Department: Comparative Biomedical Sciences
Research Groups: Brain Health and Behaviour
Dr Helen Stolp – Lecturer in Pharmacology
Helen studies mechanisms of normal and abnormal brain development, with the aim of producing targeted therapeutic and diagnostic tools. Identification of periods of plasticity and susceptibility in the developing brain, focused on early neurogenesis, angiogenesis, blood-brain barrier development and the cortex and the long-term consequence for cortical and hippocampal structure and function.
Helen Stolp graduated from the University of Tasmania with a Bachelor of Science (Honours) in 2001. She was awarded a Melbourne Research Scholarship and PhD position in the Department of Pharmacology, University of Melbourne in 2002, completed in 2006. She undertook post-doctoral research at the University of Melbourne, University of Oxford and King’s College London before being appointed to a lectureship at the Royal Veterinary College in London in 2017.
Helen was awarded a BRC STEM Early Career Award in 2013, and has been a member of the Steering Committee for the International Brain Barriers Society since 2012.
Helen’s research aims to understand the pathophysiology of neurodevelopmental injury, and to utilise this knowledge to target therapeutic and diagnostic tools. Her work has focused on the role of inflammation in normal and pathological neurodevelopment.
Research projects have been focused on the perinatal response to inflammation, and associated alterations in cortical development. These discoveries have relevance for our understanding of neurodevelopmental disorders such as autism and cerebral palsy. The group is pursuing novel therapies to ameliorate these injuries.
Helen is also collaborating with researchers at the University of Oxford and the Federal University of Rio de Janeiro to study the effect of ZIKA infection on neurovascular development and microcephaly, and changes in vascular susceptibility to injury during the period of brain development.
In addition, she is working with a team of MRI experts and computer scientists to establish a new pipeline for linking microstructural neuropathology with state-of-the-art MR imaging. This pipeline is being used to explore both the basic underpinning of MRI and develop disease targeted biomarkers.
Her research is currently supported by King’s Health Partners and Sparks Charity.
Stolp, H.B., Liddelow, S.A., Saunders, N.R. (2016). Editorial: Ontogeny and Phylogeny of Brain Barrier Mechanisms. Frontiers in Neuroscience. doi: 10.3389/fnins.2016.00041.
Stolp, H.B. and Z. Molnár (2015). Neurogenic niches in the brain: help and hindrance of the barrier systems. Frontiers in Neuroscience. doi:10.3389/fnins.2015.00020.
Baburamani, A. A., C. Hurling, H. Stolp, K. Sobotka, P. Gressens, H. Hagberg and C. Thornton (2015). Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury. Int J Mol Sci 16(9): 22509-22526.
Turnquist, C., Severson, D.T., Constaninescu, S.N., Ansorge, O., Stolp, H.B., Molnar, Z., Szele, F.G., Lu, X. (2013). STAT-1 induced ASPP2 transcription identifies a novel link between neuroinflammation, cell polarity and tumor suppression. PNAS. 111, 9834.
Evans, M.C., Gaillard, P., de Boer, M., Appeldoorn, C., Dorland, R., Sibson, N., Turner, M.R., Anthony, D.C. Stolp, H.B. (2014) CNS-targeted anti-inflammatory agent reduces pathology in mouse model of ALS (2014). Acta Neuropathologica Comm. 2, 66.
Evans, M.C., Serres, S., Shrapichef, A., Stolp, H.B., Anthony, D.C., Talbert, K., Turner, M.R., Sibson, N. (2014). The nature and timing of brainstem MRI changes in the SOD1 mouse model of Amyotrophic Lateral Sclerosis. J. Cereb. Metab and Blood Flow. 34, 785.
Stolp, H.B. (2012). Neuropoietic cytokines in normal brain development and neurodevelopmental disorders. MCN. Doi:10.1016/j.mcn.2012.08.009.
Stolp, H. B., C. Turnquist, K. M. Dziegielewska, N. R. Saunders, D. C. Anthony and Z. Molnar (2011). Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse. Brain 134(Pt 11): 3236-3248.
Stolp, H. B., C. J. Ek, P. A. Johansson, K. M. Dziegielewska, A. M. Potter, M. D. Habgood and N. R. Saunders (2007). Effect of minocycline on inflammation-induced damage to the blood-brain barrier and white matter during development. Eur J Neurosci 26(12): 3465-3474.
Stolp, H. B., K. M. Dziegielewska, C. J. Ek, A. M. Potter and N. R. Saunders (2005). Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat. Eur J Neurosci 22(11): 2805-2816.
Stolp, H. B., K. M. Dziegielewska, C. J. Ek, M. D. Habgood, M. A. Lane, A. M. Potter and N. R. Saunders (2005). Breakdown of the blood-brain barrier to proteins in white matter of the developing brain following systemic inflammation. Cell Tissue Res 320(3): 369-378.