Department: Comparative Biomedical Sciences

Campus: Hawkshead

Research Groups: Safe and Sustainable Food

Ali is a member of the Reproduction Research Group. His research is based on oocyte biology and embryology of domesticated and farm animal species and uterine embryo interaction and mechanism of embryo implantation.

Ali trained as a Veterinarian in Tehran University and served for about 7 years as a Lecturer in Animal Reproduction before moving to the United Kingdom for further education. He gained his MSc in 1995 and PhD in 1999 from the University of Edinburgh in Scotland.

Ali undertook at PhD at the Roslin Institute where he worked alongside Professor Keith Campbell, creator of Dolly the cloned sheep from differentiated cells. Following this he moved on to undertake post-doctoral work at the University of Manchester, investigating the role of Leukaemia Inhibitory Factor with Sue Kimber. Subsequently he joined Nottingham University as a Research Fellow working with Professor Bob Webb to investigate the effects of diet on oocyte & embryo quality in lactating dairy cows.

In June 2006, Ali accepted a Lectureship position at the Royal Veterinary College (Department of Veterinary Basic Sciences). His research in the area of female reproduction continues. He was promoted to Senior Lecturer position in 2012 and then to Reader position in September 2016.

During his time at the Roslin Institute Ali's studies established that improvement in cytoplasmic maturation of bovine oocytes improves the rate of blastocyst development (Fouladi-Nashta et al., 1998, Biology of Reproduction 59: 255-262).

At the University of Manchester Ali investigated the role of leukaemia inhibitory factor (LIF) on implantation of embryos in mice. Using LIF gene knocked-out mice he showed misregulation of signalling mechanisms and absence of changes in the uterine endometrium associated uterine receptivity (Fouladi-Nashta et al., 2005, Developmental Biology, 281:1-21) resulting in infertility. They also demonstrated that LIF inhibitor can effectively inhibit its effects on decidualisation of uterine stroma cells (Fouladi-Nashta et al., 2004, Journal of Endocrinology, 181: 477-492).

Whilst at Nottingham University Ali investigated the effects of diet on oocyte and embryo quality in lactating dairy cows. Diets can modify the profiles of hormones and local production of growth factors thereby influencing reproductive function (Fouladi-Nashta et al., 2007, Biology of Reproduction 77: 9-17). He developed diets which can promote reproductive cyclicity and also increase pregnancy rate in post-calving dairy cows (Garnsworthy et al., 2008). He also developed a simple and fast but reliable technique for assessment of blastocysts (Reproductive BioMedicine Online, 2005, 10: 497-502).

Hanousek K, Salavati M, Fouladi-Nashta A. (2018) Effect of horse gender on British Eventing competition performance: an observational study between 1998 and 2016. Vet Rec. 2018 Mar 23. pii: vetrec-2017-104719. doi: 10.1136/vr.104719

Tremaine TD, Fouladi-Nashta AA. (2018) Immunolocalization of angiogenic growth factors in the ovine uterus during the oestrus cycle and in response to Steroids. Reprod Domest Anim. 2018 Mar 5. doi: 10.1111/rda.13156.

Soto-Heras S, Roura M, Catalá MG, Menéndez-Blanco I, Izquierdo D, Fouladi-Nashta AA, Paramio MT. (2018) Differential proteomic profiling of endometrium and plasma indicate the importance of hydrolysis in bovine endometritis. J Dairy Sci. 100:9324-9337.

Husna AU, Azam A, Qadeer S, Awan MA, Nasreen S, Shahzad Q, Fouladi-Nashta A, Khalid M, Akhter S. (2017) Sperm preparation through Sephadex™ filtration improves in vitro fertilization rate of buffalo oocytes. Reprod Domest Anim. 2018 Apr;53(2):377-384. doi: 10.1111/rda.13117. Epub 2017 Dec 14.

Goodarzi A, Zare Shahneh A, Kohram H, Sadeghi M, Moazenizadeh MH, Fouladi-Nashta A, Dadashpour Davachi N. Effect of melatonin supplementation in the long-term preservation of the sheep ovaries at different temperatures and subsequent in vitro embryo production. Theriogenology. 2018 Jan 15;106:265-270. doi: 10.1016/j.theriogenology.2017.10.009.

Zhang SD, Dong SW, Wang DS, Oguejiofor CF, Fouladi-Nashta AA, Yang ZQ, Yan ZT. (2017) Differential proteomic profiling of endometrium and plasma indicate the importance of hydrolysis in bovine endometritis. J Dairy Sci. 2017 Nov;100(11):9324-9337. doi: 10.3168/jds.2016-12365. Epub 2017 Sep 13.

Roura M, Catalá MG, Soto-Heras S, Hammami S, Izquierdo D, Fouladi-Nashta A, Paramio MT. (2017) Linoleic (LA) and linolenic (ALA) acid concentrations in follicular fluid of prepubertal goats and their effect on oocyte in vitro maturation and embryo development. Reprod Fertil Dev. doi: 10.1071/RD17174. [Epub ahead of print]

Soto-Heras S, Roura M, Catalá MG, Menéndez-Blanco I, Izquierdo D, Fouladi-Nashta AA, Paramio MT (2017) Beneficial effects of melatonin on in vitro embryo production from juvenile goat oocytes. Reprod Fertil Dev. 2017 Jun 19. doi: 10.1071/RD17170. [Epub ahead of print]

Fouladi-Nashta AA, Raheem KA, Marei WF, Ghafari F, Hartshorne GM (2016). Regulation and roles of hyaluronan system in mammalian reproduction. Reproduction 153 (2):R43-R58.

Marei WFA, Wathes DC, Raheem KA, Mohey-Elsaeed O, Ghafari F, Fouladi-Nashta AA (2016). Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep. Reprod Fertil Dev. 2017 Sep;29(9):1763-1773. doi: 10.1071/RD16232.

Marei WF, Tremaine T, Salavati M, Khalid, M and Fouladi-Nashta AA. (2016) Hyaluronan or its eraser hyaluronidase, which one is better for embryo development? Theriogenology. 2016 Sep 1;86(4):940-948.

Raheem KA, Marei WFA, Campbell BK, Fouladi-Nashta AA. (2016) In vivo and in vitro studies of MUC1 regulation in sheep endometrium. Theriogenology 85:1635-1643.

Yousefi AR, Kohram H, Zare Shahneh A, Zamiri MJ, Fouladi-Nashta AA. (2016) Effects of dietary supplementation of pioglitazone on metabolism, milk yield, and reproductive performance in transition dairy cows. Theriogenology. 2016 Jan 19. doi:10.1016/j.theriogenology.2016.01.015.

Oguejiofor CF, Cheng Z, Abudureyimu A, Fouladi-Nashta AA, Wathes DC. (2015) Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity. Biol Reprod. 93(4):100. doi: 10.1095/biolreprod.115.128868. Epub 2015 Sep 9.

Oguejiofor CF, Cheng Z, Abudureyimu A, Anstaett OL, Brownlie J, Fouladi-Nashta AA, Wathes DC. (2015) Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide. Biol Reprod. 93(4):101. doi: 10.1095/biolreprod.115.128876. Epub 2015 Sep 9.

Mohey-Elsaeed O, Marei WF, Fouladi-Nashta AA, El-Saba AA. (2015) Histochemical structure and immunolocalisation of the hyaluronan system in the dromedary oviduct. Reprod Fertil Dev. doi: 10.1071/RD14187. [Epub ahead of print]

Chavoshinejad R, Marei WF, Hartshorne GM, Fouladi-Nashta AA. (2014) Localisation and endocrine control of hyaluronan synthase (HAS) 2, HAS3 and CD44 expression in sheep granulosa cells. Reprod Fertil Dev. doi: 10.1071/RD14294. [Epub ahead of print]

Ghaffarilaleh V, Fouladi-Nashta A, Paramio MT. (2014) Effect of α-linolenic acid on oocyte maturation and embryo development of prepubertal sheep oocytes. Theriogenology. 82:686-96.

Marei WF, Abayasekara DR, Wathes DC, Fouladi-Nashta AA.( 2014) Role of PTGS2-generated PGE2 during gonadotrophin-induced bovine oocyte maturation and cumulus cell expansion. Reprod Biomed Online. 28:388-400.

Raheem KA and Fouladi-Nashta AA. (2014) Isolation and characterization of endometrial luminal epithelial and stromal cells in vitro.  Sokoto J Vet Sci, 12:1-8.

Salavati M, Ghafari F, Zhang T, Fouladi-Nashta AA. (2013) Influence of caffeine pretreatment on biphasic in vitro maturation of dog oocytes. Theriogenology 80:784-92.

 Wathes DC, Cheng Z, Marei WF, and Fouladi-Nashta AA (2013) Polyunsaturated fatty acids and fertility in female mammals: an update. CAB reviews 2013 8, N0. 041. doi: 10.1079/PAVSNNR20138041

Raheem KA, Marei WF, Mifsud K, Khalid M, Wathes DC, Fouladi-Nashta AA. (2013) Regulation of the hyaluronan system in ovine endometrium by ovarian steroids. Reproduction. 145:491-504.

Marei WF, Salavati M, Fouladi-Nashta AA (2013) Critical role of hyaluronidase-2 during preimplantation embryo development. Mol Hum Reprod. 19:590-9.

Swangchan-Uthai T, Chen Q, Kirton SE, Fenwick MA, Cheng Z, Patton J, Fouladi-Nashta AA, Wathes DC. (2013) Influence of energy balance on the antimicrobial peptides S100A8 and S100A9 in the endometrium of the post-partum dairy cow. Reproduction 145:527-39.

Swangchan-Uthai T., Lavender C.R., Cheng Z., Fouladi-Nashta A.A., Wathes D.C. (2012) Time Course of Defense Mechanisms in Bovine Endometrium in Response to Lipopolysaccharide. Biol Reprod. 87:135, 1–13

Dirandeh E, Towhidi A, Zeinoaldini S, Ganjkhanlou M, Ansari Pirsaraei Z, Fouladi-Nashta A. (2013) Effects of different polyunsaturated fatty acid supplementations during the postpartum periods of early lactating dairy cows on milk yield, metabolic responses, and reproductive performances. J Anim Sci. 91:713-21.

Salavati M., Ghafari F., Zhang T., Fouladi-Nashta A.A. (2012) Effects of oxygen concentration on in vitro maturation of canine oocytes in a chemically defined serum free media. Reproduction 144: 547-56.

Marei W.F., Ghafari F., Fouladi-Nashta A.A. (2012) Role of hyaluronic acid in maturation and further early embryo development of bovine oocytes. Theriogenology 78: 670-7.

Marei W.F., Wathes D.C., Fouladi-Nashta A.A. (2012) Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes, Reproduction Fertility and Development  24: 679-90.

Marei WF, Wathes DC, Fouladi-Nashta AA (2011) Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. Reproduction Fertility and Development 24: 679–690.

Marei W.F., Wathes D.C., Fouladi-Nashta A.A. (2010) Impact of linoleic acid on bovine oocyte maturation and embryo development. Reproduction 139: 979-988.

MAREI, W.F., WATHES, D.C. & FOULADI-NASHT, A.A. (2009) The effect of linolenic Acid on bovine oocyte maturation and development. Reproduction. 138: 771-81. PubMed ID: 19633135

FOULADI-NASHTA, A.A.,WONNACOTT, K.E., GUTIERREZ, C.G, GONG, J.G., SINCLAIR, K.D., GARNSWORTH, P.C. & WEBB, R. (2009) Oocyte quality in lactating dairy cows fed on high levels of n-3 and n-6 fatty acids. Reproduction 138, 771-81. PubMed ID: 19633135

GARNSWORTH, P.C., FOULADI-NASHT, A.A., MANN, GE., SINCLAIR, K.D. & WEBB, R. (2009) Effect of dietary-induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows. Reproduction.  137, 759-68. PubMed ID: 19129370

FOULADI-NASHTA, A. A., MOHAMET, L., HEATH, J. K. & KIMBER, S. J. (2008) Interleukin 1 signaling is regulated by leukemia inhibitory factor (LIF) and is aberrant in Lif-/- mouse uterus. Biol Reprod 79, 142-153. PubMed ID 18337516

FOULADI-NASHTA, A. A., GUTIERREZ, C. G., GONG, J. G., GARNSWORTHY, P. C. & WEBB, R. (2007) Impact of dietary fatty acids on oocyte quality and development in lactating dairy cows. Biol Reprod 77, 9-17. PubMed ID 17344470

SINGH, R., FOULADI-NASHTA, A. A., LI, D., HALLIDAY, N., BARRETT, D. A. & SINCLAIR, K. D. (2006) Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem 99, 146-155. PubMed ID 16598758

FOULADI-NASHTA, A. A. & CAMPBELL, K. H. (2006) Dissociation of oocyte nuclear and cytoplasmic maturation by the addition of insulin in cultured bovine antral follicles. Reproduction 131, 449-460. PubMed ID 16514188

NICHOLAS, B., ALBERIO, R., FOULADI-NASHTA, A. A. & WEBB, R. (2005) Relationship between low-molecular-weight insulin-like growth factor-binding proteins, caspase-3 activity, and oocyte quality. Biol Reprod 72, 796-804. PubMed ID 15564596

FOULADI-NASHTA, A. A., JONES, C. J., NIJJAR, N., MOHAMET, L., SMITH, A., CHAMBERS, I. & KIMBER, S. J. (2005) Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Dev Biol 281, 1-21. PubMed ID 15848385

FOULADI-NASHTA, A. A., ALBERIO, R., KAFI, M., NICHOLAS, B., CAMPBELL, K. H. & WEBB, R. (2005) Differential staining combined with TUNEL labelling to detect apoptosis in preimplantation bovine embryos. Reprod Biomed Online 10, 497-502. PubMed ID 15901458

FOULADI NASHTA, A. A., ANDREU, C. V., NIJJAR, N., HEATH, J. K. & KIMBER, S. J. (2004) Role of leukemia inhibitor factor (LIF) in decidualisation of murine uterine stromal cells in vitro. J Endocrinol 181, 477-492. PubMed ID 15171696

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