Dr Warboys is interested in the initiation and development of cardiovascular disease, in particular how mechanical forces (such as shear stress) control the spatial localisation of atherosclerosis, that specifically occurs in regions of disturbed shear stress. She is interested in the mechanical regulation of the Wnt/β-catenin signalling pathway in endothelial cells and her particular focus is on how β-catenin mechanosignalling regulates inflammation and permeability. She is also interested in the crosstalk between flow-mediated endothelial dysfunction and diabetic endothelial dysfunction with a view to understanding the increased cardiovascular risk in diabetic patients.

Current student: Miss Anna McQueen (PhD project: Development of an in vitro model to investigate the interplay between haemodynamic factors and a diabetic microenvironment on endothelial function)

Publications

McQueen A & Warboys CM. Mechanosignalling pathways that regulate endothelial barrier function. Current Opinion in Cell Biology 2023 (accepted, in press). Review

Rickman M, Ghim M, Pang K, von Huelsen Rocha AC, Drudi E, Sureda-Vives M, Ayoub N, Tajadura-Ortega V, George SJ, Weinberg PD, Warboys CM. Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin dependent pathway. Journal of Cell Science 2023; 136(6): jcs260449.

Pang K, Ghim M, Sarathchandra P, Chester A, Yacoub M, Warboys CM, Weinberg PD. Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications 2023; 642: 90-96.

Ghim M, Yang S-W, David KZR, Eustaquio J, Warboys CM, Weinberg PD. NO synthesis but not apoptosis, mitosis or inflammation can explain correlations between flow directionality and paracellular permeability of cultured endothelium. International Journal of Molecular Sciences 2022; 23(15): 8076.

Warboys CM & Weinberg PD. S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability. Tissue Barriers 2021

Pang K, Ghim M, Liu C, Tay HM, Fhu CW, Chia RN, Qiu B, Sarathchandra P, Chester A, Yacoub M, Wilkinson F, Weston R, Warboys CM, Hou HW, Weinberg PD, Wang X. Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor. Frontiers in Cell and Developmental Biology 2021; 9: 706143

Tajadura, V; Hansen, MH; Smith, J; Charles, H; Rickman, M; Farrell-Dillon, K; Claro, V; Warboys, CM; Ferro, A
β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression
Cell Death & Disease, 11: 493 (2020).  

Warboys CM, Ghim M, Weinberg PD. Understanding mechanobiology in cultured endothelium. A review of the orbital shaker method. Atherosclerosis 2019. DOI: https:// doi.org/10.1016/j.atherosclerosis.2019.04.210.

Warboys CM. Mechanoactivation of Wnt/ β-catenin pathways in health and disease. Emerging Topics in Life Sciences 2018; 2(5):701-712. Review. DOI: 10.1042/ETLS20180042

Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys CM, Krams R. New developments in mechanotransduction: Crosstalk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress. Current Opinion in Biomedical Engineering 2018; 5:96-104. Review. DOI: https://doi.org/10.1016/j.cobme.2018.03.003

Serbanovic-Canic J, De Luca A, Warboys CM, Hsiao S, Feng S, Luong L, Mahmoud M, Gauci I, Firmin D, Ferreira P, Walczak H, Ridger V, Krams R, Mason JC, Haskard DO, Sherwin S, Chico TJA, Evans PC. Zebrafish model for functional screening of flow-responsive genes.  Arteriosclerosis Thrombosis and Vascular Biology 2017; 37:130-143. DOI: 10.1161/ATVBAHA.116.308502

Passacquale G, Phinikaridou A, Warboys CM, Alfieri A, Marcelo E. Andia ME, Botnar RM, Ferro A. Aspirin-induced histone acetylation in endothelial cells enhances synthesis of the secreted isoform of netrin-1 thus inhibiting monocyte vascular infiltration.  British Journal of Pharmacology 2015; 172(14):3548-64. DOI: 10.1111/bph.13144

Warboys CM, Chen N, Zhang Q, Shaifta Y, Vanderslott V, Passacquale P, Hu Y, Xu Q, Ward JPT, Ferro A. Bidirectional cross-regulation between the eNOS and β-catenin signalling pathways.  Cardiovascular Research 2014; 104(1): 116-126. DOI: 10.1093/cvr/cvu173

Amini N, Malik T, Boyle JJ, Warboys CM, Zakkar M, Mason JC, Haskard D, Evans PC. Requirement of JNK1 for endothelial cell injury in atherogenesis. Atherosclerosis 2014; 235(2): 613-618. DOI: 10.1016/j.atherosclerosis.2014.05.950.

Warboys CM, de Luca A, Amini, N, Luong L, Duckles H, Hsiao S, White A, Biswas S, Khamis R, Chong CK, Cheung WM, Sherwin SJ, Bennet MR, Gil J, Mason JC, Haskard DO, Evans PC. Disturbed flow promotes endothelial senescence via a p53-dependent pathway.  Arteriosclerosis Thrombosis and Vascular Biology 2014; 34(5): 985-995. DOI:   10.1161/ATVBAHA.114.303415.

Warboys CM, Overby DR, Weinberg PD. Dendritic cells lower the permeability of endothelial monolayers. Cellular and Molecular Bioengineering 2012; 5(2):184-193. DOI: https://doi.org/10.1016/j.atherosclerosis.2010.08.040

Warboys CM, Amini N, de Luca A, Evans PC. The role of blood flow in determining the sites of atherosclerotic plaques. F1000 Medicine Reports 2011; 3:5-12. Review. DOI: 10.3410/M3-5

Potter CMF, Lundberg MH, Harrington LS, Warboys CM, Warner TD, Berson RE, Moshkov AV, Gorelik J, Weinberg PD, Mitchell JA. Role of shear stress in endothelial cell morphology and expression of cyclo-oxygenase isoforms. Arteriosclerosis Thrombosis and Vascular Biology 2011; 31(2):384-91. DOI: 10.1161/ATVBAHA.110.214031.

Warboys CM, Berson RE, Mann GE, Pearson JD, Weinberg PD. Acute and chronic exposure to shear stress have opposite effects on endothelial permeability to macromolecules. American Journal of Physiology (Heart Circ. Physiol.) 2010; 298:1850-1856. DOI: 10.1152/ajpheart.00114.2010

Warboys CM, Fraser PA. Hyperglycaemia attenuates acute permeability response to AGEs in retinal microvasculature. Microvascular Research 2010; 80:174-176. DOI: 10.1016/j.mvr.2010.03.004

Warboys CM, Toh H-B, Fraser PA. Role of NADPH oxidase in retinal microvascular permeability increase by RAGE activation.  Investigative Ophthalmology & Visual Science 2009; 50(3):1319-28. DOI: 10.1167/iovs.08-2730

 

 

Christina obtained a Postgraduate Certificate in Veterinary Education in 2021 and is a Fellow of the Higher Education Academy

Christina co-leads the BSc1 Biology of the Cell and BSc3 Comparative Models of Disease modules. She also teaches on these modules giving lectures on cell membranes and cytoscaffolds and comparative models of atherosclerosis, respectively. She also teaches cardiovascular endocrinology on the BSc3 Endocrine & Metabolic Syndromes module.

Christina is also a tutor for BVM and BSc students.