Department: Comparative Biomedical Sciences
Jonathan Elliott is Professor of Veterinary Clinical Pharmacology and has been an academic at the Royal Veterinary College for approaching 32 years. For 16 of these he served as Vice Principal for Research and Innovation, taking responsibility the RVC’s for research strategy and preparing three consecutive research excellence framework submissions on behalf of the RVC (RAE2008, REF2014 and REF2021). He stepped down from the VP role on 31st March 2021 after submitting REF2021 and has just returned from a 12 month sabbatical to resume his academic duties in the Department of Comparative Biomedical Sciences.
Jonathan Elliott graduated from Cambridge University Veterinary School in 1985. After graduation, he completed an Internship at Veterinary Hospital University of Pennsylvania in Philadelphia in 1986, a PhD in vascular biology and amine oxidases at the University of Cambridge in 1989 and gained his RCVS Certificate in Small Animal Cardiology in 1990.
In 1990 he was appointed to a lectureship at the Royal Veterinary College in London where he is currently Professor in Veterinary Clinical Pharmacology. He served as Vice Principal – Research and Innovation for over 16 years (2004-2021) leading the RVC’s submissions for RAE2008, REF 2014 and REF 2021. He was awarded the Pfizer Academic Award (1998) for his research contributions to the pathophysiology of laminitis and the BSAVA Amoroso award (2001), the PetPlan Scientific Award (2005), the European Society of Nephrology and Urology Award (2007) and the BSAVA Woodrow Award (2019), all for his clinical research contributions in the area of feline chronic kidney disease. He is a Diplomate of the European College of Veterinary Pharmacology and Toxicology. He is currently President of ECVPT (2018-2021) and is a member of the International Renal Interest Society. He also chairs the Petplan Charitable Trust Scientific Committee and is a panel member of the UKRI Future Leaders Fellowship scheme.
Professor Elliott is currently a member of:
Professor Elliott is a past member of The Veterinary Products Committee and BBSRCs Training Awards Committee
Jonathan's research interests encompass the pathophysiology of renal, cardiac and vascular diseases of companion animals. He belongs to the Comparative Physiology & Clinical Sciences research programme.
Orcid ID: http://orcid.org/0000-0002-4517-6590
Finding, Elizabeth J. T.; Elliott, Jonathan; Harris, Patricia A.; Menzies-Gow, Nicola J.
Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies
Research In Veterinary Science (2022)
Elliott, J; Geddes RF
New concepts in phosphorus homeostastis and its impact on renal health with particular reference to the cat
The Veterinary Journal (2022).
Tang, P-K; Geddes, RF; Jepson, RE; Elliott, J
A feline-focused review of chronic kidney disease-mineral and bone disorders – Part 1: Physiology of calcium handling
The Veterinary Journal, 275: 105719: July 2021
Geddes RF, van den Broek DHN, Chang YM, Biourge V, Elliott J, Jepson RE.
The effect of attenuating dietary phosphate restriction on blood ionized calcium concentrations in cats with chronic kidney disease and ionized hypercalcemia.
J Vet Intern Med. 2021 Mar;35(2):997-1007.
Wilshaw J, Stein M, Lotter N, Elliott J, Boswood A
The effect of myxomatous mitral valve disease severity on packed cell volume in dogs.
J Small Anim Pract. 2021 Jun;62(6):428-436.
Foth S, Meller S, Kenward H, Elliott J, Pelligand L, Volk HA.
The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome.
BMC Vet Res. 2021 Jun 21;17(1):222.
Wilshaw J, Rosenthal SL, Wess G, Dickson D, Bevilacqua L, Dutton E, Deinert M, Abrantes R, Schneider I, Oyama MA, Gordon SG, Elliott J, Xia D, Boswood A.
Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease.
J Vet Intern Med. 2021 Mar;35(2):755-770.
Coltherd JC, Alexander JE, Pink C, Rawlings J, Elliott J, Haydock R, Carvell-Miller LJ, Biourge VC, Molina L, Butterwick R, Logan DW, Watson P, Bakke AM
Towards establishing no observed adverse effect levels (NOAEL) for different sources of dietary phosphorus in feline adult diets: results from a 7-month feeding study.
Br J Nutr. 2021 Feb 8:1-16.
Enache AE, Dietrich UM, Drury O, Trucco E, MacGillivray T, Syme H, Elliott J, Chang YM.
Changes in retinal vascular diameters in senior and geriatric cats in association with variation in systemic blood pressure.
J Feline Med Surg. 2021 Mar 19:1098612X21997629.
Tang PK, Geddes RF, Chang YM, Jepson RE, Bijsmans E, Elliott J.
Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease.
J Vet Intern Med. 2021 Jan;35(1):321-332.
Lawson JS, Syme HM, Wheeler-Jones CPD, Elliott J.
Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease. Vet J. 2021 Jan;267:105582. doi: 10.1016/j.tvjl.2020.105582. (2021)
Sargent HJ, Elliott J, Jepson RE.
The new age of renal biomarkers: does SDMA solve all of our problems? J Small Anim Pract. 2021 Feb;62(2):71-81. doi: 10.1111/jsap.13236
Biourge V, Delmotte S, Feugier A, Bradley R, McAllister M, Elliott J
An artificial neural network-based model to predict chronic kidney disease in aged cats.
J Vet Intern Med. 2020 Sep 7;34(5):1920-31
Pelligand L, Guillot E, Geneteau A, Guyonnet J, Magnier R, Elliott J, Peyrou M, Jacobs M.
Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs. Front Vet Sci. 2020 Apr 28;7:151. doi: 10.3389/fvets.2020.00151. eCollection 2020.
McKenna, M; Pelligand, L; Elliott, J; Cotter, D; Jepson, R
Relationship between serum iohexol clearance, serum SDMA concentration, and serum creatinine concentration in non-azotemic dogs.
Journal of Veterinary Internal Medicine. 2019.
McKenna, M; Pelligand, L; Elliott, J; Walker, D; Jepson, R
Clinical utility of estimation of glomerular filtration rate in dogs
Journal of Veterinary Internal Medicine. 2019
Lawson, J S; Syme, H M; Wheeler-Jones, C P D; Elliott, J.
Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype.
RESEARCH IN VETERINARY SCIENCE, 12799-102. 2019
Bradley, R; Tagkopoulos, I; Kim, M; Kokkinos, Y; Panagiotakos, T; Kennedy, J; De Meyer, G; Watson, P; Elliott, J.
Predicting early risk of chronic kidney disease in cats using routine clinical laboratory tests and machine learning.
Journal of Veterinary Internal Medicine, 2019
Sargent, H J; Jepson, R E; Chang, Y-M; Biourge, V C; Bijsmans, E S; Elliott, J.
Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.
Journal of Veterinary Internal Medicine, 2019
Suokko, M; Saloranta, L; Lamminen, T; Laine, T; Elliott, J.
Ropinirole eye drops induce vomiting effectively in dogs: a randomised, double-blind, placebo-controlled clinical study.
VETERINARY RECORD, 2019
Al-Agele, R; Paul, E; Taylor, S; Watson, C; Sturrock, C; Drakopoulos, M; Atwood, R C; Rutland, C S; Menzies-Gow, N J; Knowles, E; Elliott, J; Harris, P; Rauch, C.
Physics of Animal Health: On the mechano-biology of hoof growth and form.
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2019
Conroy, M C; Brodbelt, D C; O'Neill, D G; Chang, Y M; Elliott, J.
Chronic kidney disease in cats attending primary care practice in the UK: a VetCompass study.
VETERINARY RECORD, 2019
Covey, H L; Chang, Y M; Elliott, J; Syme, H M.
Changes in thyroid and renal function after bilateral thyroidectomy in cats.
Journal of Veterinary Internal Medicine, 2019
Pelander, L; Häggström, J; Larsson, A; Syme, H M; Elliott, J; Heiene, R; Ljungvall, I.
Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs.
Journal of Veterinary Internal Medicine, 2019
Glaus, T M; Elliott, J; Herberich, E; Zimmering, T; Albrecht, B.
Efficacy of long-term oral telmisartan treatment in cats with hypertension: Results of a prospective European clinical trial.
Journal of Veterinary Internal Medicine, 33;2:413-422. 2019
Pelander, L; Brunchault, V; Buffin-Meyer, B; Klein, J; Breuil, B; Zürbig, P; Magalhães, P; Mullen, W; Elliott, J; Syme, H; Schanstra, J P; Häggström, J; Ljungvall, I.
Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs.
VETERINARY JOURNAL, 24973-79. 2019
Alexander, J; Stockman, J; Atwal, J; Butterwick, R; Colyer, A; Elliott, D; Gilham, M; Morris, P; Staunton, R; Renfrew, H; Elliott, J; Watson, P.
Effects of the long-term feeding of diets enriched with inorganic phosphorus on the adult feline kidney and phosphorus metabolism.
BRITISH JOURNAL OF NUTRITION, 211-21, 2018
Finch, N; Syme, H M; Elliott, J.
Development of an estimated glomerular filtration rate formula in cats.
Journal of Veterinary Internal Medicine, 2018
Conroy, M; Chang, Y-M; Brodbelt, D; Elliott, J.
Survival after diagnosis of hypertension in cats attending primary care practice in the UK.
Journal of Veterinary Internal Medicine, 1-10. 2018
Timpson, A; De Mestre, A M; Elliott, J; Harris, P A; Cheng, Z; Mirczuk, S M; Callan, L; Rainbow, L; Menzies-Gow, N J.
Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.
Journal of Equine Veterinary Science, 2018
Finding, E J T; Lawson, C; Elliott, J; Harris, P A; Menzies-Gow, N J.
Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,.
Geddes, R F; Jepson, R E; Forcada, Y; Elliott, J; Syme, H M.
Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats.
VETERINARY JOURNAL, 23534-41. (2018)
Van Den Broek, D H N; Chang, Y-M; Elliott, J; Jepson, R E.
Prognostic importance of plasma total magnesium in a cohort of cats with azotemic chronic kidney disease
JOURNAL OF VETERINARY INTERNAL MEDICINE, (2018)
Van Den Broek, D H N; Geddes, R F; Williams, T L; Chang, Y-M; Elliott, J; Jepson, R E.
Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 32;2:727-735. (2018)
Lawson, J S; Syme, H M; Wheeler-Jones, C P D; Elliott, J.
Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1.
BMC Veterinary Research, 14; 76. (2018)
Lawson, J S; Liu, H-H; Syme, H M; Purcell, R; Wheeler-Jones, C P D; Elliott, J.
The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-β1.
PLoS One, 13;8:e0202577. 2018
Knowles, E J; Moreton-Clack, M C; Shaw, S; Harris, P A; Elliott, J; Menzies-Gow, N J.
Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross reactivity or interference.
EQUINE VETERINARY JOURNAL, (2017)
Knowles, E J; Harris, P A; Elliott, J; Menzies-Gow, N J.
Use of the oral sugar test in ponies when performed with or without prior fasting.
EQUINE VETERINARY JOURNAL, 49;4:519-524. (2017)
Hezzell, M J; Boswood, A; Lopez-Alvarez, J; Lotter, N S; Elliott, J.
Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study.
Journal of Veterinary Cardiology, 19;4:325-328. (2017)
Menzies-Gow NJ, Harris PA, Elliott J.
Prospective cohort study evaluating risk factors for the development of pasture-associated laminitis in the United Kingdom.
Equine Vet J. 2017 May;49(3):300-306.
Kenward, H; Elliott, J; Lee, T; Pelligand, L.
Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study.
BMC Veterinary Research, 13;1:244. (2017)
Williams, T L; Elliott, J; Syme, H M; Archer, J.
Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats.
RESEARCH IN VETERINARY SCIENCE, 115; 412-417. (2017)
Crossley, V J; Debnath, A; Chang, Y M; Fowkes, R; Elliott, J; Syme, H.
Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 31; 4; 1028-1034; (2017)
Van Den Broek, H; Chang, Y M; Elliott, J; Jepson, R E.
Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia.
JOURNAL OF VETERINARY INTERNAL MEDICINE (2017)
Bijsmans, E S; Doig, M; Jepson, R E; Syme, H M; Elliott, J; Pelligand, L.
Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE, (2016).
Brown, C; Elliott, J; Schmiedt, C; Brown, S.
Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses.
VETERINARY PATHOLOGY, 2016. 53;2:309-326.
Jepson RE, Warren HR, Syme HM, Elliott J, Munroe PB. Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study. J Small Anim Pract. 2016 Nov;57(11):580-588.
Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635.
Cowgill LD, Polzin DJ, Elliott J, Nabity MB, Segev G, Grauer GF, Brown S, Langston C, van Dongen AM. Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury? Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):995-1013.
Vaden SL, Elliott J. Management of Proteinuria in Dogs and Cats with Chronic Kidney Disease. Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):1115-30.
Sanchez-Lara, AC; Elliott, J; Syme, HM; Brown, CA; Haylor, JL. Feline Chronic Kidney Disease Is Associated with Upregulation of Transglutaminase 2: A Collagen Cross-Linking Enzyme.
VETERINARY PATHOLOGY, 2015, 52;3:513-523. http://dx.doi.org/10.1177/0300985814542811
Lawson J, Elliott J, Wheeler-Jones C, Syme H, Jepson R. Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury. Vet J. 2015 Jan;203(1):18-26. http://dx.doi.org/10.1016/j.tvjl.2014.10.009
Kenward H, Pelligand L, Savary-Bataille K, Elliott J. Nausea: current knowledge of mechanisms, measurement and clinical impact. Vet J. 2015 Jan;203(1):36-43. http://dx.doi.org/10.1016/j.tvjl.2014.10.007
Lees P, Pelligand L, Elliott J, Toutain PL, Michels G, Stegemann M. Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review. J Vet Pharmacol Ther. 2015 Feb;38(1):1-14. http://dx.doi.org/10.1111/jvp.12185
Finch NC, Heiene R, Elliott J, Syme HM, Peters AM. Determination of extracellular fluid volume in healthy and azotemic cats. J Vet Intern Med. 2015 Jan;29(1):35-42. http://dx.doi.org/10.1111/jvim.12506
Bijsmans, E S; Jepson, R E; Chang, Y M; Syme, H M; Elliott, J.
Changes in systolic blood pressure over time in healthy cats and cats with chronic kidney disease.
Journal of Veterinary Internal Medicine, 29;3:855-61. (2015).
Chetboul, V; Reynolds, BS; Trehiou-Sechi, E; Nguyen, P; Concordet, D; Sampedrano, CC; Testault, I; Elliott, J; Abadie, J; Biourge, V; Lefebvre, HP. (2014)
Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study.
PLoS One, 9;6:e97862. http://dx.doi.org/10.1371/journal.pone.0097862
Lopez-Alvarez, J; Boswood, A; Moonarmart, W; Hezzell, M J; Lotter, N; Elliott, J. (2014)
Longitudinal Electrocardiographic Evaluation of Dogs with Degenerative Mitral Valve Disease.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28;2:393-400.
Kenward, H; Pelligand, L; Elliott, J. (2014)
Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.
EXPERIMENTAL BRAIN RESEARCH
http://dx.doi.org/10.1007/s00221-014-3961-6 [Epub ahead of print]
Menzies-Gow, N J; Wray, H; Bailey, S R; Harris, P A; Elliott, J. (2014)
The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies.
EQUINE VETERINARY JOURNAL, 46;3:317-321.
Jepson RE, Syme HM, Elliott J. (2014)
Plasma renin activity and aldosterone concentrations in hypertensive cats with and without azotemia and in response to treatment with amlodipine besylate.
JOURNAL OF VETERINARY INTERNAL MEDICINE. 2014 Jan-Feb;28(1):144-53.
Braff, J; Obare, E; Yerramilli, M; Elliott, J; Yerramilli, M.
Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats.
Journal of Veterinary Internal Medicine, 28;6:1699-1701. (2014)
Williams, TL; Elliott, J; Syme, HM. (2013)
Renin-Angiotensin-Aldosterone System Activity in Hyperthyroid Cats with and without Concurrent Hypertension..
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27;3:522-529.
Reynolds, B S; Chetboul, V; Nguyen, P; Testault, I; Concordet, D V; Sampedrano, C C; Elliott, J; Trehiou-Sechi, E; Abadie, J; Biourge, V; Lefebvre, H P. (2013)
Effects of Dietary Salt Intake on Renal Function: A 2-Year Study in Healthy Aged Cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27;3:507-515.
Finch, N C; Geddes, R F; Syme, H M; Elliott, J.
Fibroblast Growth Factor 23 (FGF-23) Concentrations in Cats with Early Nonazotemic Chronic Kidney Disease (CKD) and in Healthy Geriatric Cats.
Journal of Veterinary Internal Medicine, 27;2:227-33. (2013)
O'Neill, DG; Elliott, J; Church, DB; McGreevy, PD; Thomson, PC; Brodbelt, DC (2013)
Chronic Kidney Disease in Dogs in UK Veterinary Practices: Prevalence, Risk Factors, and Survival
JOURNAL OF VETERINARY INTERNAL MEDICINE. http://dx.doi.org/10.1111/jvim.12090
Finch N. C.; Syme H. M.; Elliott J. (2012)
Association of urinary cadmium excretion with feline hypertension
VETERINARY RECORD 170 (5), 125-U47 DOI: 10.1136/vr.100264
Pelligand L.; King J. N.; Toutain P. L.; Elliott, J; Lees, P (2012)
Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 35 (1): 19-32
Finch, NC; Syme, HM; Elliott, J; Peters, AM; Gerritsen, R; Croubels, S; Heine, R (2012)
Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats
Source: AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (12): 1652-1659
Wakeling, J; Elliott, J; Syme, H (2011)
Evaluation of Predictors for the Diagnosis of Hyperthyroidism in Cats
JOURNAL OF VETERINARY INTERNAL MEDICINE 25(5): 1057-1065
Jones, ID; Fuentes, VL; Wrigglesworth, D; Mort, E; Elliott, J (2011)
Comparison of flow-mediated vasodilation in femoral and brachial arteries in healthy dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH 72(8): 1029-1037
Pelligand, L; Lees, P; Elliott, J (2011)
Development and validation of a timed urinary collection system for use in the cat
LABORATORY ANIMALS 45 (3): 196-203 DOI: 10.1258/la.2011.
Katz, LM: Marr, CM; Elliott, J (2011)
Characterization of the responses of equine digital veins and arteries to calcitonin gene-related peptide
AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (7): 975-981
BROOKS, A.C.; MENZIES-GOW, N.J.; WHEELER-JONES, C.P.D.; BAILEY, S.R.; ELLIOTT, J.; CUNNINGHAM, F.M. (2009) Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. J vet Pharmacol Therap 32, 189-196. PubMed ID: 19290950
JEPSON, R E; BRODBELT, D C; VALLANCE, C; SYME, H E; ELLIOTT, J
Evaluation of Predictors of the Development of Azotemia in Cats.
Journal of Veterinary Internal Medicine, 23;4:806-813.
WAKELING, J., MOORE, K., ELLIOTT, J. & SYME, H. (2008) Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. J Small Anim Pract 49, 287-294. PubMed ID 18422499
MENZIES-GOW, N. J., SEPULVEDA, M. F., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2008) Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. Am J Vet Res 69, 199-207. PubMed ID 18241016
MENZIES-GOW, N. J., BAILEY, S. R., BERHANE, Y., BROOKS, A. C. & ELLIOTT, J. (2008) Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin. Am J Vet Res 69, 349-355. PubMed ID 18312133
BERHANE, Y., BAILEY, S. R., PUTIGNANO, C. & ELLIOTT, J. (2008) Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit. J Vet Pharmacol Ther 31, 1-8. PubMed ID 18177312
BAILEY, S. R., HABERSHON-BUTCHER, J. L., RANSOM, K. J., ELLIOTT, J. & MENZIES-GOW, N. J. (2008) Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am J Vet Res 69, 122-129. PubMed ID 18167097
JEPSON, R E; SYME, H M; VALLANCE, C; ELLIOTT, J
Plasma asymmetric dimethylarginine, symmetric dimethylarginine, L-arginine, and nitrite/nitrate concentrations in cats with chronic kidney disease and hypertension.
Journal of Veterinary Internal Medicine, 22;2:317-324. (2008)
ZERPA, H., BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2007) Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase. Eur J Pharmacol 569, 212-221. PubMed ID 17560569
SYME, H. M., FLETCHER, M. G., BAILEY, S. R. & ELLIOTT, J. (2007) Measurement of aldosterone in feline, canine and human urine. J Small Anim Pract 48, 202-208. PubMed ID 17381765
BROOKS, A. C., MENZIES-GOW, N. J., WHEELER-JONES, C., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2007) Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production. Inflamm Res 56, 154-161. PubMed ID 17522813
BAILEY, S. R., MENZIES-GOW, N. J., HARRIS, P. A., HABERSHON-BUTCHER, J. L., CRAWFORD, C., BERHANE, Y., BOSTON, R. C. & ELLIOTT, J. (2007) Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis. J Am Vet Med Assoc 231, 1365-1373. PubMed ID 17975996
BAILEY, S. R. & ELLIOTT, J. (2007) The corticosteroid laminitis story: 2. Science of if, when and how. Equine Vet J 39, 7-11. PubMed ID 17228587
ZERPA, H., BAILEY, S. R., BERHANE, Y. & ELLIOTT, J. (2006) Pharmacological characterization of alpha1-adrenoceptors in equine digital veins. J Vet Pharmacol Ther 29, 55-61. PubMed ID 16420303
SYME, H. M., MARKWELL, P. J., PFEIFFER, D. & ELLIOTT, J. (2006) Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. J Vet Intern Med 20, 528-535. PubMed ID 16734085
ELLIOTT, J. & SYME, H. M. (2006) Proteinuria in chronic kidney disease in cats--prognostic marker or therapeutic target? J Vet Intern Med 20, 1052-1053. PubMed ID 17063695
ELLIOTT, J. & BAILEY, S. R. (2006) Gastrointestinal derived factors are potential triggers for the development of acute equine laminitis. J Nutr 136, 2103S-2107S. PubMed ID 16772511
BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2006) Assessment of endothelium-dependent vasodilation in equine digital resistance vessels. J Vet Pharmacol Ther 29, 387-395. PubMed ID 16958783
MENZIES-GOW, N. J., BAILEY, S. R., STEVENS, K., KATZ, L., ELLIOTT, J. & MARR, C. M. (2005) Digital blood flow and plasma endothelin concentration in clinically endotoxemic horses. Am J Vet Res 66, 630-636. PubMed ID 15900943
BOTHAM, K. M., BRAVO, E., ELLIOTT, J. & WHEELER-JONES, C. P. (2005) Direct interaction of dietary lipids carried in chylomicron remnants with cells of the artery wall: implications for atherosclerosis development. Curr Pharm Des 11, 3681-3695. P
Jonathan teaches renal physiology (BSc year 1) and aspects of pharmacology (BVetMed years 2, 3, 4 and 5; BSc year 2). He is a tutor to BVetMed students in years 1 and 2.
Vet Compass Project Type: Cat
This project, funded by Ceva, estimated the
prevalence of,and risk-factorsfor chronic kidney disease in cats attending VetCompass-participating veterinary practices in the United Kingdom. As a second objective, the prevalence of hypertension ancurrent practices for measuring and treating hypertension were explored.
Kidneys filter the blood and produce urine and so problems with kidney function can result in a variety of health problems for a cat. Chronic kidney disease (CKD) is the persistent loss of kidney function over a period of time. CKD is the most common kidney disease affecting cats as they get older. The RVC’s Geriatric Cat Clinic was established in 1992 with the aim of researching the common conditions of older cats and to help with the care and medical management of the cats that attend the clinic.
A four year study of laminitis in ponies, measuring physical, metabolic and management data, identifying significant factors associated with laminitis such as basal serum insulin concentration, insulin concentration in response to the OST, basal plasma adiponectin concentration and the presence of divergent hoof growth rings on the feet, and making recommendations for treatment based on this.