Canine diabetic research

People: Brian Catchpole

At The Royal Veterinary College we have established a national canine diabetes register. This includes a database of clinical information and an archive of residual samples. This diabetic register should allow us to progress our understanding of the causes of this disease.

Correlation of genotype with phenotype: Moving towards individual pharmacogenomic treatment for canine inflammatory bowel disease

People: Atiyeh Peiravan, Karin Allenspach

At the Royal Veterinary College, We are investigating the genetic cause of Inflammatory Bowel Disease (IBD) in German shepherd dogs (GSDs), part of which we will be setting up a new DNA archive of GSD samples. We are looking for blood or saliva samples from GSDs that have been diagnosed with IBD as ‘cases’, and from GSDs without IBD that are over 8 years old as ‘controls’.

Diabetic Remission Clinic

People: Ruth Gostelow, Katarina Hazuchova, Chris Scudder, Stijn Niessen, Yaiza Forcada, David Church

The Diabetic Remission Clinic investigates the optimum management for diabetic cats, and cats in diabetic remission. This includes investigating factors that increase the chance of diabetic remission and prevent cats in remission from relapsing. The clinic is opening a new clinical trial to investigate the benefit of a drug promoting insulin secretion in preventing relapse of diabetes mellitus.

IDEAS (Idiopathic Epilepsy and Anxiety Study) - Investigating the relationship between epilepsy, drug-resistance and affective disorders in the domestic dog

People: Holger Volk, Rowena Packer, Tsz Law, Sarah Hobbs

IDEAS aims to investigate how environment, diet, genetics and other factors affect the development of epilepsy and anxiety, and how they may be linked in dogs with epilepsy. This study will improve our knowledge and ability to diagnose epilepsy and develop treatments for dogs with epilepsy. We aim to increase quality of life for both dogs with epilepsy and their owners. To do this we are specifically recruiting German Shepherd and Border Collies as both breeds are popular in the UK and have a breed predisposition for drug-resistant epilepsy.

Investigating the Effects of Ketogenic Medium-Chain Triglyceride (MCT) Supplement on Canine Epilepsy

People: Benjamin-Andreas Berk, Rowena Packer, Holger Volk

At the Queen Mother Hospital for Animals we are carrying out a study focusing on the dietary effects of Medium-Chain Triglyceride (MCT) oil given as a daily supplement on seizure frequency, severity, and behavioural co-morbidities of dogs diagnosed with idiopathic epilepsy. This study includes, besides complete blood check-up, non-invasive and interactive behavioural tests on cognition, anxiety, and gait. 

The Big Brainy Border Collie Study: Investigating brain structure, function and behaviour In Border Collies with and without Idiopathic Epilepsy

People: Rowena Packer, Holger Volk, Sarah Hobbs

Epilepsy is a complex brain disease seen in both humans and dogs. Subtle differences in brain anatomy, electrical activity in the brain, and day to day behaviour are found between people with epilepsy and people with normal brain development. We are interested in exploring these differences between Border Collies with and without epilepsy, and if they may mimic differences seen in human epilepsy cases.

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