I am interested in the genetic basis of virulence in members of the MTBC, causative agents of TB in both humans and animals. I am using whole genome fitness screens to assess the phenotypic consequences of insertions on the ability of pathogenic mycobacteria to survive in the host. I am also interested in the genetic basis of host preference in members of the MTBC and the functional consequences of the large scale and single nucleotide polymorphisms that exist between different members and in field strains. I have worked with mycobacteria for over two decades and I have been funded by the BBSRC, The Royal Society, and the International Veterinary Vaccinology Network.   
  

Publications:

1. Gaupool B, Glenn SM, Milburn E, Turapov O, Crosatti M, Hincks J, Stewart B, Bacon J, Kendall SL, Voskuil M, Riabova O, Monakhova N, Green J, Waddell SJ, Makarov, VA, Mukamolova, GV (2024) Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis. Communication Biology https://doi.org/10.1038/s42003-024-06912-0.
2. Roberts AH, Moon CW, Faulkner V, Kendall SL, Waddell SJ, Bacon J. EfpA is required for regrowth of Mycobacterium tuberculosis following isoniazid exposure (2024). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00261-24
3. Stiens J, Tan YY, Joyce R, Arnvig KB, Kendall SL, Nobeli I (2023). Using a Whole Genome Co-expression Network to Inform the Functional Characterisation of Predicted Genomic Elements from Mycobacterium tuberculosis. Molecular Microbiology. https://doi.org/10.1111/mmi.15055.
4. Asai M, Li Y, Spiropoulos J, Cooley W, Everest D, Kendall S, Martin C, Robertson B, Langford P, Newton S (2022). Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv. Virulence. https://doi.org/10.1080/21505594.2022.2119657.
5. Stiens J, Arnvig KB, Kendall SL, Nobeli I (2022). Challenges in defining the functional, non-coding, expressed genome of members of the Mycobacterium tuberculosis complex. Molecular Microbiology. https://doi.org/10.1111/mmi.14862.
6. Gibson AJ, Stiens J, Passmore IJ, Faulkner V, Miculob J, Willcocks S, Coad M, Berg S, Werling D, Wren BW, Nobeli I, Villarreal-Ramos B, Kendall SL (2022). Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria. mBio. https://doi.org/10.1128/mbio.00672-22.
7. Gibson AJ, Passmore IJ, Faulkner V, Xia D, Nobeli I, Stiens J, Willcocks S, Clark TG, Sobowiak B, Werling D, Villarreal-Ramos B, Wren BW and Kendall SL (2021). Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of the Mycobacterium tuberculosis Complex Using TnSeq. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.760717.
8. Schuller M, Butler RE, Ariza A, Tromans-Coia C, Jankevicius G, Claridge TDW, Kendall SL, Goh S, Stewart GR, Ahel I (2021). Molecular basis for DarT ADP-ribosylation of a DNA base. Nature. doi: 10.1038/s41586-021-03825-4.  
9. Faulkner V, Cox AA, Goh S, van Bohemen A, Gibson AJ, Liebster O, Wren BW, Willcocks S, Kendall SL (2020). Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits. Frontiers in Microbiology https://doi.org/10.3389/fmicb.2020.619427
10. Perrone F, De Siena B, Muscariello L, Kendall SL, Waddell SJ, Sacco M (2017). A Novel TetR-like transcriptional regulator is induced in acid-nitrosative stress and controls expression of an efflux pump in mycobacteria. Frontiers in Microbiology https://doi.org/10.3389/fmicb.2017.02039
11. Kamaruzzaman NF, Kendall S, and Good L: Targeting the hard to reach: challenges and novel strategies in the treatment of intracellular bacterial infections. British Journal of Pharmacology 2016, 174(14): 2225-2236
12. Ho NA, Dawes SS, Crowe AM, Casabon IE, Gao C, Kendall SL, Baker EN, Eltis LD, Lott JS: The structure of the transcriptional repressor Kstr in complex with CoA thioester cholesterol metabolites sheds light on the regulation of cholesterol catabolism in Mycobacterium tuberculosis. The Journal of biological chemistry 2016, 291:7256-7266.
13. Mbugi EV, Katale BZ, Siame KK, Keyyu JD, Kendall SL, Dockrell HM, Streicher EM, Michel AL, Rweyemamu MM, Warren RM et al: Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania. Tuberculosis 2015, 95(2):170-178.
14. Balhana RJ, Singla A, Sikder MH, Withers M, Kendall SL: Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions. BMC genomics 2015, 16:479.
15. Katale BZ, Mbugi EV, Botha L, Keyyu JD, Kendall S, Dockrell HM, Michel AL, Kazwala RR, Rweyemamu MM, van Helden P et al: Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania. BMC Infect Dis 2014, 14(1):616.
16. Evangelopoulos D, Gupta A, Lack NA, Maitra A, ten Bokum AM, Kendall S, Sim E, Bhakta S: Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis. Tuberculosis 2014, 94(6):664-671.
17. Dawes SS, Kendall SL, Baker EN, Lott JS: Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (ketosteroid regulatory protein) from Mycobacterium tuberculosis. Acta Crystallographica Section F-Structural Biology Communications 2014, 70:1643-1645.
18. Katale BZ, Mbugi EV, Karimuribo ED, Keyyu JD, Kendall S, Kibiki GS, Godfrey-Faussett P, Michel AL, Kazwala RR, van Helden P et al: Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania. BMC Vet Res 2013, 9:267.
19. Balhana RJ, Swanston SN, Coade S, Withers M, Sikder MH, Stoker NG, Kendall SL: bkaR is a TetR-type repressor that controls an operon associated with branched-chain keto-acid metabolism in Mycobacteria. FEMS Microbiol Lett 2013, 345(2):132-140.
20. Uhia I, Galan B, Kendall SL, Stoker NG, Garcia JL: Cholesterol metabolism in Mycobacterium smegmatis. Environmental Microbiology Reports 2012, 4(2):168-182.
21. Mbugi EV, Kayunze KA, Katale BZ, Kendall S, Good L, Kibik GS, Keyyu JD, Godfrey-Faussett P, Van Helden P, Matee MI: 'One Health' infectious diseases surveillance in Tanzania: are we all on board the same flight? Onderstepoort J Vet Res 2012, 79(2):500.
22. Mbugi EV, Katale BZ, Kendall S, Good L, Kibiki GS, Keyyu JD, Godfrey-Faussett P, Van Helden P, Matee MI: Tuberculosis cross-species transmission in Tanzania: towards a One-Health concept. Onderstepoort J Vet Res 2012, 79(2):501.
23. Katale BZ, Mbugi EV, Kendall S, Fyumagwa RD, Kibiki GS, Godfrey-Faussett P, Keyyu JD, Van Helden P, Matee MI: Bovine tuberculosis at the human-livestock-wildlife interface: is it a public health problem in Tanzania? A review. Onderstepoort J Vet Res 2012, 79(2):463.
24. Balhana R, Stoker NG, Sikder MH, Chauviac FX, Kendall SL: Rapid construction of mycobacterial mutagenesis vectors using ligation-independent cloning. J Microbiol Methods 2010, 83(1):34-41.
25. Kendall SL, Frita R: Construction of targeted mycobacterial mutants by homologous recombination. Methods Mol Biol 2009, 465:297-310.
26. Kendall SL, Burgess P, Balhana R, Withers M, Ten Bokum A, Lott JS, Gao C, Uhia-Castro I, Stoker NG: Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2. Microbiology 2009, 156(5):1362-1371.
27.  Sharpe ML, Gao C, Kendall SL, Baker EN, Lott JS: The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis. J Mol Biol 2008, 383(4):822-8
28. Senaratne RH, Sidders B, Sequeira P, Saunders G, Dunphy K, Marjanovic O, Reader JR, Lima P, Chan S, Kendall S et al: Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice. J Med Microbiol 2008, 57(2):164-170.
29. Sidders B, Withers M, Kendall SL, Bacon J, Waddell SJ, Hinds J, Golby P, Movahedzadeh F, Cox RA, Frita R et al: Quantification of global transcription patterns in prokaryotes using spotted microarrays. Genome Biol 2007, 8(12):265.
30. Kendall SL, Withers M, Soffair CN, Moreland NJ, Gurcha S, Sidders B, Frita R, Ten Bokum A, Besra GS, Lott JS et al: A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol Microbiol 2007, 65(3):684-699.
31. Campbell DR, Chapman KE, Waldron KJ, Tottey S, Kendall S, Cavallaro G, Andreini C, Hinds J, Stoker NG, Robinson NJ et al: Mycobacterial cells have dual nickel-cobalt sensors: sequence relationships and metal sites of metal-responsive repressors are not congruent. The Journal of biological chemistry 2007, 282(44):32298-32310.
32. Bacon J, Dover LG, Hatch KA, Zhang Y, Gomes JM, Kendall S, Wernisch L, Stoker NG, Butcher PD, Besra GS et al: Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Microbiology 2007, 153(5):1435-1444.

Myself and my laboratory members are keen to take to opportunities to participate in outreach. To date we have participated in the RVC Masterclass sessions, worked with Secondary school and Primary school students to help inspire an interest in Microbiology and  have delivered a session for the family fun day at the Royal Society (Spooky Science October 2017).  Addtionally we have taken part in the Royal SocietySummer Science Exhibition 2019 (It's a knockout).