A study to investigate the long-term influence of a medium chain fatty acid diet on canine idiopathic epilepsy - LifeTIME (Long Term remission Mct Epilepsy) study

People: Holger Volk, Elsa Beltran, Joe Fenn, Rowena Packer, Tsz Law

Dietary management for epilepsy is commonly used in humans, and recent studies at RVC have demonstrated that a diet containing medium-chain-triglycerides (MCTs) can reduce seizure frequency, and improve behaviour in some dogs with epilepsy. The purpose of the present trial is to confirm the efficacy of an MCT enriched diet in the management of dogs with idiopathic epilepsy. We will use a parallel design, which means that your dog will either receive a standard high-quality diet or the same diet enriched with MCT.

Canine Diabetes Research

People: Brian Catchpole, Lucy Davison, Marsha Wallace

 At The Royal Veterinary College we have established a national canine diabetes register. This includes a database of clinical information and an archive of residual samples. This diabetic register is used as part of ongoing research into the causes of this disease.

Diabetic Remission Clinic

People: Katarina Hazuchova, Ruth Gostelow, Vanessa Woolhead, Hannah Darcy, David Church

The Diabetic Remission Clinic investigates the optimum management for diabetic cats, and cats in diabetic remission. This includes investigating factors that increase the chance of diabetic remission and prevent cats in remission from relapsing. The clinic is currently running a clinical trial to investigate the benefit of a drug promoting insulin secretion in preventing relapse of diabetes in cats that are already in remission.

IDEAS (Idiopathic Epilepsy and Anxiety Study) - Investigating the relationship between epilepsy, drug-resistance and affective disorders in the domestic dog

People: Holger Volk, Rowena Packer, Tsz Law, Sarah Hobbs

IDEAS aims to investigate how environment, diet, genetics and other factors affect the development of epilepsy and anxiety, and how they may be linked in dogs with epilepsy. This study will improve our knowledge and ability to diagnose epilepsy and develop treatments for dogs with epilepsy. We aim to increase quality of life for both dogs with epilepsy and their owners. To do this we are specifically recruiting German Shepherd and Border Collies as both breeds are popular in the UK and have a breed predisposition for drug-resistant epilepsy.

Investigation of genetic risk factors of diabetes mellitus in European Burmese cats

People: Katarina Hazuchova, Lucy Davison, Brian Catchpole, Ruth Gostelow

Burmese cats have been found to be at increased risk of diabetes mellitus in several geographic regions, including the UK, other European countries and Australia. The aim of our project is to investigate the genetic mutations responsible for the increased susceptibility of Burmese cats to diabetes and to identify any environmental risk factors.

PREDICT Study (Prodrome Recognition in Epileptic Dogs to Improve Control and Therapeutics) – Investigating the potential of non-invasive seizure forecasting in dogs with idiopathic epilepsy

People: Sarah Finnegan, Rowena Packer, Holger Volk, Monica Daley

PREDICT aims to investigate the potential of non-invasive seizure forecasting in dogs with idiopathic epilepsy. This study will improve our knowledge and ability in prediction of seizures and management of canine epilepsy. We aim to increase quality of life for both dogs with epilepsy and their owners. To do this we are specifically recruiting any breed, age and sex of dogs from the United Kingdom.

The Big Brainy Border Collie Study: Investigating brain structure, function and behaviour In Border Collies with and without Idiopathic Epilepsy

People: Rowena Packer, Holger Volk, Sarah Hobbs

Epilepsy is a complex brain disease seen in both humans and dogs. Subtle differences in brain anatomy, electrical activity in the brain, and day to day behaviour are found between people with epilepsy and people with normal brain development. We are interested in exploring these differences between Border Collies with and without epilepsy, and if they may mimic differences seen in human epilepsy cases.

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