Department: Clinical Science and Services
Research Groups: Cardiovascular and Inflammation Biology and Metabolism
Clinical Groups: Small Animal Emergency and Critical Care
Research Centres: Clinical Investigation Centre
Dan is Professor of Emergency and Critical Care Medicine and Clinical Nutrition at the Royal Veterinary College. He is the interim Head of Department for Clinical Science and Services and most recently the Medical Director of the Queen Mother Hospital for Animals - Small Animal Referrals. He is also Director of the ECC Residency Programme and Intramural Rotations and Year 4 Leader of the BVetMed Programme .
Dan completed his BSc in Biology from the State University of New York, Geneseo in 1994. He graduated from Cornell University College of Veterinary Medicine in 1998. Following graduation he completed a Rotating Internship in Small Animal Medicine and Surgery at The Animal Medical Center, New York City. He became a Resident in Clinical Nutrition and in Emergency and Critical Care in 1999 at Tufts University School of Veterinary Medicine, North Grafton, MA. Following completion of his residency he became a Research Assistant Professor at Tufts, and came to the RVC in 2005. He became Section Head of the Emergency and Critical Care Services in 2008, Medical Director for the Queen Mother Hospital for Animals in 2016, and assumed the Interim Head of Department for Clinical Science and Services role in October 2018.
In 2010, he also become Editor-in-Chief of the Journal of Veterinary Emergency and Critical Care
Dan’s research interests centre around coagulation disorders, thromboelastography, platelet function assessment, and nutritional support of critically ill patients. Current research projects involve assessment of coagulation and fibrinolytic disorders.
Skulberg R, Cortellini S, Chan DL, Stanzani G, Jepson RE. Description of the use of plasma exchange in dogs with Cutaneous and Renal Glomerular Vasculopathy. Front Vet Sci 5:161 doi: 10.3389/fvets.2018.00161
Cole, L; Barfield, D; Chan, DL; Cortellini, S. The use of a modified thromboelastography assay for detection of hyperfibrinolysis in a dog infected with Angiostrongylus vasorum.Veterinary Record Case Reports 2018; 6: e000554. doi: 10.1136/vetreccr-2017-000554
Goggs, R; Borrelli A; Brainard BM; Chan, DL; de Laforcade AM; Goy-Thollot I; Jandrey KE; Kutter A; Kristensen AT; Rannou B; Sigrist N; Wagg C. Multicenter in vitro TEG-ROTEM standardization. J Vet Emerg Crit Care 2018;28(3):201-212. doi:10.1111/vec.12710
Doolin,KS, Chan DL, Adamantos S, Humm K. Retrospective evaluation of unexpected events during collection of blood donations performed with and without sedation in cats (2010-2013). J Vet Emerg Crit Care 2017; 27(5):555-560 (DOI: 10.1111/vec.12643)
Helm J, Coia M, Hammond G, Reeve L, Murtaugh K, Chan DL, Drees R, Walker D. Thoracic Computed Tomography Findings in Canine Angiostrongylosis in the UK. Vet Radiol & Ultrasound 2017;58(5):524-534(DOI: 10.1111/vru.12505)
Allenspach K, Culverwell C, Chan DL. Long-term outcome in dogs with chronic enteropathies: 203 cases. Vet Record, 2016 Jan 25. pii: vetrec-2015-103557. doi: 10.1136/vr.103557
Li R, Chan DL. Evaluation of platelet function using multiple electrode platelet aggregometry in dogs with septic peritonitis. J Vet Emerg Crit Care 2016; 26(5):630-8. doi: 10.1111/vec.12508
Hamzianpour N, Chan DL. Assessment of the contribution of platelets and clotting proteases via thromboelastography in the hypercoagulable state of dogs with immune-mediated hemolytic anemia. 2015; 25; doi: 10.1111/vec.12315
Stanzani G, Jepson RE, Chan DL. Management of acute kidney injury with continuous veno-venous hemodiafiltration in a cat. (JFMS Published Early View); doi: 10.1177/1098612X14541454
Jensen K, Chan, DL. Nutritional management of acute pancreatitis in dogs and cats. J Vet Emerg Crit Care 2014;24(3):240-50; doi: 10.1111/vec.12180
Goggs RA, Chan DL, Benigni L, Hirst C, Kellett-Gregory L, Luis Fuentes V. Comparison of computed tomography pulmonary angiography and point-of-care tests for pulmonary thromboembolism diagnosis in dogs. J Small Anim Pract 2014;55(4):109-117. doi: 10.1111/jsap.12185.
Hanel RM, Chan DL, Conner B, Gauthier V, Holowaychuk M, Istvan S, Walker J, Wood D, Goggs R, Wiinberg B. Systematic evaluation of evidence on Veterinary Viscoelastic Testing. Part 4: Definitions and Data Reporting. J Vet Emerg Crit Care 2014;24(1):47-56.
Chan, DL. Triage 2.0: Re-evaluation of early patient assessment. Editorial. J Vet Emerg Crit Care 2013;23(5):487-488
Gajanayake I, Wylie CE, Chan DL. Clinical Experience Using a Lipid-free, Ready-made Parenteral Nutrition Solution in Dogs: 70 cases (2006-2012). J Vet Emerg Crit Care 2013;23(3): 305-313.
Kellett-Gregory L, Adamantos S, Chan DL. Autologous red blood cell transfusions using cell salvage devices. J Vet Emerg Crit Care 2013; 23(1):82-86
Lewis DH, Chan DL, Pinheiro D, Armitage-Chan E, Garden OA. The immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response, and regulatory T cells. J Vet Intern Med. 2012;26(3):457-82.
Goggs, R; Wiinberg, B; Kjelgaard-Hansen, M; Chan, DL. Serial assessment of the coagulation status of dogs with immune-mediated haemolytic anaemia using thromboelastography. Veterinary Journal 2011; 191;3:347-353.
Goodwin LV, Goggs R, Chan DL, Allenspach K. Hypercoagulability in Dogs with Protein-Losing Enteropathy. J Vet Intern Med 2011; 25(2):273-7
Kjelgaard-Hansen M, Goggs R, Wiinberg B, Chan DL. Use of serum concentrations of interleukin-18 and monocyte chemoattractant protein-1 as prognostic indicators in primary canine immune-mediated hemolytic anemia. J Vet Intern Med 2011; 25(1):76-82.
Dunkel B, Chan DL, Boston R, Monreal L. Association between hypercoagulability and decreased survival in horses with ischemic or inflammatory gastrointestinal disease. J Vet Intern Med 2010;24(6):1467-74.
Humm K,Adamantos S, Benigni L, Armitage-Chan EA, Brockman DJ, Chan DL. Uterine rupture and septic peritonitis following dystocia and assisted delivery in a Great Dane bitch. Journal of the American Animal Hospital Association 2010;46:353-357.
Chan DL. The inappetent hospitalized cat. J Fel Med Surg. 2009;11(11):925-933
Gajanayake I, Chan DL. Nutritional Support of the Critical Patient. In Practice 2009;31:386-389.
Chan DL, Rozanski EA, Freeman LM. Relationship between plasma amino acids, c-reactive protein, illness severity and outcome in critically ill dogs. J Vet Intern Med 2009;23(3):559-563.
Goggs RA, Benigni L, Fuentes VL, Chan DL. Pulmonary thromboembolism. J Vet Emerg Crit Care 2009; 19(1):30-52.
GOGGS R, BOAG AK, CHAN DL.(2008) Concurrent immune-mediated haemolytic anaemia and severe thrombocytopenia in the dog: A retrospective study of 21 cases. Vet Record 163(11), 323-327.
WHELAN MF, O’TOOLE TE, CHAN DL, ROZANSKI EA, DELAFORCADE AM, CRAWFORD SL, COTTER SM. (In Press) Randomized, blinded, placebo-controlled trial of human intravenous immunoglobulin for treatment of canine immune-medicated haemolytic anaemia. JVECC.
TROW, A. V., ROZANSKI, E. A., DELAFORCADE, A. M. & CHAN, D. L. (2008) Evaluation of use of human albumin in critically ill dogs: 73 cases (2003-2006). J Am Vet Med Assoc 233, 607-612. PubMed ID 18710318
CHAN, D. L. (2008) The role of nutrients in modulating disease. J Small Anim Pract 49, 266-271. PubMed ID 18510496
CHAN, D. L. (2008) Colloids: current recommendations. Vet Clin North Am Small Anim Pract 38, 587-593, xi. PubMed ID 18402883
TORRE, D. M., DELAFORCADE, A. M. & CHAN, D. L. (2007) Incidence and clinical relevance of hyperglycemia in critically ill dogs. J Vet Intern Med 21, 971-975. PubMed ID 17939551
WALKER TG, CHAN DL, FREEMAN LM, ROZANSKI EA, DELAFORCADE AM, MILBURY PE, BLUMBERG JB. (2007) Serial determination of biomarkers of oxidative stress and antioxidant status in dogs with naturally occurring gastric dilatation-volvulus. J Vet Emerg Crit Care. 17(3):250-256.
ARMITAGE-CHAN EA, WETMORE LA, CHAN DL. (2007) Anesthetic Management of the Head Trauma Patient. J Vet Emerg Crit Care. 17(1):5-14.
CHAN, D. L. & FREEMAN, L. M. (2006) Nutrition in critical illness. Vet Clin North Am Small Anim Pract 36, 1225-1241, v-vi. PubMed ID 17085231
CHAN DL, FREEMAN LM, ROZANSKI EA, RUSH JE. (2006) Alterations in carbohydrate metabolism in critically ill cats. J Vet Emerg Crit Care. 16(S1): S7-S13.
CRABB SE, FREEMAN LM, CHAN DL, LABATO MA. (2006) Retrospective evaluation of total parenteral nutrition in cats: 40 cases (1991-2003). J Vet Emerg Crit Care. 16(S1):S21-S26.
ARMITAGE-CHAN EA, O’TOOLE T, CHAN DL. (2006) Management of Prolonged Food Deprivation, Hypothermia and Refeeding Syndrome in a Cat. J Vet Emerg Crit Care 16(S1): S34-S41.
CHAN, D. L. (2004) Nutritional requirements of the critically ill patient. Clin Tech Small Anim Pract 19, 1-5. PubMed ID 15025191
JOHNSON V, GAYNOR A, CHAN DL, ROZANSKI EA. (2004) Multiple organ dysfunction in people and dogs. J Vet Emerg Crit Care. 14(3):158-66.
HOLM JL, CHAN DL, ROZANSKI EA. (2003) Acute pancreatitis in dogs. J Vet Emerg Crit Care. 13(4):201-13.
CHAN, D. L., FREEMAN, L. M., LABATO, M. A. & RUSH, J. E. (2002) Retrospective evaluation of partial parenteral nutrition in dogs and cats. J Vet Intern Med 16, 440-445. PubMed ID 12141306
SPECHT A, CHAN DL, O’TOOLE T, KENT M, BENSON J, ROZANSKI EA, RUSH JE. (2002) Acute Staphylococcal peritonitis following cystocentesis in a dog. J Vet Emerg Crit Care. 12(3):183-187.
CHAN DL, ROZANSKI EA, FREEMAN LM, RUSH JE. (2001) Colloid osmotic pressure in health and disease. Compend Contin Educ Pract Vet. 23(10):896-904.
FREEMAN LM, CHAN DL. (2001) Enteral and Parenteral Nutrition. Compend Stand of Care: Emerg Crit Care Med. 3(8):1-7.
CHAN DL, FREEMAN LM, ROZANSKI EA, RUSH JE. (2001) Colloid osmotic pressure (COP) of parenteral nutrition components and intravenous fluids. J Vet Emerg Crit Care. 11(4): 269-74.
Dan’s teaching interest lies in emphasizing the need to consolidate medical issues with practical considerations in veterinary medicine. Dan focuses on challenging students with real-life scenarios, emphasising difficulties unrelated to medical problems, such as communication issues, professional issues, and managing limited resources. Dan lectures on topics related to professionalism, emergency and critical care and clinical nutrition. Dan is the Year Leader for Year 4 of the BVetMed Programme and BVetMed Rotations (IMR) Director.
Dan’s primary clinical interests involve management of critically ill patients, including those requiring mechanical ventilation, renal replacement therapy (dialysis, plasmapharesis) and interventional nutrition. Clinical syndromes with altered haemostasis such as sepsis, acute pancreatitis, and multiple organ dysfunction are another major area of interest. Dan also directs the Nutritional Support Service at the Queen Mother Hospital for Animals, and the Veterinary Trauma Centre.