Department: Comparative Biomedical Sciences
Research Groups: Cardiovascular and Inflammation Biology and Metabolism
Dr Caroline Pellet-Many is a lecturer in Biomedical Sciences with a particular interest in Cardiovascular Biology. She teaches on the BVetMed and on the BSc in Biological Sciences degrees and is a Fellow of the Higher Education Academy.
Dr Pellet-Many studied in France (Universite Louis Pasteur, Strasbourg) for her undergraduate and post-graduate (Maitrise) in Biology. She also obtained and MSc in Physiology with Distinctions from Birkbeck College and completed her PhD in University College London in 2010. Subsequently, she worked as a post-doctoral scientist in the Centre for Cardiovascular Biology with Prof. Ian Zachary in UCL before joining the Royal Veterinary College in 2018.
She is a fellow of the Higher Education Academy (PGCertTLHE), and teaches on various courses, including Cardiovascular Physiology, Cellular and Molecular Biology.
Dr Pellet-Many is interested in understanding the gene regulation as well as the molecular and cellular processes leading to cardiovascular diseases. In particular, she has expertise in in vivo models to study how smooth muscle cells play a role in the build-up of atherosclerotic plaque in arteries. She also uses the zebrafish model of cardiac regeneration to investigate the role of the epicardium and the endocardium (the outer and inner layer of the heart) in cardiac regeneration and the fin regeneration model to study angiogenesis.
- Mehta V., Fields L., Evans I.M., Yamaji M., Pellet-Many C., Jones T., Mahmoud M., and Ian Zachary (2018) VEGF induces Neuropilin-1 (NRP1) cleavage via ADAMs 9 and 10 to generate novel Carboxy-terminal NRP1 fragments that regulate angiogenic signalling. ATVB, 38(8): 1845-1858.
- Pellet-Many, C., Lowe, V., Sayers, J., & Zachary, I. (2018). Neuropilin 1 mediates epicardial activation and revascularisation of the regenerating zebrafish heart. Presented at: 5th Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology.
- Critchley W. R., Pellet-Many C., Ringham-Terry B., Harrison M. A., Zachary I. C., Ponnambalam, S. (2018). Receptor tyrosine kinase ubiquitination and de-ubiquitination in signal transduction and receptor trafficking. Cells, 7(3).
- Pellet-Many, C., Mehta, V., & Zachary, I. (2016). NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo. Presented at: Frontiers in CardioVascular Biology Meeting (FCVB).
- Lowe, V., Pellet-Many, C., & Zachary, I. (2016). Role of neuropilins in zebrafish heart regeneration. Presented at: Frontiers in CardioVascular Biology Meeting (FCVB).
- Pellet-Many C*#, Mehta V*, Fields L, Mahmoud M, Lowe V, Evans IM, Ruivo J, Zachary IC# (2015) Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialisation following arterial injury. Cardiovasc Res. 108(2): 288-298, Co-first* and co-corresponding# author.
- Pellet-Many C (2015) Chemotactic migration of endothelial cells towards VEGF-A165 inL Fiedler L ed. VEGF signalling Springer Protocols, Methods Mol Biol; 1332:151-7.
- Jopling HM, Odell AF, Pellet-Many C, Latham AM, Frankel P, Sivaprasadarao A, Walker JH, Zachary IC, Ponnambalam S. (2014) Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation. Cells 29;3(2):363-85.
- Barrett A, Evans IM, Frolov A, Britton G, Pellet-Many C, Yamaji M, Mehta V, Bandopadhyay R, Li N, Brandner S, Zachary IC, Frankel P. (2014) A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling. J Cell Sci. 15;127(Pt 12):2647-58.
- Barrett A, Pellet-Many C, Zachary IC, Evans IM, Frankel P (2012) p130Cas: A key signalling node in health and disease. Cellular Signalling. 25(4):766-777.
- Bruns AF, Yuldasheva N, Latham AM, Caroline Pellet-Many C, Bao L, Frankel P, Stephen SL, Howell GJ, Wheatcroft SB, Kearney MT, IC, Ponnambalam S (2012) A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS ONE 7(11): e48539. doi:10.1371/journal.pone.0048539
- Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC. (2011) VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation. Molecular Biology of the Cell. 22(15):2766-76.
- Pellet-Many C, Frankel P, Evans IM, Herzog B, Jünemann-Ramírez M, Zachary IC. (2011) Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. Biochemical Journal. 435(3):609-18.
- Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Molecular and Cellular Biology. 31(6):1174-85.
- Zachary IC, Frankel P, Evans IM, Pellet-Many C. (2009) The role of neuropilins in cell signalling. Biochemical Society Transactions. 37(Pt 6):1171-8.
- Frankel P, Pellet-Many C, Lehtolainen P, D'Abaco GM, Tickner ML, Cheng L, Zachary IC. (2008) Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway. Embo Reports. 9(10):983-9.
- Pellet-Many C, Frankel P, Jia H, Zachary I. (2008) Neuropilins: structure, function and role in disease. Biochemical Journal. 411(2):211-26.
Dr Pellet-Many is a tutor for Biological Sciences BSc and BVetMed students and teaches Cardiovascular Biology to first year BSc students.
For the past 7 years, she has been running a very successful technique workshop sponsored by the Phsyiological Society, teaching physiologists basic laboratory techniques in Molecular Biology.
Dr Caroline Pellet-Many runs a workshop sponsored by the Physiological Society, teaching participants essential laboratory skills and Molecular Biology techniques.
She reaches out to primary schools to promote a healthy cardiovascular lifestyle on behalf of the BHF.