Department: Pathology and Pathogen Biology

Campus: Camden

Research Groups: Host-Pathogen Interactions and Vaccinology

Sharon is a Lecturer in Microbiology and a member of the Infection & Immunity research programme. Her research interests are mechanisms of transcriptional regulation in bacteria including the pathogenic bacterium Mycobacterium tuberculosis. She is trying to understand how Mtb adapts in order to survive within the host for extended periods of time.

Sharon completed a BSc in Genetics at the University of Swansea and a PhD in antibiotic resistance in E. coli at the University of Bristol. Her PhD studies looked at the phenomenon of antibiotic tolerance - a process whereby bacterial growth is inhibited by the presence of the antibiotics but survival and regrowth is observed on removal. She began to start work as a Post-Doctoral Fellow with Mycobacterium tuberculosis in 2000 first at the London School of Hygiene and Tropical Medicine and subsequently at The Royal Veterinary College. During her post-doctoral studies she developed an interest in gene regulation and continues to pursue this interest. She was appointed as a Lecturer in Microbiology in 2007.

Sharon is interested in transcriptional regulation in Mycobacteria and uses gene expression analysis, DNA sequence analysis and binding studies in order to try to identify which genes are controlled by which transcriptional regulators and how signals from the host environment switch on particular gene networks. Through an understanding of these networks she is hoping to identify ways in which crucial groups of genes are involved in pathogenesis and how these can be interfered with to be switched off. Her collaborators include the Bacterial Microarray Group at St Georges Hospital Medical school (BUG@S).

Balhana, R., Stoker, N. G., Sikder, M. H., Chauviac, F. X. & Kendall, S. L. (2010). Rapid construction of mycobacterial mutagenesis vectors using ligation-independent cloning. J Microbiol Methods 83, 34-41.

Kendall, S. L., P. Burgess, R. Balhana, M. Withers, A. Ten Bokum, J. S. Lott, C. Gao, I. Uhia-Castro & N. G. Stoker, (2009) Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2. Microbiology 156: 1362-1371.

Sharpe, M. L., C. Gao, S. L. Kendall, E. N. Baker & J. S. Lott, (2008) The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis. J Mol Biol 383: 822-836.

Senaratne, R. H., B. Sidders, P. Sequeira, G. Saunders, K. Dunphy, O. Marjanovic, J. R. Reader, P. Lima, S. Chan, S. Kendall, J. McFadden & L. W. Riley, (2008) Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice. J Med Microbiol 57: 164-170.

Sidders, B., M. Withers, S. L. Kendall, J. Bacon, S. J. Waddell, J. Hinds, P. Golby, F. Movahedzadeh, R. A. Cox, R. Frita, A. M. Ten Bokum, L. Wernisch & N. G. Stoker, (2007) Quantification of global transcription patterns in prokaryotes using spotted microarrays. Genome Biol 8: R265.

Kendall, S. L., M. Withers, C. N. Soffair, N. J. Moreland, S. Gurcha, B. Sidders, R. Frita, A. Ten Bokum, G. S. Besra, J. S. Lott & N. G. Stoker, (2007) A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol Microbiol 65: 684-699.

Bacon, J., L. G. Dover, K. A. Hatch, Y. Zhang, J. M. Gomes, S. Kendall, L. Wernisch, N. G. Stoker, P. D. Butcher, G. S. Besra & P. D. Marsh, (2007) Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Microbiology 153: 1435-1444.

Campbell, D. R., K. E. Chapman, K. J. Waldron, S. Tottey, S. Kendall, G. Cavallaro, C. Andreini, J. Hinds, N. G. Stoker, N. J. Robinson & J. S. Cavet, (2007) Mycobacterial cells have dual nickel-cobalt sensors: sequence relationships and metal sites of metal-responsive repressors are not congruent. J Biol Chem 282: 32298-32310.

Sardiwal, S., S. L. Kendall, F. Movahedzadeh, S. C. Rison, N. G. Stoker & S. Djordjevic, (2005) A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem. J Mol Biol 353: 929-936.

Hu, Y., S. Kendall, N. G. Stoker & A. R. Coates, (2004) The Mycobacterium tuberculosis sigJ gene controls sensitivity of the bacterium to hydrogen peroxide. FEMS Microbiol Lett 237: 415-423.

Kendall, S. L., F. Movahedzadeh, S. C. Rison, L. Wernisch, T. Parish, K. Duncan, J. C. Betts & N. G. Stoker, (2004) The Mycobacterium tuberculosis dosRS two-component system is induced by multiple stresses. Tuberculosis (Edinb) 84: 247-255.

Kendall, S. L., S. C. Rison, F. Movahedzadeh, R. Frita & N. G. Stoker, (2004) What do microarrays really tell us about M. tuberculosis? Trends Microbiol 12: 537-544.

Movahedzadeh, F., S. C. Rison, P. R. Wheeler, S. L. Kendall, T. J. Larson & N. G. Stoker, (2004) The Mycobacterium tuberculosis Rv1099c gene encodes a GlpX-like class II fructose 1,6-bisphosphatase. Microbiology 150: 3499-3505.

Movahedzadeh, F., D. A. Smith, R. A. Norman, P. Dinadayala, J. Murray-Rust, D. G. Russell, S. L. Kendall, S. C. Rison, M. S. McAlister, G. J. Bancroft, N. Q. McDonald, M. Daffe, Y. Av-Gay & N. G. Stoker, (2004) The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol Microbiol 51: 1003-1014.

Parish, T., D. A. Smith, S. Kendall, N. Casali, G. J. Bancroft & N. G. Stoker, (2003) Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis. Infect Immun 71: 1134-1140.

Wernisch, L., S. L. Kendall, S. Soneji, A. Wietzorrek, T. Parish, J. Hinds, P. D. Butcher & N. G. Stoker, (2003) Analysis of whole-genome microarray replicates using mixed models. Bioinformatics 19: 53-61.

Kendall, S. L., F. Movahedzadeh, A. Wietzorrek & N. G. Stoker, (2002) Microarray analysis of bacterial gene expression: towards the regulome. Comp Funct Genomics 3: 352-354.

Book Chapters

Kendall, S. L. & R. Frita, (2008) Construction of targeted mycobacterial mutants by homologous recombination. In: Mycobacterial Protocols T. Parish & A. C. Brown (eds). Humana Press., pp. 121-135.

Rison, S. C. G., S. L. Kendall, F. Movahedzadeh & N. G. Stoker, (2005) The mycobacterial two-component regulatory systems. . In: Mycobacterium molecular microbiology T. Parish (ed). Horizon Bioscience, pp. 29-69.

Pashley, C. & S. Kendall, (2003) Cloning in plasmid vectors. In: E. coli Plasmid Vectors N. Casali & A. Preston (eds). Humana Press., pp. 121-135.

Sharon teaches on the BSc BioVeterinary Science course, the Gateway to Veterinary Medicine course and the BVetMed course. She has also completed a Post Graduate Certificate in Veterinary Education and is a Fellow of the Higher Education Academy (FHEA). She supervises PhD students and undegraduate research projects.

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