Department: Pathobiology and Population Sciences

Campus: Hawkshead

Research Groups: Host-Pathogen Interactions and Vaccinology, Immune Regulation and Cancer

Jonathan is a Lecturer in Veterinary Anatomic Pathology at the Royal Veterinary College. He is a Diplomate of the European College of Veterinary Pathologists (ECVP) and a Royal College of Veterinary Surgeons (RCVS) Recognised Specialist in Veterinary Pathology. He has also completed the Postgraduate Certificate in Veterinary Education and is a Fellow of the Higher Education Academy (FHEA).

Jonathan graduated from Bristol Vet School in 2005. He spent a brief time in mixed practice and then started a residency in veterinary pathology in 2006 at Liverpool Vet School. He became a Diplomate of the European College of Veterinary Pathologists in 2010 and a clinician teacher at Leahurst Surveillance Centre. He completed his PhD investigating Pathological Epithelial Cell Shedding in the Small Intestine in 2013. He then became a post-doctoral researcher investigating NF-κB signalling in IBD until he moved to the RVC as Lecturer in Veterinary Anatomic Pathology in 2015.

Jonathan’s research interests are in intestinal epithelial signalling and cell death mechanisms in the context of gut barrier dysfunction. He is particularly interested in intestinal epithilial dynamics and how intestinal bacterial populations interact with the epithelial and immune cell compartments in health and disease.

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. Michael Burkitt, Jonathan M Williams, Tristan Townsend, Rachael Hough, Carrie A Duckworth, David Mark Pritchard. Cell Death Dis. 2017 Jul 20;8(7):e2939. doi: 10.1038/cddis.2017.332.   

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models. Michael D. Burkitt, Carrie A. Duckworth, Jonathan M. Williams, D. Mark Pritchard. Disease Models & Mechanisms 2017 10: 89-104; doi: 10.1242/dmm.027649

Intestinal preparation techniques for histological analysis in the mouse. Williams, J.M., Duckworth, C.A., Vowell, K., Burkitt, M.D., and Pritchard, D.M. 2016. Curr. Protoc. Mouse Biol. 6:148-168. doi: 10.1002/cpmo.2

Bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice. Carrie Duckworth, Abdul Abuderman, Michael Burkitt, Jonathan Williams. Lorraine O'Reilly, and David Pritchard. American Journal of Physiology GI&Liver

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Dammann, Khare V, Lang, Claudel, Harpain F, Granofszky N, Evstatiev R, Williams JM, Pritchard DM, Watson A, Gasche C. Biochim Biophys Acta. 2015 May 31. pii: S0167-4889(15)00185-8. doi: 10.1016/j.bbamcr.2015.05.031. [Epub ahead of print]

Murine models of Helicobacter (pylori or felis)-associated gastric cancer. Duckworth, C.A., Burkitt, M.D., Williams, J.M., Parsons, B.N., Tang, J.M.F., and Pritchard, D.M. 2015. Curr. Protoc. Pharmacol. 69:14.34.1-14.34.35. doi: 10.1002/0471141755.ph1434s69

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. Burkitt M.D., Hanedi A., Duckworth C.A., Williams J.M., Dimaline R., Caamano J. and Pritchard, DM. Journal of Pathology. doi: 10.1002/path.4527

Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip. Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J. and Pritchard, D. M. Veterinary Pathology. Published online November 26, 2014, doi: 10.1177/0300985814559404

Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of salmonella typhimurium in the chicken. Bryony N Parsons, Paul Wigley, Hannah L Simpson, Jonathan M Williams, Suzie Humphrey, Anne-Marie Salisbury, Alastair J M Watson, Stephen C Fry, David O'Brien, Carol L Roberts, Niamh O'Kennedy, Asa V Keita, Johan D Söderholm, Jonathan M Rhodes, Barry J Campbell. PLoS One. 2014 Feb 3;9(2):e87658. doi: 10.1371/journal.pone.0087658

A Mouse Model of Pathological Small Intestinal Epithelial Cell Apoptosis and Shedding Induced by Systemic Administration of Lipopolysaccharide. Jonathan M. Williams, Carrie A. Duckworth, Alastair J. M. Watson, Mark R. Frey, Jennifer C. Miguel, Michael D. Burkitt, Robert Sutton, Kevin R. Hughes, Lindsay J. Hall, Jorge H Caamano, Barry J. Campbell, D. M. Pritchard. Disease Models and Mechanisms. November 2013   vol. 6  no. 6  1388-1399 PMID: 24046352

NF-κB signaling pathways differentially regulate Helicobacter felis induced gastric carcinogenesis in C57BL/6 mice.  Michael D Burkitt, Jonathan M Williams, Carrie A Duckworth, Adrian O’Hara, Abdalla Hanedi,Andrea Varro, Jorge H Caamaño, D Mark Pritchard. Oncogene. 2013 Dec 12;32(50):5563-73. doi: 10.1038/onc.2013.334

Gastric Helicobacter infection induces iron deficiency in the INS-GAS mouse.
Thomson MJ, Pritchard DM, Boxall SA, Abuderman AA, Williams JM, Varro A, Crabtree JE.
PLoS One. 2012;7(11):e50194. doi: 10.1371/journal.pone.0050194. Epub 2012 Nov 19

Host and environmental reservoirs of infection for bovine digital dermatitis treponemes.
Evans NJ, Timofte D, Isherwood DR, Brown JM, Williams JM, Sherlock K, Lehane MJ, Murray RD, Birtles RJ, Hart CA, Carter SD. Vet Microbiol. 2012 Apr 23;156(1-2):102-9. doi: 10.1016/j.vetmic.2011.09.029. Epub 2011 Oct 2

Pineocytoma in a Lowland Anoa (Bubalus depressicornis).
Jonathan Williams, Udo Hetzel, James Chatterton, Julian Chantrey,
J Comp Pathol. 2011 Feb-Apr;144(2-3):227-30. doi: 10.1016/j.jcpa.2010.08.011. Epub 2010 Oct 18.

Papillary tumor of the pineal region of a dog.
Williams JM, Michal U, Botteron C, Skerritt G, Hetzel U.
J Vet Diagn Invest. 2009 Nov;21(6):910-4.

Emerging canine angiostrongylosis in northern England: five fatal cases.
Y. Yamakawa, J. W. McGarry, D. Denk, J. Dukes-McEwan, N. Macdonald, A. Mas, F. McConnell, B. Tatton, E. G. Valentine, J. Wayne, J. M. Williams, and U. Hetzel
Vet Rec., Jan 2009; 164: 149 - 152.

Jonathan is the pathology IMR director and lectures on gastrointestinal, hepatic and pacreatic pathology. He also lectures on the principles and applications of pathology on the Bachelor of Veterinary Medicine, Bachelor of Biological Sciences and Bachelor of Comaparative Pathology courses. His teaching responsibilities include supervising Senior Clinical Training Scholars in Veterinary Pathology that are preparing for specialist qualifications in pathology and research students. He is also the Principles of Pathology unit organiser and deputy leader for the Imaging of Disease Module (BSc Biological Sciences), and deputy leader for the applications of pathology module for the BSc in comparative pathology.

Jonathan participates in the clinical surgical biopsy and post mortem diagnostic service of the RVC, and is involved in training the senior clinical training scholars in anatomic pathology.

Jonathan is a member of the of the British Society of Toxicological Pathology (BSTP) education sub-committee and scientific organiser for the BSTP Annual Scientific and Pathology of Mouse Models of Disease Meeting.

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