Dr Lucie Bourne
Department: Comparative Biomedical Sciences
Research Groups: Musculoskeletal Biology
Departmental Technician for Comparative Biomedical Sciences
PhD in cell biology, specifically in vascular calcification and bone formation.
BSc (Hons) in Bioveterinary Sciences
Lucie has recently been appointed as a Departmental Technician to support research at the RVC, in particular, supporting laboratory and teaching activities within CBS.
Previously, Lucie undertook an RVC funded PhD studentship entitled: ''Comparision of the calcificaiton processes mediated by osteoblasts and vascular smooth muscle cells', which she completed and successfully defended in September 2020. During that time, she was awarded a New Investigator Award and a European Vascular Biology Organisation Travel Prize at the Bone Research Society Annual Meeting (Cardiff, 2019) and the ESM-EVBO meeting (Maastricht, 2019), respectively. In addition, Lucie was awarded ‘Most Outstanding Contribution to the Students' Union and to Student Life’ award (2020) for services to the RVC postgraduate community.
She also completed a BSc in Bioveterinary Sciences at the RVC and graduated with First Class Honours (2016). During her degree, she undertook a summer studentship with Dr Isabel Orriss and Prof. Caroline Wheeler-Jones on a project that involved “Developing new in vitro techniques for studying vascular calcification in human models”. It was during this time and during her dissertation, which investigated whether human umbilical artery smooth muscle cells (hVSMCs) could be used as a novel model of vascular calcification, that her interest in this field was established.
Lucie has been a BSc skills tutor at the college, a postgradute writing tutor, research group secretary and was the RVC Students' Union Postgraduate Officer for 2017-2020. She was also an active member of the RVC ladies 1s hockey team.
Bourne LE, Wheeler-Jones CPD, Orriss IR. (2020). Regulation of mineralisation in bone and vascular tissue: a comparative review. J Endocrinol. 20-0428
Patel JJ, Bourne LE, Thakur S, Farrington K, Gorog D, Orriss IR. (2020) 2- oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis. J Cell Physiol. 1-10.
Bourne LE, Orriss IR. (2019). Isolation and culture of primary osteoblasts. HubLE Methods 5. DOI: 10.13140/RG.2.2.30472.37127.
Patel JJ, Bourne LE, Millán JL, Arnett TR, MacRae VE, Wheeler-Jones CPD, Orriss IR. (2019). Inhibition of vascular smooth muscle cell calcification by ATP analogues. Purinergic Signal. 15(3):315-326
Bourne LE1 , Patel JJ1 , Davies BK, Arnett TR, MacRae VE, Wheeler-Jones CP, Orriss IR. (2019). Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts. Exp Cell Res. 380 100–113 1 Denotes joint-first authorship
Perpetuo, IP. Bourne, LE and Orriss, IR. (2019). Isolation and Generation of Osteoblasts, in Aymen I. Idris (ed.), Bone Research Protocols, Methods in Molecular Biology, vol. 1914
Patel JJ, Zhu D, Opdebeeck B, D'Haese P, Millán JL, Bourne LE, Wheeler-Jones CPD, Arnett TR, MacRae VE, Orriss IR. (2018). Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms. J Cell Physiol. 233(4):3230-324
Lucie is a member of the Bloomsbury Centre for Skeletal Research (BCSR) and has been involved with the BCSR New Investiagtors. As part of this group, she helped organsise outreach and public engagement talks to secondary school biology students.