Department: Comparative Biomedical Sciences

Campus: Hawkshead

Peter is an Emeritus Professor in Pharmacology. He is currently serving on the Research Assessment Exercise Committee which reviews University research performances nationally.

Peter graduated from the Chelsea School of Pharmacy, University of London with a Bachelors in Pharmacy in 1961. He began his PhD straight after, moved to the RVC in 1962 and took up the post of Research Student. In 1964 he attained the post of Assistant Lecturer; over the following years he became a Lecturer, Reader, Professor, Head of the Veterinary Basic Sciences Department from 1992-1997, Vice-Principal for teaching and Deputy Principal from 1997-2002 and Professor of Veterinary Pharmacology.

Peter’s main research interests lie around the mechanisms and mediators of acute inflammation in species of veterinary interest. He is also involved in studies of the pharmacodynamics (PDs) and pharmacokinetics (PKs) of anti-inflammatory drugs (particularly non-steroidal anti-inflammatory drugs - NSAIDs) and antimicrobial drugs. Current projects include: (1) PD-PK modelling of NSAIDs in models of acute inflammation in the cat, (2) PD-PK modelling of antimicrobial drugs in a model of acute inflammation in the calf and (3) PD-PK modelling of antimicrobial drugs in calf pneumonia. He is currently collaborating with Dr Ali Abadi (Iran), Prof Landoni (Argentina) and Prof Toutain (France).
 

LEES, P; PELLIGAND, L; ELLIOTT, J; TOUTAIN, PL; MICHELS, G; STEGEMANN (2015)
Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38;1:1-14. PubMed ID 25413929

SIDHU, P. K., LANDONI, M. F. & LEES, P. (2006) Pharmacokinetic and pharmacodynamic interactions of tolfenamic acid and marbofloxacin in goats. Res Vet Sci 80, 79-90. PubMed ID 16005916

SIDHU, P. K., LANDONI, M. F. & LEES, P. (2005) Influence of marbofloxacin on the pharmacokinetics and pharmacodynamics of tolfenamic acid in calves. J Vet Pharmacol Ther 28, 109-119. PubMed ID 15720523

SIDHU, P. K., LANDONI, M. F. & LEES, P. (2005) Influence of marbofloxacin on the pharmacokinetics and pharmacodynamics of tolfenamic acid in calves. J Vet Pharmacol Ther 28, 109-119. PubMed ID 15720523

GIRAUDEL, J. M., TOUTAIN, P. L. & LEES, P. (2005) Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. Am J Vet Res 66, 700-709. PubMed ID 15900953

GIRAUDEL, J. M., TOUTAIN, P. L. & LEES, P. (2005) Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. Am J Vet Res 66, 700-709. PubMed ID 15900953

GIRAUDEL, J. M., DIQUELOU, A., LEES, P. & TOUTAIN, P. L. (2005) Development and validation of a new model of inflammation in the cat and selection of surrogate endpoints for testing anti-inflammatory drugs. J Vet Pharmacol Ther 28, 275-285. PubMed ID 15953201

GIRAUDEL, J. M., DIQUELOU, A., LEES, P. & TOUTAIN, P. L. (2005) Development and validation of a new model of inflammation in the cat and selection of surrogate endpoints for testing anti-inflammatory drugs. J Vet Pharmacol Ther 28, 275-285. PubMed ID 15953201

GIRAUDEL, J. M., DIQUELOU, A., LAROUTE, V., LEES, P. & TOUTAIN, P. L. (2005) Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the cat. Br J Pharmacol 146, 642-653. PubMed ID 16113689

GIRAUDEL, J. M., DIQUELOU, A., LAROUTE, V., LEES, P. & TOUTAIN, P. L. (2005) Pharmacokinetic/pharmacodynamic modelling of NSAIDs in a model of reversible inflammation in the cat. Br J Pharmacol 146, 642-653. PubMed ID 16113689

DUNNETT, M., RICHARDSON, D. W. & LEES, P. (2004) Detection of enrofloxacin and its metabolite ciprofloxacin in equine hair. Res Vet Sci 77, 143-151. PubMed ID 15196904

DUNNETT, M. & LEES, P. (2004) Hair analysis as a novel investigative tool for the detection of historical drug use/misuse in the horse: a pilot study. Equine Vet J 36, 113-117. PubMed ID 15038432

SIDHU, P., SHOJAEE ALIABADI, F., ANDREWS, M. & LEES, P. (2003) Tissue chamber model of acute inflammation in farm animal species. Res Vet Sci 74, 67-77. PubMed ID 12507568

SHOJAEE ALIABADI, F. & LEES, P. (2003) Pharmacokinetic-pharmacodynamic integration of danofloxacin in the calf. Res Vet Sci 74, 247-259. PubMed ID 12726744

RICKARDS, K. J., PAGE, C. P., LEES, P., GETTINBY, G. & CUNNINGHAM, F. M. (2003) In vitro and ex vivo effects of the phosphodiesterase 4 inhibitor, rolipram, on thromboxane production in equine blood. J Vet Pharmacol Ther 26, 123-130. PubMed ID 12667182

LEES, P., TAYLOR, P. M., LANDONI, F. M., ARIFAH, A. K. & WATERS, C. (2003) Ketoprofen in the cat: pharmacodynamics and chiral pharmacokinetics. Vet J 165, 21-35. PubMed ID 12618066

DEAN, M. F., LEE, Y. W., DASTJERDI, A. M. & LEES, P. (2003) The effect of link peptide on proteoglycan synthesis in equine articular cartilage. Biochim Biophys Acta 1622, 161-168. PubMed ID 12928112

ARIFAH, A. K., LANDONI, M. F. & LEES, P. (2003) Pharmacodynamics, chiral pharmacokinetics and PK-PD modelling of ketoprofen in the goat. J Vet Pharmacol Ther 26, 139-150. PubMed ID 12667184

ALIABADI, F. S., LANDONI, M. F. & LEES, P. (2003) Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids. Antimicrob Agents Chemother 47, 626-635. PubMed ID 12543670

ALIABADI, F. S., ALI, B. H., LANDONI, M. F. & LEES, P. (2003) Pharmacokinetics and PK-PD modelling of danofloxacin in camel serum and tissue cage fluids. Vet J 165, 104-118. PubMed ID 12573598

SARASOLA, P., LEES, P., ALIABADI, F. S., MCKELLAR, Q. A., DONACHIE, W., MARR, K. A., SUNDERLAND, S. J. & ROWAN, T. G. (2002) Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica. Antimicrob Agents Chemother 46, 3013-3019. PubMed ID 12183261

MARR, K. A., LEES, P. & CUNNINGHAM, F. M. (2002) Antigen challenge increases adherence of circulating neutrophils in horses with chronic obstructive pulmonary disease. Equine Vet J 34, 65-70. PubMed ID 11817553

LIPSCOMB, V. J., ALIABADI, F. S., LEES, P., PEAD, M. J. & MUIR, P. (2002) Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis. Vet Rec 150, 684-689. PubMed ID 12074237

LEES, P. & LANDONI, M. F. (2002) Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse. J Vet Pharmacol Ther 25, 433-448. PubMed ID 12485349

FREAN, S. P., CAMBRIDGE, H. & LEES, P. (2002) Effects of anti-arthritic drugs on proteoglycan synthesis by equine cartilage. J Vet Pharmacol Ther 25, 289-298. PubMed ID 12213118

DUNNETT, M., LITTLEFORD, A. & LEES, P. (2002) Phenobarbitone concentrations in the hair, saliva and plasma of eight epileptic dogs. Vet Rec 150, 718-724. PubMed ID 12081307

ARMSTRONG, S. & LEES, P. (2002) Effects of carprofen (R and S enantiomers and racemate) on the production of IL-1, IL-6 and TNF-alpha by equine chondrocytes and synoviocytes. J Vet Pharmacol Ther 25, 145-153. PubMed ID 12000535

ARIFAH, A. K. & LEES, P. (2002) Pharmacodynamics and pharmacokinetics of phenylbutazone in calves. J Vet Pharmacol Ther 25, 299-309. PubMed ID 12213119

ALIABADI, F. S. & LEES, P. (2002) Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin in calf serum, exudate and transudate. J Vet Pharmacol Ther 25, 161-174. PubMed ID 12081611

RICKARDS, K. J., PAGE, C. P., LEES, P. & CUNNINGHAM, F. M. (2001) Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors. J Vet Pharmacol Ther 24, 275-281. PubMed ID 11555183

ARIFAH, A. K., LANDONI, M. F., FREAN, S. P. & LEES, P. (2001) Pharmacodynamics and pharmacokinetics of ketoprofen enantiomers in sheep. Am J Vet Res 62, 77-86. PubMed ID 11197566

ALIABADI, F. S. & LEES, P. (2001) Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration. Am J Vet Res 62, 1979-1989. PubMed ID 11763192

Peter has only recently finished teaching on the BVetMed course, for which he taught on for 40 years. His areas of interest were the kidney, fluid balance, the Autonomic and Central nervous systems, cardiovascular and respiratory systems, Inflammation, anti-inflammatory and antimicrobial drug pharmacology. He now mainly teaches PhD students

All of Peter’s research has been geared towards improving clinical Veterinary Medicine. He has strived to optimise dosage in order to minimise toxic effects, maximise effectiveness and reduce build-up of resistance.

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