Morris Animal Foundation Canine Cancer Epidemiology Research Programme (In progress)

People: David Brodbelt, Dan O'Neill, Sandra Guillen, Collette Taylor

Dates: October 2023 - October 2026 

Background 

 

Cancer is a significant cause of morbidity and mortality in dogs. Improved understanding of canine cancer epidemiology is important from both veterinary and human health perspectives, as certain cancers exhibit similarities between dogs and humans (Dobson et al., 2013). Additionally, dogs and humans are exposed to the same potential risk factors due to similarities in environmental and lifestyle exposures (Dobson et al.,2013).  

Breed associations appears to vary, with some studies reporting Golden Retrievers (among other breeds) to be at increased cancer risk (Boerkamp et al., 2014; Kent et al.,2018). In light of this, the Morris Animal Foundation established a lifetime cohort of Golden Retrievers in the US (GRLS), which is now nearing the end of its life (Guy et al., 2015). This project aims to explore the frequency of different cancers and factors associated with these cancers in dogs from the GRLS cohort. Alongside this, VetCompass health data will be examined to explore cancer frequency and risk factors in both Golden Retrievers and the wider, UK primary-practice attending population. 

The project will focus initially on haemangiosarcoma, mast cell tumour and lymphoma in dogs. 

Broad aims of the project:

  • Identify, and estimate the frequency of, the major cancers of the GRLS cohort and dogs in the VetCompass primary care population 

  • Explore potential associations between signalment, lifestyle and environmental factors with a canine cancer diagnosis 

  • Estimate the survival time from diagnosis for main canine cancers 

  • Explore potential associations between signalment, lifestyle and environmental factors with survival 

References:

Dobson J. M. (2013). Breed-predispositions to cancer in pedigree dogs. ISRN veterinary science, 2013, 941275. https://doi.org/10.1155/2013/941275 

Boerkamp KM, Teske E, Boon LR, Grinwis GC, van den Bossche L, Rutteman GR (2014). Estimated incidence rate and distribution of tumours in 4,653 cases of archival submissions derived from the Dutch golden retriever population. BMC Vet Res. 2014;10:34. Epub 2014/02/04. pmid:24484635; PubMed Central PMCID: PMCPMC3914708. 

Kent MS, Burton JH, Dank G, Bannasch DL, Rebhun RB (2018). Association of cancer-related mortality, age and gonadectomy in golden retriever dogs at a veterinary academic center (1989-2016). PLOS ONE 13(2): e0192578. https://doi.org/10.1371/journal.pone.0192578 

Guy, M. K., Page, R. L., Jensen, W. A., Olson, P. N., David Haworth, J., Searfoss, E. E., & Brown, D. E. (2015). The golden retriever lifetime study: Establishing an observational cohort study with translational relevance for human health. In Philosophical Transactions of the Royal Society B: Biological Sciences (Vol. 370, Issue 1673). Royal Society of London. https://doi.org/10.1098/rstb.2014.0230 

Funding Partners

This project is funded by the Morris Animal Foundation.

Dates: October 2023 - August 2024

Background 

Over the last decade, Morris Animal Foundation (MAF) has established a lifetime cohort of Golden Retrievers (GRLS) in the US (Guy et al. 2015). This cohort is now nearing the end of its life and has identified haemangiosarcoma as a major tumour of this breed.  Describing the clinical management and identifying signalment and lifestyle risk factors for haemangiosarcoma in this common breed could help understand the nature and progression of this important cancer. This MRes project aims to evaluate major animal and lifestyle risk factors for haemangiosarcoma in Golden Retrievers and contextualise these findings in the wider dog population within VetCompass.

 

Study objectives

  1. To estimate the frequency of haemangiosarcoma in the dogs in the UK within VetCompass
  2. Identify major breed associations for diagnosis of haemangiosarcoma in the UK
  3. Evaluate lifestyle and animal factors for haemangiosarcoma in Golden Retrievers in the Golden Retriever lifetime cohort

 

Method

Using the GRLS cohort of approximately 3,000 Golden Retrievers with a complete life history, the incidence of haemangiosarcoma will be estimated. Diagnosis will be based on owner reported cancer confirmed by veterinary diagnosis and evidence of further tests and animal and lifestyle risk factors explored. Risk factors exploration will be derived from data from the yearly owner and veterinarian questionnaires and will focus on animal life style (diet, activity, home environment).

In the VetCompass study, cases of haemangiosarcoma will be identified from the electronic health records of dogs under veterinary care within VetCompass during 2019. Cases of haemangiosarcoma will be defined based on a clinical diagnosis and presence of histological evidence. Incidence of haemangiosarcoma will be estimated and signalment risk factors for diagnoses evaluated.

In both studies, risk factors will be explored in multivariable logistic regression models. Statistical significance will be set at the 5% level.

 

References

Guy, M. K., R. L. Page, W. A. Jensen, P. N. Olson, J. D. Haworth, E. E. Searfoss and D. E. Brown (2015). "The Golden Retriever Lifetime Study: establishing an observational cohort study with translational relevance for human health." Philosophical Transactions of the Royal Society of London B: Biological Sciences 370(1673).

Project funders

This project is funded by the Morris Animal Foundation.

Vet Compass Project Type: Dog

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