Dr Neil Marr
BSc (Hons), MRes, PhD
Postdoctoral Research Assistant (Kafarnik)
Department: Clinical Science and Services
Campus: Camden
Research Groups: Brain Health and Behaviour
1: Beaumont RE, Smith EJ, Zhou L, Marr N, Thorpe CT, Guest DJ. Exogenous
interleukin-1 beta stimulation regulates equine tenocyte function and gene
expression in three-dimensional culture which can be rescued by pharmacological
inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling.
Mol Cell Biochem. 2023 Jun 14. doi: 10.1007/s11010-023-04779-z. Epub ahead of
print. PMID: 37314623.
2: Zamboulis DE, Marr N, Lenzi L, Birch HL, Screen HRC, Clegg PD, Thorpe CT. The
Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell
Populations Disproportionately Affected by Aging. Aging Dis. 2023 May 22. doi:
10.14336/AD.2023.0425-1. Epub ahead of print. PMID: 37307816.
3: Marr N, Zamboulis DE, Werling D, Felder AA, Dudhia J, Pitsillides AA, Thorpe
CT. The tendon interfascicular basement membrane provides a vascular niche for
CD146+ cell subpopulations. Front Cell Dev Biol. 2023 Jan 9;10:1094124. doi:
10.3389/fcell.2022.1094124. PMID: 36699014; PMCID: PMC9869387.
4: Caetano-Silva S, Simbi BH, Marr N, Hibbert A, Allen SP, Pitsillides AA.
Restraint upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals
Interaction between Quasi-Static Load and the mTOR Pathway. Int J Mol Sci. 2021
Dec 8;22(24):13220. doi: 10.3390/ijms222413220. PMID: 34948015; PMCID:
PMC8706285.
5: Marr N, Meeson R, Kelly EF, Fang Y, Peffers MJ, Pitsillides AA, Dudhia J,
Thorpe CT. CD146 Delineates an Interfascicular Cell Sub-Population in Tendon
That Is Recruited during Injury through Its Ligand Laminin-α4. Int J Mol Sci.
2021 Sep 8;22(18):9729. doi: 10.3390/ijms22189729. PMID: 34575887; PMCID:
PMC8472220.
6: O'Brien C, Marr N, Thorpe C. Microdamage in the equine superficial digital
flexor tendon. Equine Vet J. 2021 May;53(3):417-430. doi: 10.1111/evj.13331.
Epub 2020 Sep 2. PMID: 32772396.
7: Marr N, Hopkinson M, Hibbert AP, Pitsillides AA, Thorpe CT. Bimodal Whole-
Mount Imaging of Tendon Using Confocal Microscopy and X-ray Micro-Computed
Tomography. Biol Proced Online. 2020 Jul 1;22:13. doi:
10.1186/s12575-020-00126-4. PMID: 32624710; PMCID: PMC7329428.
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CornealCellVision: Derivation of corneal keratocytes from canine induced pluripotent stem cells to develop disease models and novel treatments for corneal disease
This project will generate corneal stromal tissue in the laboratory to pave the way to the development of an artificial cornea for future disease modelling and clinical transplantation into injured and diseased dog eyes to restore vision. . Corneal diseases are one of the most common debilitating source of visual loss that may lead to permanent blindness in humans as well as in animals.