Department: Pathobiology and Population Sciences
Brian is Professor of Companion Animal Immunology. He is a veterinary clinical research scientist, whose research involves studying canine immunology and immunogenetics in relation to immune-mediated diseases and vaccine responses.
Brian graduated from the Royal Veterinary College in 1992. After spending 3 years in veterinary small animal practice, he returned to the RVC to study for a PhD in immunology in collaboration with the Infection & Immunity Research group, King’s College London. Following a period as a Research Fellow, Brian was appointed as Lecturer in Veterinary Immunology in 2001 before becoming a Senior Lecturer in 2006 and promoted to Professor in 2014.
Brian’s research interests centre around canine immunology and immunogenetics in relation to susceptibility to immune-mediated diseases and response to vaccination. Brian is currently investigating canine endocrine disease, more specifically working to understand the pathogenesis of diabetes mellitus, hypothyroidism and hypoadrenocorticism in dogs. In particular, identifying dogs with Type 1 (immune-mediated) diabetes and performing genetic analysis for potential susceptibility genes (QMHA Clinical Trials).
Brian is currently involved in cancer immunotherapy; developing therapeutic DNA vaccines for canine malignant melanoma and mast-cell tumours, designed to stimulate an immune response to associated antigens for treatment of metastatic disease.
Brian is also involved in a study characterising canine innate immune response genes to determine whether these are involved in susceptibility to various disease syndromes (including anal furunculosis and inflammatory bowel disease). Alongside this, Brian is also examining the genetics of vaccine responses in dogs; how immune response genes can influence the response to vaccination and how immunosenescence impacts on the immune response as dogs get older.
Serological testing for canine Addison’s disease
Addison’s disease (hypoadrenocorticism) is an autoimmune condition that occurs in dogs when the immune system attacks and destroys the adrenal gland, leading to a deficiency of steroid hormones.
We are interested in the genetics and autoimmune response in canine Addison’s disease and have identified autoantibodies in the blood that react to proteins in the adrenal gland. We are interested in carrying out further research into this disease, to measure these autoantibodies, to see whether they can be used as part of diagnostic testing and potentially to identify dogs that have an autoimmune reaction, before they develop clinical signs. We are keen to recruit dogs that are undergoing blood sampling as part of diagnostic testing for Addison’s disease or who are being monitored for their response to steroid replacement therapy.
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TIVERS, M. S., CATCHPOLE, B., GREGORY, S. P. & HOUSE, A. K. (2008) Interleukin-2 and interferon-gamma mRNA expression in canine anal furunculosis lesions and the effect of ciclosporin therapy. Vet Immunol Immunopathol. PubMed ID 18541310
KENNEDY, L. J., O'NEILL, T., HOUSE, A., BARNES, A., KYOSTILA, K., INNES, J., FRETWELL, N., DAY, M. J., CATCHPOLE, B., LOHI, H. & OLLIER, W. E. (2008) Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens 71, 51-56. PubMed ID 17999655
HOUSE, A. K., GREGORY, S. P. & CATCHPOLE, B. (2008) Pattern-recognition receptor mRNA expression and function in canine monocyte/macrophages and relevance to canine anal furunuclosis. Vet Immunol Immunopathol 124, 230-240. PubMed ID 18471895
CATCHPOLE, B., MOUNTFORD, S., BARABAS, S. & SCARAMUZZI, R. J. (2008) Evaluation of a disposable device for the measurement of haemoglobin A1c in dogs. Vet Rec 162, 47-49. PubMed ID 18192656
SHORT, A. D., CATCHPOLE, B., KENNEDY, L. J., BARNES, A., FRETWELL, N., JONES, C., THOMSON, W. & OLLIER, W. E. (2007) Analysis of candidate susceptibility genes in canine diabetes. J Hered 98, 518-525.
KENNEDY, L. J., BARNES, A., SHORT, A., BROWN, J. J., SEDDON, J., FLEEMAN, L., BRKLJACIC, M., HAPP, G. M., CATCHPOLE, B. & OLLIER, W. E. (2007) Canine DLA diversity: 3. Disease studies. Tissue Antigens 69 Suppl 1, 292-296. PubMed ID 17445220
HOUSE, A. K., CATCHPOLE, B. & GREGORY, S. P. (2007) Matrix metalloproteinase mRNA expression in canine anal furunculosis lesions. Vet Immunol Immunopathol 115, 68-75. PubMed ID 17125846
KENNEDY, L. J., QUARMBY, S., HAPP, G. M., BARNES, A., RAMSEY, I. K., DIXON, R. M., CATCHPOLE, B., RUSBRIDGE, C., GRAHAM, P. A., HILLBERTZ, N. S., ROETHEL, C., DODDS, W. J., CARMICHAEL, N. G. & OLLIER, W. E. (2006) Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele. Tissue Antigens 68, 82-86. PubMed ID 16774545
KENNEDY, L. J., DAVISON, L. J., BARNES, A., SHORT, A. D., FRETWELL, N., JONES, C. A., LEE, A. C., OLLIER, W. E. & CATCHPOLE, B. (2006) Identification of susceptibility and protective major histocompatibility complex haplotypes in canine diabetes mellitus. Tissue Antigens 68, 467-476. PubMed ID 17176436
RISTIC, J. M., HERRTAGE, M. E., WALTI-LAUGER, S. M., SLATER, L. A., CHURCH, D. B., DAVISON, L. J. & CATCHPOLE, B. (2005) Evaluation of a continuous glucose monitoring system in cats with diabetes mellitus. J Feline Med Surg 7, 153-162. PubMed ID 15922222
HABIBAH, A., CATCHPOLE, B. & BOND, R. (2005) Canine serum immunoreactivity to M. pachydermatis in vitro is influenced by the phase of yeast growth. Vet Dermatol 16, 147-152. PubMed ID 15960626
DAVISON, L. J., HERRTAGE, M. E. & CATCHPOLE, B. (2005) Study of 253 dogs in the United Kingdom with diabetes mellitus. Vet Rec 156, 467-471. PubMed ID 15828742
CATCHPOLE, B., RISTIC, J. M., FLEEMAN, L. M. & DAVISON, L. J. (2005) Canine diabetes mellitus: can old dogs teach us new tricks? Diabetologia 48, 1948-1956. PubMed ID 16151773
HOUSE, A., GREGORY, S. P. & CATCHPOLE, B. (2003) Expression of cytokine mRNA in canine anal furunculosis lesions. Vet Rec 153, 354-358. PubMed ID 14533766
DAVISON, L. J., SLATER, L. A., HERRTAGE, M. E., CHURCH, D. B., JUDGE, S., RISTIC, J. M. & CATCHPOLE, B. (2003) Evaluation of a continuous glucose monitoring system in diabetic dogs. J Small Anim Pract 44, 435-442. PubMed ID 14582657
DAVISON, L. J., RISTIC, J. M., HERRTAGE, M. E., RAMSEY, I. K. & CATCHPOLE, B. (2003) Anti-insulin antibodies in dogs with naturally occurring diabetes mellitus. Vet Immunol Immunopathol 91, 53-60. PubMed ID 12507850
CATCHPOLE, B., GOULD, S. M., KELLETT-GREGORY, L. M. & DOBSON, J. M. (2003) Development of a multiple-marker polymerase chain reaction assay for detection of metastatic melanoma in lymph node aspirates of dogs. Am J Vet Res 64, 544-549. PubMed ID 12755292
VECCHIONE, A., CATCHPOLE, B., D'MELLO, F., KANELLOS, T. & HAMBLIN, A. (2002) Modulating immune responses with dendritic cells: an attainable goal in veterinary medicine? Vet Immunol Immunopathol 87, 215-221. PubMed ID 12072237
DAVISON, L. J., PODD, S. L., RISTIC, J. M., HERRTAGE, M. E., PARNHAM, A. & CATCHPOLE, B. (2002) Evaluation of two point-of-care analysers for measurement of fructosamine or haemoglobin A1c in dogs. J Small Anim Pract 43, 526-532. PubMed ID 12489740
CATCHPOLE, B., WARD, F. J., HAMBLIN, A. S. & STAINES, N. A. (2002) Autoreactivity in collagen-induced arthritis of rats: a potential role for T cell responses to self MHC peptides. J Autoimmun 18, 271-280. PubMed ID 12144808
CATCHPOLE, B., STELL, A. J. & DOBSON, J. M. (2002) Generation of blood-derived dendritic cells in dogs with oral malignant melanoma. J Comp Pathol 126, 238-241. PubMed ID 11945016
CATCHPOLE, B., HAMBLIN, A. S. & STAINES, N. A. (2002) Autologous mixed lymphocyte responses in experimentally-induced arthritis of the Lewis rat. Autoimmunity 35, 111-117. PubMed ID 12071434
CATCHPOLE, B., GOULD, S. M., KELLETT-GREGORY, L. M. & DOBSON, J. M. (2002) Immunosuppressive cytokines in the regional lymph node of a dog suffering from oral malignant melanoma. J Small Anim Pract 43, 464-467. PubMed ID 12400646
CATCHPOLE, B., STAINES, N. A. & HAMBLIN, A. S. (2001) Antigen presentation of Type II collagen in rats. Clin Exp Immunol 125, 478-484. PubMed ID 11531957
CATCHPOLE, B., HAMBLIN, A. S. & STAINES, N. A. (2001) T cell lines generated with type II collagen proliferate in an autologous mixed lymphocyte response. J Autoimmun 17, 181-189. PubMed ID 11712855
Brian teaches the core immunology component on the undergraduate BVetMed course as well as contributing to immunology teaching on the BSc Bioveterinary Sciences and BSc Veterinary Pathology courses. He is also the departmental contact for endocrinology in the BVetMed course.
Brian is responsible for maintaining the RVC DNA archive which is a database and sample archive from the clinical caseload that comes through the clinical pathology service.
People: Brian Catchpole
At The Royal Veterinary College we have established a national canine diabetes register. This includes a database of clinical information and an archive of residual samples. This diabetic register should allow us to progress our understanding of the causes of this disease.