The Royal Veterinary College's Immune Regulation and Cancer group seeks to understand regulatory mechanisms that maintain immune tolerance, and how failure of these mechanisms lead to autoimmune, inflammatory and neoplastic disease.
RVC researchers collaborate with clinical scientists, pathologists, and developmental biologists and benefit from having access to veterinary data.
A key focus is regulatory T cell (Treg) biology, including studies addressing control of their development and function in mice and dogs. More clinically applied research is characterising the role of Tregs in equine sepsis and equine placental development and in immunoscenescence and its impact on vaccination in elderly dogs. The group is also interested in genetic polymorphisms and auto-antigens that characterise canine Type 1 diabetes as a model for latent onset diabetes of the adult
Our applied immunologists are concerned with innate immunity. They work with clinical clinical scientists to investigate the pathophysiology of disease. Canine inflammatory bowel disease (IBD) is an example of a disease where failure of mucosal tolerance occurs as a esult of the dysfunction of pathogen recognition receptors.
Healthy ageing and regulation of cellular quality (autophagy) are biological processes which, when they start to go wrong, are likely to cause growth issues, leading to cancers. At the RVC, cell and developmental biologists work with clinical scientists and pathologists at veterinary and medical schools, to study cancers in veterinary patients as models for human cancer.
This 'One Health' approach is supported by our clinical oncology service at the Queen Mother Hospital for Animals and an archive of tissues and samples is maintained by the College's Clinical Investigation Centre.
People in this Research Group
Veterinary Epidemiology, Economics and Public Health, Hawkshead