Introduction

This is the first in a series of videos which will explore how to control and prevent Bovine Viral Diarrhoea. This video comprises an introduction to the series by the recognised expert in the field Professor Joe Brownlie and past President of the BVA David Catlow.

BVD - Introduction

BVD - The Virus

This film on the BVD Virus is split into three parts. The first part introduces the members of the Pestivirus family. The second part deals with the genomic structure and the individual genes and their products. The third part explains how the different biotypes are formed and the relationship to the diseases caused by the virus.

BVD - The Virus, Part 1

BVD - The Virus, Part 2

BVD - The Virus, Part 3

VETS.TV

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Please note: All videos on this page are for personal and educational use only and may not be used, copied, reproduced, distributed, broadcast, displayed, licensed or otherwise exploited for any other purposes whatsoever without the prior consent of the Royal Veterinary College. Contact Nick Short for further information.

National BVD Control Programme

The following Webinar presentations (recorded in February 2013) are part of the National BVD Control Programme.

This webinar accompanies a series of slides on BVD pathogenesis, diagnosis and control. It is presented as a dialogue between Professor Joe Brownlie and Dr Richard Booth (RVC) and gives some extra background information to each slide that we have accumulated over a number of years working with BVD. The aim of this webinar is to provide teaching material to veterinary students and veterinary surgeons working in the field. There are two parts to the webinar that accompany the single lecture. The set of PowerPoint slides that comprise the lecture will be available through the RDPE initiative for examining the possibility of national BVD control.

BVD Eradication Vets Talk Part 1

BVD Eradication Vets Talk Part 2

BVD Eradication - Farmer and Paraprofession Vet Talk

The following webinar is primarily aimed at farmers and para-professional animal health workers:

Generic PowerPoint Presentations on BVD for download:

The two powerpoint presentations below were put together in 2008.

 BVD – the disease, the veterinarian and the control strategies

 BVD control – How are herds infected?  

IDEXX Webinars

IDEXX Webinars presented by Prof Joe Brownlie and Dr Richard Booth in 2011.

  • BVDV – Diagnostics, Vaccination and Control
  • BVDV – Epidemiology and Biosecurity Risks
  • BVDV – The virus and its pathogenesis

Available from IDEXX Learning Centre > Bovine

RVC 09 - BVD/MD (7.1MB MPEG-4 enhanced podcast)
You have no idea what BVD/MD stands for? Then this podcast is made for you. But Professors Joe Brownlie and Dirk Werling will also be able to give those who have heard about Bovine Viral Diarrhoea and Mucosal Disease before an insight into how their work will transform the strategies to fight this major disease in the livestock sector and how it might even have implications for human medicine.

RVC Podcast logo - cow wearing iPod earphonesYou can also subscribe to the RVC Podcast via the iTunes Store if you have iTunes installed on your computer or see the RVC Podcast page for more information.

BVD Press Articles

"Scotland prepares for new phase of BVD eradication" - Farmers Guardian - 10 Apr 2015 - Farmers Guardian 10 Apr 2015

"Live Vaccine offers hope against BVD" - Farmers Guardian - 27 Mar 2015 - Farmers Guadian 27 Mar 2015

"Do Type 2 viruses pose a risk to bovine viral diarrhoea virus control in the UK?" - Livestock - Vol 20 No 2 March/April 2015 - Prof Joe Brownlie & Dr Richard Booth - Livestock Vol 20 No 2 March/April 2015

"Plan vaccine timings to help protected stock" - Farmers Guardian - 13 February 2015 - Famers Guardian 13 Feb 2015

"Calls for BVD status of all cattle to be declared in Scottish marts" - Farmers Guardian - 6 February 2015 - Farmers Guardian 6 Feb 2015

"Prospects for English BVD control programme" - Farmers Guardian - 14 November 2014 - Farmers Guardian 14 November 2014

"BVD survey highlights confusion" - British Dairying - November 2014 - British Dairying November 2014

"Biosecurity key to effective BVD control" - Farmers Guardian - 10 October 2014 - Farmers Guardian 10 October 2014

"Inconsistent approach to BVD by farmers, survey reveals" - Veterinary Times - 6 October 2014 - James Dessent - Vet Times 6 Oct 2014

"Eliminating virus boosts fertility and growth rates" - Farmers Guardian - 3 October 2014 - Farmers Guardian 3 Oct 2014

"Survey shows need for more advice on BVD" - Farmers Guardian - 26 September 2014 - Farmers Guardian 26 Sept 2014

"BVD must be addressed - no excuses" - British Dairying - September 2014 - Neil Howie - British Dairying - Sept 2014

"Diagnostic tests to detect and eradicate BVDV in herds" - Veterinary Times - 25 August 2014 - Prof Joe Brownlie & Dr Richard Booth - Vet Times 25 Aug 2014

"BVD - Why vaccination alone is not the complete answer to eradication" -Livestock - July/August 2014 - Prof Joe Brownlie - Livestock - July-August 2014

"BVD surveillance scheme launched" - Farmers Guardian - 20 June 2014 - Farmers Guardian 2014 June 20

"Testing times for BVD control" - Farmers Guardian - 20 June 2014 - Farmers Guardian 20 June 2014

"Bovine viral diarrhoea: update on disease and its control" - Veterinary Times - 19 May 2014 - Prof Joe Brownlie & Dr Richard Booth - Vet Times 19 May 2014

"Herd owner experiences of the voluntary phase of a BVD eradication programme" - Veterinary Record - 10 May 2014 - C Devitt, D A Graham, S Coughlan & J O'Flaherty - C Devitt - Vet Record - 10 May 2014

"Critical indicators of BVD" - Farmers Guardian - 9 May 2014 - Farmers Guardian 9 May 2014

"BVD: Not just one type of problem" - Farmers Guardian - 11 April 2014 - Dr Richard Booth - BVD - Not just one type of problem - Farmers Guardian - 11 Apr 14

"Join our Campaign - Together we can wipe out BVD" - Farmers Weekly - 28 March 2014 - Farmers Weekly 28 Mar 2014

"Involving farmers in tackling BVD" - Veterinary Record - 22 March 2014 - Involving farmers in tackling BVD - Vet Rec - 22 Mar 14

"New campaign to help fight BVD" - Farmers Guardian - 7 March 2014 - Farmers Guardian - 7 March 2014

"Join the national control programme to help manage BVD" - DairyCo - Elizabeth Berry - DairyCo - national control programme to help manage BVD

"BVD eradication is achievable" by Aly Balsom - Farmers Guardian - 21 February 2014 - Farmers Guardian 21 Feb 2014

"Why it pays to do something about BVD" by Katie Jones - Farmers Guardian - 15 February 2014 - Farmers Guardian 15 February 2014

"Herd Health Matters - BVD Update" - BCVA Newsletter - February 2014 - BCVA Newsletter - BVD Update - Feb 2014

"Development and review of the voluntary phase of a national BVD eradication programme in Ireland" Paper by Graham, DA, et al - Veterinary Record - 18 January 2014 - Graham D A - Vet Record - 18 Jan 2014

"Plans to make BVD testing compulsory in Northern Ireland" and "BVD control in England" News and Reports on Endemic Diseases, Veterinary Record - 14 December 2013 - Plans to make BVD testing compulsory in NI

"Cattle Review - Bovine Virus Diarrhoea Virus (BVDV)". A review in Livestock UK - November/December 2013, Vol 18 No 6 -written by David C Barrett Cattle Review - BVDV - Livestock UK

"BVA supports latest phase of BVD eradication scheme in Scotland". An article in theVeterinary Record - 23 November 2013 - BVA supports latest phase of BVD eradication scheme in Scotland - Vet Rec 23.11.13

"Leaders discuss National cattle health programme". An article in the Veterinary Times - 18 November 2013 - report by Rebecca Hubbard - Vet Times 18 Nov 2013 - Leaders Discuss National cattle health programme

"England's dairy industry 'behind' on BVD measures". An article in the Veterinary Times - 29 July 2013 - report by Rebecca Hubbard - Vet Times 29 July 2013 England's dairy industry behind on BVD measures

"Linking genetic distribution of BVDV strains in the UK to animal movements". Research Digest in the Veterinary Record - 20 July 2013 - R Booth, C Thomas, L El-Attar, G Gunn & J Brownlie - Booth et al - Vet Re - 20 July 2013

"Eradicating bovine viral diarrhoea virus". Editorial in the Veterinary Record - 22 June 2013 - written by Bryan Charleston - Eradicating bovine viral diarrhoea virus - Vet Rec - Bryan Charleston

"Bovine viral diarrhoea virus: biology, diagnosis and control". Editorial in theVeterinary Record - 27 April 2013 - written by Peter Nettleton - BVDV: biology, diagnosis and control - Vet Rec - P Nettleton

"Controlling BVD". A letter in the Veterinary Record - 6 April 2013 - written by Prof Joe Brownlie Controlling BVD - Vet Record 6 Apr 2013

"Join the national control programme to help manage BVD" produced by the Rural Development Programme for England - BVD Booklet

"English BVD Programme Veterinary Newsletter February 2013" produced by the Rural Development Programme for England - BVD Newsletter - Feb 2013

"Firm handle on BVD eradication". An article from the January 2013 edition of Cow Management, written by Karen WrightCow Management - Jan 2013 - page 1 & Cow Management - Jan 2013 - page 2

"Controlling BVD - call for practioners". A letter in the Veterinary Record - 12 January 2013 - written by Elizabeth Berry, Mary Vickers, Sophie Throup & Jonathan StathamControlling BVD - call for practitioners - Vet Record

"BVD Control Programme for England" - Rural Development Programme for England.BVD control programme for England

"Bovine Virus Diarrhoea (BVD)" Quick Reference Guide produced by the Premium Cattle Health Scheme, SACBVD Quick Reference Guide Page 1 BVD Quick Reference Guide Page 2

"What's your excuse?" An article from the December 2012 edition of Cow Management, written by Rachael PorterCow Management - December 2012

"Prevalence of antibodies to bovine viral diarrhoea virus in bulk tank milk and associated risk factors in Scottish diary herds" - Humphry, R W, Brulisauer, F, McKendrick, I J, Nettleton, P F & Gunn, G J. Veterinary Record - 3 November 2012 -Humphry et al Vet Rec 3 Nov 2012

"New Claim for Bovidec BVD Vaccine" - Novartis Animal Health Novartis Animal Health - New claim for Bovidec BVD Vaccine www.farmanimalhealth.co.uk/cattle-bovidec

"Providing a structured approach to BVD control". An article from the Irish Veterinary Journal, Volume 62, Number 12 - 20 September 2012. AHIJ Vol 62 No 12

"First Annual Report - GB Cattle Health & Welfare Group" - September 2012 -http://www.chawg.org.uk/

The Scottish Government BVD Eradication Programme -http://www.scotland.gov.uk/Topics/farmingrural/Agriculture/animal-welfare/Diseases/disease/bvd

"The BVD experience". An article from the July/August 2012 edition of Cow Managementwritten by Karen WrightCow Management - July/August 2012

"Surveillance in vets' scopes as BCVA convenes for congress". An article fromVeterinary Times - 19 March 2012 - written by A David WeaverVet Times 19 March 2012

"Working together to eradicate BVD in Scotland". An article from the Veterinary Record - 17 March 2012 - written by Sheila VoasWorking together to eradicate BVD in Scotland - Vet Record

"BVD: Where Scotland leads, the rest of the UK should follow". An article from theFarmers Weekly - 8 March 2012 - written by Thomas Tiley.http://www.fwi.co.uk/Articles/08/03/2012/131813/39BVD-Where-Scotland-leads-the-rest-of-the-UK-should.htm

"'UK action on virus 'pathetic'". An article from The Press and Journal - 11 February 2012 - written by Joe WatsonUK action on virus pathetic The Press and Journal

"So Who is Responsible for Disease?". An article from the BCVA Congress Times - 24-26 November 2011, written by Prof Joe BrownlieBCVA Congress Times

"Eradicate BVD with tough testing and biosecurity". An article from the 4th November 2011 edition of Farmers Guardian, written by Prof Joe Brownlie and Jonathan Statham, edited by Katie LomasFarmers Guardian - 4th November 2011

"BVD Control moves on a pace". An article from the October/November 2011 edition ofCow Management written by Karen Wright Cow Management - October/November 2011

"BVD Information Leaflet for Irish Farmers and their Vets" - 4 July 2011 - Animal Health IrelandBVD Information Leaflet for Irish Farmers and their Vets

"Time to 'call time' on BVD". An article from the June 2011 edition of Cow Management,written by Karen WrightCow Management BVD NMR Feature June 2011

"Vaccination alone is simply not enough". An article from the Irish Farmers Journal - 21 November 2009, written by Jack Kennedyhttp://www.farmersjournal.ie/site/farming-Vaccination-alone-is-simply-not-enough-10078.html

"How BVD can wreak havoc in herd if left unchallenged." An article from the October 2008 edition of Dairy Farmer, written by Shirley MacmillanDiary Farmer Oct 2008

"Eradicating BVD: Booklet provides latest information". An article from Farmers Guardian on 18 April 2008. Farmers Guardian - 18 April 2008

BVD Virus Eradication Leaflet, produced in April 2008 by Pfizer Animal Health BVD Virus Eradication Leaflet

"BVD Virus - Eradication from Rutland - What are you doing about it?" A leaflet produced by XL Vets. XL Vets Leaflet

"Friend's expertise aids this vet's understanding of BVD" - article from the 4th February 2008 Veterinary Times by Graham Duncanson Vet Times

"Is it time to tackle BVD?" - article from December 2007 Cow ManagementCow Management Article

"BVD eradication - the first steps in a thousand have been taken" - article from July 2007 Veterinary Review, written by Richard GardVet Review article

"BVD: We must work towards eradication or be left behind - Devising an eradication strategy that works" - joint article from the 8 June 2007 Farmers Guardian, written by Prof Joe Brownlie & Phil SketchleyFarmers Guardian June 07 article

"Producers show willing to help eradicate BVD" - article from 18 May 2007 Farmers WeeklyFarmers Weekly Article

"Beating the scourge of Bovine Viral Diarrhoea Virus" - article from 8 December 2006Farmers Weekly, written by Keith CutlerFarmers Weekly Dec 06 Article

"UK lagging behind on BVD control" - article from the 24 Nov 2006 Farmers Weekly,written by Chrissie LawrenceFarmers Weekly article

"BVDV: breaking the cycle of infection" - comment from The Veterinary Record, 15 July 1995 Vet Record 15 July 1995 001

"BVDV - not yet on the critical list" - article from Farming Business March/April 1994Farming Business Page 1 Farming Business Page 2

"Fighting back" - article from the September 1986 Dairy Farmer, written by John LeitchDairy Farmer - Fighting Back

"Boffins find twin clues to cattle killer disease" - article from 17 August 1984 Farmers Weekly, written by Harry Hope Boffin find twin clues to cattle killer disease - farmers weekly 17-8-84

Papers

Booth, R E, Thomas C J, El-Attar, L M R, Gunn, G & Brownlie, J. (2013). A phylogenetic analysis of Bovine Viral Diarrhoea Virus (BVDV) isolates from six different regions of the UK and links to animal movement dataVet Research 2013, 44:43 Booth et al 2013 Vet Research

Booth, R E, Cranwell, M P & Brownlie, J. (2013). Monitoring the bulk milk antibody response to BVD: the effects of vaccination and herd infection status. Vet Rec 2013 Apr 27;172;449 doi:10.1136/vr.101195 Booth et al 2013 Vet Rec

Iourin, O, Harlos, K, El Omari, K, Lu Weixian, Kadlec, J, Iqbal, M, Meier, C, Palmer, A, Jones, I, Thomas, C, Brownlie, J, Grimes, J M & Stuart D I.  (2013).  Expression, purification and crystallisation of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus Acta Cryst (2013) F69(Pt 1);35-38 Iourin et al 2013

Lanyon, S R, Hill, F I, Reichel, M P & Brownlie, J. (2013) Bovine Viral Diarrhoea: pathogenesis and diagnosisVeterinary Journal 2013http://dx.doi.org/10.1016/j.tvjl.2013.07.024

Booth, R E & Brownlie, J. (2012). Establishing a pilot bovine viral diarrhoea virus eradication scheme in Somerset. Veterinary Record 2012 Jan 21;170(3):73 Booth & Brownlie 2011

Burr, S, Thomas, C, Brownlie, J, Offord, V, Coffey, T J & Werling, D. (2012). Potential evidence for biotype-specific chemokine profile following BVDV infection of bovine macrophagesVet Immunol Immunopathol (2012)http://dx.doi.org/10.1016/j.vetimm.2012.08.009

Gibson, A, Miah, S, Griebel, P, Brownlie, J & Werling, D. (2011). Identification of a lineage negative cell population in bovine peripheral blood with the ability to mount a strong type I interferon response. Developmental and Comparative Immunology36(2012)332-341 Gibson et al 2012

Gibson, A, Larsson, J, Bateman, M, Brownlie, J, & Werling, D. (2011). Bovine Viral Diarrhea Virus Strain- and Cell type-Specific Inhibition of Type I Interferon PathwaysJ VirolApr 2011; 85(7):3695-3697 Gibson et al 2011

Anstaett, O L, Brownlie, J & Collins M E & Thomas, C J.  (2010).  Validation of endogenous reference genes for RT-qPCR normalisation in bovine lymphoid cells (BL3) infected with Bovine Viral Diarrhoea Virus (BVDV).  Vet Immmunology & Immunopathology 137:201-207. 20580438

Makoschey, B, Franken, P, Mars, J M, Dubois, E, Schroeder, C, Thiry, J, Alvarez, M, Rypula, K, Cavirani, S, Arnaiz, I, Houtain, J Y, Bartak, P, Brownlie, J, Wolf, G, Meyer, G, Klees, W, Beer, M, Moennig, V & Thiry, E. (2010). IBR and BVD control: the key to successful herd management. Berl Munch Tierarztl Wochenschr 2010 Nov-Dec;123(11-12):519-21, 516-8. 2010 IBR and BVD control - the key to successful herd management

Collins, M E, Heaney, J, Thomas, C J & Brownlie, J. (2009) Infectivity of Pestivirus following persistence of acute infection. Vet Micro 138:289-296. Collins_2009_ Vet Micro

Thomas, C, Young, N J, Heaney, J, Collins, M E & Brownlie, J. (2009). Evaluation of efficacy of mammalian and baculovirus expressed E2 subunit vaccines candidates to bovine viral diarrhoea virus. Vaccine 27:2387-2393. Thomas_2009_Vaccine

Lindberg, A, Brownlie, J, Gunn, G J, Houe, H, Moennig, V, Saatkamp, H W, Sandvik, T, Valle, P S.  (2006).  The control of bovine diarrhoea virus in Europe:  today and in the future.  Rev Sci tech Offic Int Epiz25:961-979. Lindberg_Rev Sci tech_2006

Young, N J, Thomas, C J, Collins, M E & Brownlie, J.  (2006).  Real-time RT-PCR detection of Bovine Viral Diarrhoea Virus in whole blood using an external RNA reference. Journal of Virological Methods 138: 218-222 Young_2006_Journal-of-Virological-Methods

Werling, D, Rurik, A, Heaney, J, Moeller, E & Brownlie, J.  (2005).  Ability to differentiate between cp and ncp BVDV by microarrays:  Towards an application in clinical veterinary medicine.  Veterinary Immunology & Immunopathology Oct 18;  108:157-164Werling_2005_Veterinary-Immunology-and-Immunopathology

Young, N J, Thomas, C J, Thompson, I, Collins, M E & Brownlie, J.  (2005).  Immune responses to non-structural protein 3 (NS3 of bovine viral diarrhoea virus (BVDV) in NS3 DNA vaccinated and naturally infected cattle.  Preventative Veterinary MedicineNov 15; 72:115-120. Young_2005_Preventive-Veterinary-Medicine_1

Stokstad, M., Collins M. E., Brownlie, J. (2004) Analysis of variation of bovine viral diarrhoea virus E2 sequence following transplacental infection of cattle. Vet Microbiol Sep 8; 102(3-4):141-145 Stokstad_2004_Veterinary-Microbiology

Nobiron, I, Thompson, I, Brownlie J & Collins, ME.  (2003).  DNA vaccination against bovine viral diarrhoea virus induces humoral and cellular responses in cattle with evidence for protection against viral challenge.  Vaccine, 2003 May 16; 21(17-18):2091-2101. Nobiron_2003_Vaccine

Stokstad, M., Collins M. E., Sorby R., Barboni, P, Meyers, G, Løken T. and Brownlie, J. (2003)The role of a defective interfering particle DI9c in mucosal disease in cattleArch Virol Mar 2004; 149(3):571-82 Arch of Viro 2004

Nobiron, I, Thompson, I, Brownlie, J & Collins, M E.  (2001).  Cytokine adjuvancy of BVDV DNA vaccine enhances both humoral and cellular immune responses in miceVaccine 19:4226-4235

Brownlie, J, Thompson, I & Curwen, A. (2000).  Bovine virus diarrhoea virus – strategic decisions for diagnosis and control.  In Practice 22:176-187. In Practice Article

Nobiron, I, Thompson, I, Brownlie, J & Collins, M E.  (2000).  Co-administration of IL-2 enhances antigen-specific immue responses following vaccination with DNA encoding the glycoprotein E2 of bovine viral diarrhoea virus.  Veterinary Microbiology 76:129-142. Nobiron_2000_Veterinary-Microbiology

Booth, P J, Collins, M E, Jenner, L, Prentice, H, Ross, J, Badsberg, J H, & Brownlie J.  (1999). Association of non-cytopathogenic BVDV with bovine blastocysts:  effects of washing, duration of viral exposure and degree of blastocyst expansion. Veterinary Record 144:150-152 Vet Rec 1999

Collins, M E, Desport, M & Brownlie, J.  (1999).  Bovine viral diarrhea virus quasispecies during persistent infection.  Virology 259:85-98. Collins_1999_Virology

Booth, P J, Collins, M E, Jenner, L, Prentice, H, Ross, J, Badsberg, J H & Brownlie, J.  (1998). Noncytopathogenic bovine viral diarrhea virus (BVDV) reduces cleavage but increases blastocyst yield of in vitro produced embryos.  Theriogenology 50: 769-777. Booth_1998_Theriogenology

Brownlie, J, Hooper, L B, Thompson, I & Collins, M E.  (1998).  Maternal recognition of foetal infection with bovine virus diarrhoea virus (BVDV) - the bovine pestivirus.Clinical and Diagnostic Virology 10:141-150 Brownlie 1998 Clin Diag Viro

Desport, M, Collins, M E & Brownlie, J. (1998). Genome instability in BVDV: an examination of the sequence and structural influences on RNA recombination.Virology 246:352-361. Desport_1998_Virology

Brownlie, J, Booth, P J, Stevens, D A & Collins, M E. (1997).  Expression of non-cytopathogenic bovine viral diarrhoea virus (BVDV) in oocytes and follicles of persistently infected cattle. Veterinary Record 141:335-337  (plus colour illustrationsVeterinary Record 141:425) Brownlie 1997 Vet Rec

Innocent, G, Morrison, I, Brownlie, J & Gettinby G.  (1997).  A computer simulation of the transmission of immunity and survival of persistently infected animals on the spread of bovine viral diarrhoea virus in dairy cattle.  Epidemiol Infect 119(1):91-100Epi Infect 1997

Innocent, G, Morrison, I, Brownlie, J & Gettinby G.  (1997).  The use of a mass-action model to validate the output from a stochastic simulation model of bovine viral diarrhoea virus spread in a closed dairy herd.  Prev Vet Med 31(3-4):199-209.Innocent_1997_Preventive-Veterinary-Medicine

Booth, P J, Stevens, D A, Collins, M E & Brownlie, J. (1995).  Detection of bovine viral diarrhoea virus (BVDV) antigen and RNA in oviduct and granulosa cells of persistently infected cattle.  J Reprod Fert 105:17-24 J Repro Fert 1995

Brownlie, J & Clarke, M C. (1995).  Bovine virus diarrhoea virus (BVDV) biotype distribution in the progress of intestinal lesions. Bull Soc Franco-Japonaise Sci Vet6: 77-81 Brownlie 1995 Bull Soc Franco

Brownlie, J, Clarke, M C, Hooper, L B & Bell, G D.  (1995).  Protection of the bovine foetus from bovine virus diarrhoea virus by use of a new inactivated vaccine (Torvac-BVD). Vet Record 137:58-62 Brownlie 1995 Vet Rec

Brownlie, J.  (1994).  The management and control of bovine virus diarrhoea virus in cattle herds. Cattle Practice 4:24-36 Brownlie 1994 Cattle Prac

Desport, M, Collins, M E & Brownlie, J. (1994).  Detection of Bovine Viral Diarrhoea Virus RNA by in situ hybridisation with Digoxigenin-Labelled Riboprobes. Intevirology37:269-276 Desport 1994 Intervirology

Howard, C J, Clarke, M C, Sopp, P & Brownlie, J. (1994).  Systemic vaccination with inactivated bovine virus diarrhoea virus protects against respiratory challengeVet. Micro 42:171-179. Howard_1994_Veterinary-Microbiology

Sopp, P, Hooper, L B, Clarke, M C, Howard, C J and Brownlie, J. (1994).  Detection of Bovine Viral Diarrhoea Virus p80 protein in subpopulations of bovine leucocytes.  Journal of General Virology 75:1189-1194. Sopp_Journal of Gen Viro_1994

Hibberd, R C, Turkington, A & Brownlie, J.  (1993).  Fatal bovine viral diarrhoea virus infection of adult cattle.  Vet Rec 132(9):227 Hibberd 1993 Vet Rec

Howard, C J, Clarke, M C, Sopp, P & Brownlie, J. (1992).  Immunity to bovine virus diarrhoea virus in calves: the role of different T-cell subpopulations analysed by specific depletion in vivo with monoclonal antibodies.  Vet Immunol Immunopath  32: 303-314 Howard 1992 Vet Imm

Brownlie, J. (1991). The pathways for bovine virus diarrhoea virus biotypes in the pathogenesis of diseaseArch Virol  3:79-96 Brownlie 1991 Arch Virol

Brownlie, J. (1990).  Pathogenesis of mucosal disease and molecular aspects of bovine virus diarrhoea virus.  Veterinary Microbiology 23:371-382 Brownlie 1990 Vet Micro

Brownlie, J. (1990).  The pathogenesis of bovine virus diarrhoea virus infections. Rev Sci Tech Off Int Epiz9:43-59 Brownlie 1990 Rev Sci Tec

Brownlie, J & Clarke, M C. (1990).  Bovine virus diarrhoea virus: speculation and observations on current concepts.  Rev Sci Tech Off Int Epiz, 7:223-230 Brownlie 1990 Rev Sci Tech Off int Epiz

Desport, M & Brownlie J. (1990).  Molecular characterisation of the coding region for p.125 for homologous BVDV biotypes.  Arch Virol S3:261-266 Desport 1991 Arch Virol

Mignon, B, Schwers, A, Waxweiler, S, Boulanger, D, Dubuisson, J, Brownlie, J & Pastoret, P P. (1990).  Etude de la stabilite antigenique d’une souche non cytopathogene de virus BVD chez des animaux infectes experimentalement de maniere persistante.  Ann Med Vet 134:325-329 Mignon 1990 Ann Med Vet

Brownlie, J, Clarke, M C & Howard, C J. (1989).  Enfermedad de las mucosas-estudios secuenciales sobre la infectividad del virus de la diarrea virica bovina (BVD) sobre el tejido linfatico intestinal.  Med. Vet., 6:3-8 Brownlie 1989 Med Vet

Brownlie, J, Clarke, M C & Howard, C J. (1989).  Experimental infection of cattle in early pregnancy with a cytopathic strain of bovine virus diarrhoea virus.  Research in Veterinary Science 116:307-311 Brownlie 1989 Res Vet Sci

Brownlie, J, Clarke, M C & Howard, C J. (1989). The failure of the cytopathogenic biotype of bovine virus diarrhoea virus to induce tolerance. Immunobiology 4:151Brownlie 1989 Immunobio

Clarke, M C, BrownlieJ, & Howard, C J. (1989). The effect of immunosuppression with corticosteroid on the infection of calves with bovine virus diarrhoea. Immunobiology 4:152 Clarke 1989 Immuno

Howard, C J, Clarke, M C, Brownlie J & Sopp, P. (1989). Effect of in vivo depletion of BoT4+ and BoT8+ lymphocytes with monoclonal antibodies on infection with bovine virus diarrhoea virus in calvesImmunobiology 4:154 Howard 1989 Immunobio

Howard, C J, Clarke, M C & Brownlie, J. (1989).  Protection against respiratory infection with bovine virus diarrhoea virus by passively acquired antibody. Veterinary Microbiology 19:195-203 Vet Micro Paper

Brownlie, J. (1988). Mucosal disease - A pestilence of cattle.  Journal of Royal Agricultural Society, England 150:145-152 Brownlie 1988 RASE

Brownlie, J, Clarke M C, Howard, C J & Pocock, D H.  (1987).  Pathogenesis and epidemiology of Bovine Virus Diarrhoea Virus Infection of cattle.  Ann Rech Vet18:157-166 Brownlie 1987 Ann Rech Vet

Howard, C J, Brownlie, J & Clarke, M C. (1987).  Comparison by the neutralisation assay of pairs of non-cytopathogenic and cytopathogenic strains of bovine virus diarrhoea virus isolated from cases of mucosal disease.  Veterinary Microbiology13: 361-369 Howard et al Vet Micro

Pocock, D H, Howard, C J, Clarke, M C & Brownlie, J. (1987).  Variation in the intracellular polypeptide profiles from different isolates of bovine virus diarrhoea virusArchives of Virology 94:43-53 Pocock 1987 Arch Virol

Howard, C J, Brownlie, J & Thomas, L H. (1986).  Prevalence of bovine virus diarrhoea virus viraemia in cattle in the UK.  Veterinary Record 119:628-629 Howard 1986 Vet Rec

Brownlie, J. (1985).  Clinical aspects of the bovine virus diarrhoea/mucosal disease complex in cattle.  In Practice 7:195-202 Brownlie 1985 In Practice

Brownlie, J. (1985).  BVD - understanding the nature of infection.  Proc. British Cattle Veterinary Association 109-111 Brownlie 1985 BCVA

Howard, C J, Clarke, M C & Brownlie, J. (1985).  An enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to bovine viral diarrhoea virus (BVDV) in cattle sera.  Veterinary Microbiology 10: 359-369 Howard 1985 Vet Micro

Brownlie, J, Nuttall, PA, Stott, E J, Taylor, G & Thomas, L H.  (1980).  Experimental infection of calves with two strains of bovine virus diarrhoea virus: certain immunological reactions.  Veterinary Immunology and Immunopathology 1: 371-378 Brownlie 1980 Vet Imm & Immunopath 

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