. Rothwell, P. Hocking, KA. Watson, P. Kaiser, MP. Stevens, S. Avendano. 2018. “Genetic basis of Campylobacter colonisation in the broiler chicken and its impact on intestinal health following natural field exposure” Poultry Science, pey295, https://doi.org/10.3382/ps/pey295.
- S.J. Bush, L. Freem, A.J. MacCallum, J. O’Dell, C. Wu, C. Afrasiabi, A. Psifidi, M.P. Stevens, J. Smith, K.M. Summers, D.A. Hume. 2018. “Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken” BMC Genomics (2018) 19:594 DOI https://doi.org/10.1186/s12864-018-4972-7
- J. Ioannidis, E. Sánchez-Molano, A. Psifidi, F. X. Donadeu and G. Banos. 2018. “Association of plasma microRNA expression with age, genetic background and functional traits in dairy cattle” Scientific Reports, 8(1), 12955. https://doi.org/10.1038/s41598-018-31099-w
- L. Seeker, J. Ilska, A. Psifidi, R. Wilbourn, S. Underwood, J. Fairlie, R. Holland, H. Froy, E. Salvo-Chirnside, A. Bagnall, B. Whitelaw, M. Coffey, D. Nussey, G. Banos. 2018. "Bovine telomere dynamics and the association between telomere length and productive lifespan" Scientific Reports (2018) 8:12748 DOI:10.1038/s41598-018-31185-z 4
- R.J. Pandit, A.T. Hinsu, S.H. Patel, S.J. Jakhesara, P.G. Koringa, F. Bruno, A. Psifidi, S.V. Shah, C.G. Joshi. 2018."Microbiota composition, gene pool and its expression in Gir cattle (Bos indicus) rumen under different forage diet using metagenomic and metatranscriptomic approach" Systematic and Applied Microbiology 41 (2018) 374–385- https://doi.org/10.1016/j.syapm.2018.02.002
- L.A. Seeker, J.J. Ilska, A. Psifidi, R.V. Wilbourn, S.L. Underwood, J. Fairlie, R. Holland, H. Froy, A. Bagnall, B. Whitelaw, M. Coffey, D.H. Nussey, G. Banos. 2018. "Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models". PLoS ONE 13(2): e0192864. https://doi.org/10.1371/journal.pone.0192864
- G. Banos, G. Bramis, S.J. Bush, E.L. Clark, M.B. McCulloch, J. Smith, G. Schulze, G. Arsenos, D.A. Hume, A. Psifidi.2017. “The genomic architecture of mastitis resistance in dairy sheep” BMC Genomics 18:624 doi: 10.1186/s12864-017-3982-1.
- D. Miltiadou, A.L. Hager-Theodorides, S. Symeou, C. Constantinou, A. Psifidi, G. Banos, O. Tzamaloukas. 2017. “Variants in the 3'UTR of the ovine Acetyl-Coenzyme A Acyltransferase 2 gene are associated with dairy traits and exhibit differential allelic expression”. Journal of Dairy Science 100:8:6285-6297. DOI:https://doi.org/10.3168/jds.2016-12326
- L.A. Seeker, R. Holland, S. Underwood, J. Fairlie, A. Psifidi, J.J. Ilska, A. Bagnall, B. Whitelaw, M. Coffey, G. Banos and D.H. Nussey. 2016. “Method specific calibration corrects for DNA extraction method effects on relative telomere length measurements by quantitative PCR” PLos One -https://dx.doi.org/10.1371/journal.pone.0164046
- A. Psifidi, G. Banos, O. Matika, T.T. Desta, J. Bettridge, D.A. Hume, D. Tadelle, R. Christley, P. Wigley, O. Hanotte and P. Kaiser. 2016. “Genome-wide association studies of immune, disease and productivity traits in indigenous chicken ecotypes” Genetic Selection Evolution 48:74 DOI: 10.1186/s12711-016-0252-7
- A. Psifidi, M. Fife, J. Howell, O. Matika, P. M. van Diemen, R. Kuo, J. Smith, P.M. Hocking, N. Salmon, M.A. Jones, D.A. Hume, G. Banos, M.P. Stevens and P. Kaiser. 2016. “The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens” BMC Genomics 201617:293, DOI: 10.1186/s12864-016-2612-7
- A. Psifidi, C.I. Dovas, G. Bramis, T. Lazou, C.L. Russel, G. Arsenos and G. Banos. 2015. “Comparison of eleven methods for genomic DNA extraction suitable for large-scale whole-genome genotyping and long-term DNA banking using blood samples” PLoS ONE 10(1): e0115960. doi:10.1371/journal.pone.0115960.
- A. Psifidi, C.I. Dovas, K. Efthimiou and G. Banos. 2013. “PRNP genotyping in dairy sheep flocks: A sampling strategy for application in breeding programmes for scrapie eradication" Small Ruminant Research 113:335-339.
- A.I. Gelasakis, G. Arsenos, J. Hickford, H. Zhou H., A. Psifidi, G.E. Valergakis and G. Banos. 2013. “Polymorphism of the MHC-DQA2 gene in the Chios dairy sheep population and its association with footrot” Livestock Science http://dx.doi.org/10.1016/j.livsci.2013.02.011i.
- A. Psifidi, Z. Basdagianni, C.I. Dovas, G. Arsenos, E. Sinapis, M. Papanastassopoulou and G. Banos. 2011. “Characterisation of the PRNP gene locus in Chios dairy sheep and its association with milk production and reproduction traits” Animal Genetics 42:406-414.
- A. Psifidi, C.I. Dovas and G. Banos. 2011. “Novel quantitative real-time LCR for the sensitive detection of SNP frequencies in pooled DNA: Method development, evaluation and application” PLoS ONE 6(1): e14560. doi:10.1371/journal.pone.0014560.
- A. Psifidi, C.I. Dovas and G. Banos. 2010. “A comparison of six methods for genomic DNA extraction suitable for PCR-based genotyping applications using ovine milk samples” Molecular and Cellular Probes 24:93-98.
- b.Full articles in refereed scientific conference proceedings
- X. Dai, D. Xia, B. E. Griffiths, A. Anagnostopoulos, M. Barden, B. Li, M. Coffey, D. Werling, G. Oikonomou, G. Banos, and A. Psifidi (2022)”Transcriptomic characterisation of claw horn disruption lesions in the peripheral blood leucocytes of dairy cattle”. Proceedings of the 12th World Congress on Genetics Applied to Livestock Production, Rotterdam, The Netherlands
- X. Dai, A. T. Hinsu, C. Dadousis, R. J. Pandit, M. Crotta, G. Limon, B. Fosso, J. Guitian, F. M. Tomley, P. G. Koringa, C. G. Joshi, D. P. Blake and A. Psifidi (2022)“Genome-wide association studies of chicken caecal microbiota” Proceedings of the 12th World Congress on Genetics Applied to Livestock Production, Rotterdam, The Netherlands
- B. Li, M. Barden, V. Kapsona, E.S. Molano, A. Anagnostopoulos, B.E. Griffiths, C. Bedford, X. Dai, M. Coffey, A. Psifidi, G. Oikonomou, and G. Banos (2022)“Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle”. Proceedings of the 12th World Congress on Genetics Applied to Livestock Production, Rotterdam, The Netherlands
- K.M. Morris, K. Sutton, M. Girma, W. Esatu, B. Solomon, T. Dessie, L. Vervelde, A. Psifidi, O. Hanotte and G. Banos (2022) “Phenotypic characterisation of African chickens raised in semi scavenging conditions. Proceedings of the 12th World Congress on Genetics Applied to Livestock Production, Rotterdam, The Netherlands
- A. Psifidi, M. Crotta, RJ. Pandit, B. Fosso, PG. Koringa, G Limon, K. Boulton, G. Banos, J Guitian, FM. Tomley, DN. Rank, CG. Joshi, D. Hume, DP. Blake. 2018. “Identification of SNP markers affecting gut microbiome composition in chicken”. Proceedings of the 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand
- J.J. Ilska*, A. Psifidi*, L.A. Seeker, B. Whitelaw, M. Coffey, D. Nussey, G. Banos. 2018. “Genetic background of early life telomere length and association with dairy cow longevity”. Proceedings of the 10th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand (* equally contributed first authors)
- A. Psifidi, M. Fife, O. Matika, K. Boulton, G. Banos, D. Blake, DA. Hume, MP. Stevens, P. Kaiser. 2017. “Mapping disease resistance in poultry”. Invited speech, Proceedings of the 10th European Symposium of Poultry Genetics, 26th-28th June, St Malo, France
- 48. A. Psifidi, G. Bramis, G. Arsenos and G. Banos. 2014. “Genetic Parameters and Genomic Markers Associated with Mastitis Resistance in Dairy Sheep” Proceedings of the 10th World Congress on Genetics Applied to Livestock Production, Vancouver BC, Canada, 521
- A. Psifidi, G. Banos, O. Matika, T. Dessie, R. Christley, P. Wigley, J. Bettridge, O. Hanotte, T. Desta and P. Kaiser. 2014. “Identification of SNP Markers for Resistance to Salmonella and IBDV in Indigenous Ethiopian Chickens” Proceedings of the 10th World Congress on Genetics Applied to Livestock Production, Vancouver BC, Canada, 321.
- A. Psifidi, C.I. Dovas, G. Arsenos, M. Papanastassopoulou, Z. Basdagianni and G. Banos. 2010. “Detection and Quantification of PrP Alleles Based on Flock Bulk Milk of Dairy Ewes Using Gap-A Ligase Chain Reaction“. Proceedings of the 9th World Congress on Genetics Applied to Livestock Production, CD-ROM communication 0086. Leipzig, Germany.
- A.I. Gelasakis, G. Arsenos, J.G. Hickford, A. Psifidi, H. Zhou and G. Banos. 2010. “Polymorphism of the DQA2 gene in the Chios Dairy sheep population and its association with footrot“. Proceedings of the 9th World Congress on Genetics Applied to Livestock Production, CD-ROM communication 0631. Leipzig, Germany.
- c. Lay publication
- V. Lindsay, A. Psifidi, R. Piercy (2021) “What is tying-up” Lay article in the magazine: Your Horse-published March 2021.
- d.Chapters in books
- A. Psifidi, Royal Veterinary College, UK. (2021) Chapter: “Genetics of Disease Resistance” in the book entitled: “Poultry Health A Guide for Professionals” Edited by Paul Barrow, Venugopal Nair, Susan Baigent, Robert Atterbury and Michael Clark published by CABY.
- M.-H. Pinard-van der Laan, INRAE, France; J. Kaufman, University of Edinburgh and University of Cambridge, UK; A. Psifidi, Royal Veterinary College, UK; H. Zhou, University of California-Davis, USA; and M. Fife, Aviagen Ltd and The Pirbright Institute, UK (2020) Chapter: “Genetics and genomics of immunity and disease traits in poultry species”, in the book entitled : “Advances in poultry genetics and genomics” Ed. : S.E. Aggrey, H. Zhou, M. Tixier-Boichard, D.D. Rhoads Pub. : Burleigh Dodds series in agricultural science, Burleigh Dodds Science Publishing Limited, Cambridge, UK published by the Burleigh Dodds Science Publishing. Relevant link: https://shop.bdspublishing.com/store/bds/detail/workgroup/3-190-83999
Androniki teaches animal breeding and genetics, and genetics of disease in BVetMed students.
She supervises and co-supervises several PhD, MSci and MRes students within the field of genetics, genomics, functional genomics and metagenomics of complex disease resistance. Androniki also supervises undergraduate (RP2 and BSciYear3) research projects.
RVC SEPTEMBER SHOWCASE
This September the RVC hosted a showcase event at the Hawkshead campus for the first time in almost 20 years! On the day we welcomed onto campus over 400 visitors specifically for the showcase, as well as another 200 from a combination of open house, alumni and incoming vet nurse visitors. We had a stand showcasing both the work that we do across all our research projects alongside interactive games and activities for visitors to do while learning about genetics! We were also able to run two sessions on extracting DNA from a strawberry or kiwi which were really well attended, with almost 60 adults and children across the two sessions. Those who took part really enjoyed the DNA extraction and we had great engagement on our stand from kids and parents learning all about genetics/genomics and what we do! It was a very successful day and everyone who took part from the lab had a brilliant time!
RVC'S NIGHT AT THE VET COLLEGE
On Wednesday 13th November 2024 our lab took part in the RVC's Night at the Vet College event at the Camden campus, where members of the public attend the university to gain a better insight into the courses and research that happens at the university! We were on a joint Genomics and Machine Learning stand with representatives from Dong Xia's lab.
From our lab we were represented by Androniki, Lizzie, Ankit, Charlotte and Kat, who all spent time manning the stand! We had posters showcasing our work across species and countries and leaflets highlighting ways people can get involved with our cat and horse research projects. We had some matching games highlighting mendelian inheritance and chromosome karyotyping, as well as a crafting activity to make dna and rna using pipe cleaners and beads. We had many people visiting the stand to talk to us about the research we do and engaging in the games we had organised. It was a very successful evening and we all reenjoyed ourselves!
SKYSWOOD PRIMARY & NURSERY SCHOOL
The labteam visited year 3 and year 5 students of Skyswood Primary school in St. Albans. The team discussed about the career in biological science, what it means to be a scientist and motivated the young students to become scientists. The team organised different genetics/genomics focussed activities for students. The students enjoyed extracting DNA from fruits and creating DNA models from sweets while understanding the basics of genetics.
Year 5 welcomes Royal Veterinary College! – Skyswood Primary & Nursery School
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A Multi-disciplinary Approach to Investigating Canine Diffuse Large B cell Lymphoma
We propose to better define genetic subtypes of canine lymphoma and characterising response to treatment of the different subtypes through a combination of more accurate phenotyping of lymphomas by integrating a) advanced image analysis b) genome sequencing, and c) total RNA sequencing (including micro-RNA sequencing).
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Genetic and non-genetic factors in Campylobacter levels in poultry
Researchers explored variation at specific positions in chickens’ genome and their association with Campylobacter in the birds’ guts. Campylobacteriosis exerts profound societal and economic costs to the UK and other countries. The World Health Organization has estimated that Campylobacter causes 95 million illnesses, 21,000 deaths and loss of 2.1 million disability-adjusted life years globally. In the UK alone, there were 63,946 laboratory-confirmed human cases in 2017.
The study concluded that, although there are genetic factors that influence Campylobacter colonisation, these factors play a relatively minor role.
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Integrating genetics with functional genomics to dissect the aetiopathogenesis of equine exertional rhabdomyolysis
Equine exertional rhabdomyolysis (ER) is a syndrome involving painful, exercise induced episodes of muscle stiffness and acute myonecrosis which can result in renal failure and in severe cases, death.
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SweetAnimals
The SweetAnimal project studies the presence of sugar-binding receptors in the genomes of a variety of farmed animals, how these differ between species, what ligands expressed on pathogens they bind, and how this information can be used to develop carbohydrate-based vaccines.
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UK Research and Innovation (UKRI) Global Challenges Research Fund (GCRF) One Health Poultry Hub
With integrated streams of social, economic, biological, mathematical and policy-led research, we are co-producing detailed knowledge on the biological, structural and socio-economic factors that shape networks of chicken production and distribution. The RVC-led UKRI GCRF One Health Poultry Hub brings together leading laboratory, clinical, veterinary and social scientists, as well as skilled communications experts, programme support staff and external stakeholders.
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Understanding the genetic basis of catastrophic bone fracture in Thoroughbred horses using stem cells.
Bone fractures are a significant welfare problem in the Thoroughbred racing industry. Previous work has demonstrated that fracture is a complex condition with both environmental and genetic factors risk factors. However, the specific genetic factors that underpin fracture risk have not been identified. This has proved problematic to work out using patients due to the difficulty in accessing bone tissue and the large variability in exposure to environmental risk factors.
