Department: Clinical Science and Services

Campus: Hawkshead

Research Groups: Musculoskeletal Biology

Clinical Groups: Equine Surgery

Roger is Professor of Equine Orthopaedics at the Royal Veterinary College (RVC). He currently divides his time equally between running a specialist orthopaedic service within the RVC and continuing to direct research into equine tendon disease

He qualified as a veterinary surgeon from Cambridge University in 1987 and, after 2 years in practice, returned to academia to undertake further clinical training as a Resident in Equine Studies at the Royal Veterinary College. Following his residency, he undertook a 3 year research project culminating in the award of a PhD for his studies on the extracellular matrix of equine tendon. He remained at the Royal Veterinary College, first as a Lecturer in Equine Surgery, then as Senior Lecturer in Equine Surgery before his appointment to a Professorship in December 2003

Roger’s main area of research is understanding the mechanisms of tendon ageing. He also has projects investigating the epidemiology of tendon disease in the horse, the development of a serological assay for tendonitis, and stem cell therapy for tendons in conjunction with a commercial company, VetCell Bioscience Ltd.

Dakin SG, Werling D, Hibbert A, Abayasekara DR, Young NJ, Smith RK, Dudhia J. Macrophage Sub-Populations and the Lipoxin A(4) Receptor Implicate Active Inflammation during Equine Tendon Repair. PLoS One. 2012;7(2):e32333. Epub 2012 Feb 22.

Caniglia CJ, Schramme MC, Smith RK. The effect of intralesional injection of bone marrow derived mesenchymal stem cells and bone marrow supernatant on collagen fibril size in a surgical model of equine superficial digital flexor tendonitis. Equine Vet J. 2011 Epub Dec 11.

Smith RK, McIlwraith CW. Consensus on equine tendon disease: Building on the 2007 Havemeyer symposium. Equine Vet J. 2012 Jan;44(1):2-6.

Godwin EE, Young NJ, Dudhia J, Beamish IC, Smith RK. Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon. Equine Vet J. 2012 Jan;44(1):25-32.

Dakin SG, Jespers K, Warner S, O'Hara LK, Dudhia J, Goodship AE, Wilson AM, Smith RK. Therelationship between in vivo limb and in vitro tendon mechanics after injury: A potential novel clinical tool for monitoring tendon repair. Equine Vet J. 2011 Jul;43(4):418-23.

Kasashima Y, Ueno T, Tomita A, Goodship AE, Smith RK. Optimisation of bone marrow aspiration from the equine sternum for the safe recovery of mesenchymal stem cells. Equine Vet J. 2011 May;43(3):288-94.

Jordana M, Wilderjans H, Boswell J, Dewulf J, Smith RK, Martens A. Outcome after lacerations of the superficial and deep digital flexor tendons, suspensory styleligament and/or distal sesamoidean ligaments in 106 horses. Vet Surg. 2011 May;40(3):277-83.

Crawford A, O'Donnell M, Crowe O, Eliashar E, Smith RK. Digital sheath synovial ganglion cysts in horses. Vet Surg. 2011 Jan;40(1):66-72.

Smith MR, Wright IM, Minshall GJ, Dudhia J, Verheyen K, Heinegård D, Smith RK. Increased Cartilage Oligomeric Matrix Protein Concentrations in Equine Digital Flexor Tendon Sheath Synovial Fluid Predicts Intrathecal Tendon Damage. Vet Surg. 2010 40(1):54-8.

Dart AJ, Dart CM, Dudhia J, Perkins N, Canfield P, Smith RK. A Preliminary Study on the Effect of Wounding on Transforming Growth Factor-β1 and Cartilage Oligomeric Matrix Protein Concentrations in the Skin of Horses. Vet Surg. 2011 Jan;40(1):59-65.

Fiske-Jackson AR, Crawford AL, Archer RM, Bolt DM, Smith RK. Diagnosis, Management, and Outcome in 19 Horses with Deltoid Tuberosity Fractures. Vet Surg. 2010 Dec;39(8):1005-10.

Lui PP, Maffulli N, Rolf C, Smith RK. What are the validated animal models for tendinopathy? Scand J Med Sci Sports. 2011 Feb;21(1):3-17.

Gough MR, Thibaud D, Smith RK. Tiludronate infusion in the treatment of bone spavin: a double blind placebo-controlled trial. Equine Vet J. 2010 Jul;42(5):381-7.

Posthumus M, Collins M, Cook J, Handley CJ, Ribbans WJ, Smith RK, Schwellnus MP, Raleigh SM. Components of the transforming growth factor-{beta} family and the pathogenesis of human Achilles tendon pathology--a genetic association study. Rheumatology (Oxford). 2010 Nov;49(11):2090-7.

Crowe OM, Hepburn RJ, Kold SE, Smith RK. Long-term outcome after arthroscopic debridement of distal phalanx extensor process fragmentation in 13 horses. VetSurg. 2010 Jan;39(1):107-14.

Frisbie DD, Smith RK. Clinical update on the use of mesenchymal stem cells in equine orthopaedics. Equine Vet J. 2010 Jan;42(1):86-9.

Smith RK. 'Can you regain your youth?'--the real potential of stem cell technology. Equine Vet J. 2010 Jan;42(1):2-4.

Avella CS, Ely ER, Verheyen KLP, Price JS, Wood JLN, Smith RKW Ultrasonographic assessment of the superficial digital flexor tendons of National Hunt racehorses in training over two racing seasons. Equine Vet J. 2009 May; 41(5): 449-454.

Raleigh SM, Van der Merwe L, Ribbans WJ, Smith RK, Schwellnus MP, Collins M. Variants within the MMP3 gene are associated with Achilles tendinopathy: Possible interaction with the COL5A1 gene. Br J Sports Med. 2009 43(7):514-20

Smith RK. Mesenchymal stem cell therapy for equine tendinopathy. Disabil Rehabil. 2008;30(20-22):1752-8.

Fortier LA, Smith RK. Regenerative medicine for tendinous and ligamentous injuries of sport horses. Vet Clin North Am Equine Pract. 2008 Apr;24(1):191-201.

Smith RK, Goodship AE. The effect of early training and the adaptation and conditioning of skeletal tissues. Vet Clin North Am Equine Pract. 2008 Apr;24(1):37-51.

Moffat PA, Firth EC, Rogers CW, Smith RK, Barneveld A, Goodship AE, Kawcak CE, McIlwraith CW, van Weeren PR. The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young Thoroughbred horses. Equine Vet J. 2008 Mar;40(2):136-40.

Kasashima Y, Takahashi T, Birch HL,Smith RK, Goodship AE. Can exercise modulate the maturation of functionally different immature tendons in the horse? J Appl Physiol. 2008 Feb;104(2):416-22. Epub 2007 Dec 13.

Hughes TK, Eliashar E, Smith RK. In vitro evaluation of a single injection technique for diagnostic analgesia of the proximal suspensory ligament of the equine pelvic limb. Vet Surg. 2007 Dec;36(8):760-4.

Dudhia J, Scott CM, Draper ER, Heinegård D, Pitsillides AA, Smith RK. Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity. Aging Cell. 2007 Aug;6(4):547-56.

Smith MR, Wright IM, Smith RK. (2007) Endoscopic assessment and treatment of lesions of the deep digital flexor tendon in the navicular bursae of 20 lame horses. Equine Vet J. 39: 18-24.

Smith R.K., Dyson S.J., Schramme M.C., Head M.J., Payne R.J., Platt D., and Walmsley J. (2005) Osteoarthritis of the talocalcaneal joint in 18 horses. Equine Vet J., 37, 166-171.

Smith MRW, Crowe OC, Ellson C, Turner SJ, Patterson-Kane JC, Schramme MC, and Smith RKW (2005) Surgical treatment of osseous cyst-like lesions in the distal phalanx arising from collateral ligament insertional injury. Equine Veterinary Educationstyle 17 (4) 195-200.

Smith M.A., Walmsley J.P., Phillips T.J., Pinchbeck G.L., Booth T.M., Greet T.R.,Richardson D.W., Ross M.W., Schramme M.C., Singer E.R., Smith R.K., and Clegg P.D. (2005) Effect of age at presentation on outcome following arthroscopic debridement of subchondral cystic lesions of the medial femoral condyle: 85 horses (1993--2003). Equine Vet J., 37, 175-180.

Goodman SA, May SA, Heinegard D, and Smith RK. (2004) Tenocyte response to cyclical strain and transforming growth factor beta is dependent upon age and site of origin. Biorheology. 2004;41(5):613-28.

Kasashima Y, Takahashi T, Smith RK, Goodship AE, Kuwano A, Ueno T, and Hirano S. (2004) Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999. Equine Vet J., 36, 346-350.

Crowe OM, Dyson SJ, Wright IM, Schramme MC, and Smith RK. (2004) Treatment of chronic or recurrent proximal suspensory desmitis using radial pressure wave therapy in the horse. Equine Vet J., 36, 313-316.

Johnson, A., Smith, R.K.W., Saxne, T., Hickery, M., and Heinegård, D. (2003) Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant Osteoarthritis and Rheumatism, 12, 149-159.

Post, E., Smith, R.K.W., Clegg, P.D., Proudman, C., and Singer, E. (2003) A retrospective study of 24 cases of septic calcaneal bursitis in the Equine Vet J, 35, 662-668.

Smith, R.K., Korda, M., Blunn, G.W., and Goodship, A.E. (2003) Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment. Equine Vet J, 35, 99-102

Smith, R.K., Birch, H.L., Goodman, S., Heinegard, D., and Goodship, A.E. (2002) The influence of ageing and exercise on tendon growth and degeneration-hypotheses for the initiation and prevention of strain-inducedtendinopathies. Comp Biochem Physiol A Mol Integr Physiol, 133, 1039-50

Smith, R.K.W., McGuigan, M.P., Hyde, J.T., Daly, A.S.G., Pardoe, C.H., Lock, A.N., and Wilson, A.M. (2002) In vitro evaluation of non-rigid support systems for the equine metacarpophalangeal joint. Equine vet J., 34, 726-31.

Smith, R.K.W., Gerard, M., Dowling, B., Dart, A.J., Birch, H.L., and Goodship, A.E. (2002) Correlation of Cartilage Oligomeric Matrix Protein (COMP) levels in equine tendon with mechanical properties – a proposed role for COMP in determining function-specific mechanical characteristics of locomotor Equine vet. J., Suppl. 34, 241-244..

Smith, R.K.W. and Heinegård, D. (2000) Cartilage Oligomeric Matrix Protein levels in digital sheath synovial fluid and serum with tendon injury. Equine vet. J., 32, 52-58.

Dowling, B.A., Dart, A.J., Hodgson, D.R., and Smith, R.K. (2000) Superficial digital flexor tendonitis in the horse. Equine vet. J., 32, 369-378.

Smith, R.K.W., Birch, H., Patterson-Kane J., Firth, E.C., Williams, L., Cherdchutham, W., van Weeren R., and Goodship, A.E. (1999) Should equine athletes commence training during skeletal development? - changes in tendonmatrix associated with development, ageing, function, and Equine vet. J., Suppl. 30, 201-209.

Smith, R.K.W., Zunino, L., Webbon, P.M., and Heinegård, D. (1997) The distribution of cartilage oligomeric matrix protein (COMP) in tendon and its variation with tendon site, age, and Matrix Biol., 16, 255-271.

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