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Extensive hyperpigmentation in a dog with chronic Malassezia
Skin pigmentation depends primarily on the nature and amount
of melanin within epidermal cells.
Pigmentation is often increased in endocrine diseases affecting
the skin or as a consequence of inflammation. Inflammatory
processes may conversely lead to hypopigmentation if melanocytes
are damaged (eg in autoimmune diseases centred on the dermo-epidermal
junction such as lupus erythematosus).