Department: Comparative Biomedical Sciences

Campus: Camden

Research Groups: Brain Health and Behaviour

In 2012, I completed my PhD studies at Royal Holloway University London where I developed a novel biomedical model to aid our understanding of the underlying pathologies in Alzheimer’s disease. For my postdoctoral studies, I moved to the Institute of Neurology UCL where I investigated mitochondrial pathologies associated with neurodegenerative diseases such as Parkinson’s disease and ALS. In 2017, I was appointed a research fellowship at the RVC where my research investigates mitochondrial calcium in Leigh’s syndrome. This was followed by being awarded a research fellowship from Alzheimer's Research UK in 2018 which allows me to investigate mitochondrial calcium dynamics in Alzheimer's disease.

In 2018, I was awarded the Young Bioenergeticist Award from the Biophysical Society: https://www.rvc.ac.uk/research/news/general/young-bioenergeticist-award

I am also a commitee member of the Biochemical Society's Energy and Metabolism board: http://www.biochemistry.org/Events/ThemePanels/ResearchAreaIIIEnergyandMetabolism.aspx

My research assesses mitochondrial calcium handling in neurodegenerative diseases using innovative technologies and disease models to understand how physiology becomes pathology and how this can ultimately be prevented. Here, I am using fluorescent live cell imaging technologies to assess calcium dynamics and how those are linked to overall mitochondrial health and ATP levels in physiology and pathology. This work employs predominantly stem cell derived neurons from either patients bearing disease-associated mutations or healthy controls.

My research is supported by a RVC fellowship, Alzheimer's Research UK Research Fellowship and a Royal Society Research Grant.

Soutar, M P M, Kempthorne, L, Annuario, E, Luft, C, Wray, S, Ketteler, R, Ludtmann M H R, Plun-Favreau, H. (2018) FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy. Autophagy, 2019

Ludtmann, M H R, Kostic, M, Horne, A, Gandhi, S, Sekler, I, Abramov, A Y. LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation. (2019) CELL DEATH & DISEASE, 10265

Ludtmann M H R, Angelova, P R, Horrocks, M H, Choi, M L, Rodrigues, M, Baev, A Y, Berezhnov, A V, Yao, Z, Little, D, Banushi, B, Al-Menhali, A S, Ranasinghe, R T, Whiten, D R, Yapom, R, Dolt, K S, Devine, M J, Gissen, P, Kunath, T, Jaganjac, M, Pavlov, E V, Klenerman, D, Abramov, A Y, Gandhi, S. (2018) α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease. Nature Communications, 92293.  

Ludtmann M.H.R. and Abramov A.Y. (2018) Mitochondrial calcium imbalance in Parkinson's disease. Neuroscience Letters, S0304-3940 (17)

Manole A., Jaunmuktane Z., Hargreaves I., Ludtmann M.H.R., Pandraud A., Salpietro V., Pope S., Horga A., Scalco R.S., Li A., Ashokkumar B., Lourenço C.M., Horvath R., Chinnery P.F., Toro C., Singleton A.B., Abramov A, Muntoni F., Hanna F.G., Reilly M.M., Revesz T., Kullmann D.M., Jepson J.E.C. and Houlden H. (2017) Mitochondrial impairment in a treatable childhood neuropathy. Brain, 140, (11): 2820–2837

Iljina M., Hong L., Horrocks M.H., Ludtmann M.H., Choi M.L, Hughes C.D., Ruggeri F.S, Guilliams T., Buell A.K, Gandhi S., Bryant C.E., Vendruscolo M., Knowles T.P.J., Dobson C.M., De Genst E., Klenerman D. (2017) Nanobodies raised against monomeric α-synuclein inhibit fibril-formation and destabilize toxic oligomeric species of α-synuclein. BMC Biology, 15, 57

Ludtmann M.H.R., Arber C., Bartolome F., de Vicente M., Preza E., Carro E., Houlden H., Gandhi S., Wray S. and Abramov AY (2017) Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons. JBC, 292(21): 8907–8917.

Ludtmann M.H.R., Angelova, P.R., Ninkina, N., Gandhi S., Buchman V.L, Abramov A.Y. (2016) Monomeric alphasynuclein exerts a physiological role in brain ATP synthase. Journal of Neuroscience, 36 (41): 10510-10521  Ludtmann M.H.R. and Abramov A.Y. (2016) Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders, 2nd edition pp.241-253

Angelova P.R., Ludtmann M.H., Horrocks M.H., Negoda A., Cremades N., Klenerman D., Dobson C.M., Wood N.W., Pavlov E.V., Gandhi S., Abramov A.Y. (2016) Ca2+ is a key factor in α-synuclein-induced neurotoxicity. Journal of Cell Science, 129, (9):1792-801.

Deas E., Cremades N., Angelova P.R., Ludtmann M.H., Yao Z., Chen S., Horrocks M.H., Banushi B., Little D., Devine M.J., Gissen P., Klenerman D., Dobson C.M., Wood N.W., Gandhi S., Abramov A.Y. (2016) Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. Antioxidant and Redox Signaling, 1, (7):376-91

Ludtmann M.H., Kostic M., Bading H., Hershfinkel M., Steer E., Chu C.T., Abramov A.Y., Sekler I. (2015) PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons. Cell Reports, 13, (2):376-86.

Reeve A.K., Ludtmann M.H., Angelova P.R., Simcox E.M., Horrocks M.H., Klenerman D., Gandhi S., Turnbull D.M., Abramov A.Y. (2015) Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death and Disease, 6, e1820

Mencacci N.E., Rubio-Agusti I., Zdebik A., Asmus F., Ludtmann M.H.R. et al. (2015) A Missense Mutation in KCTD17 Causes Autosomal Dominant Myoclonus-Dystonia. American Journal of Human Genetics, 96, (6); 938–947

Neary M.T., Ng K.E., Ludtmann M.H., Hall A.R., Piotrowska I., Ong S.B., Hausenloy D.J., Mohun T.J., Abramov A.Y., Breckenridge R.A. (2014) Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function. Journal of Molecular and Cellular Cardiology, 74; 340-352

Ludtmann M.H.R., Otto G.P., Schilde C., Chen Z.-H., Allan C.Y., Brace S., Beesley P.W., Kimmel A.R, Fisher P., Killick R., Williams R.S.B. (2014). An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. Journal of Cell Science, April 1, 127; 1576-84

Ludtmann M.H.R., Angelova P.R., Zhang Y., Abramov A.Y., Dinkova-Kostova A.T. (2014) Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation. Biochemical Journal, 457, (3):415-24 

Waheed A, Ludtmann M.H., Pakes N, Robery S, Kuspa A, Dinh C, Baines D, Williams RS, Carew MA. (2014) Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner. British Journal of Pharmacology, 171; 2659-70

Siddall H.K., Yellon D.M., Ong, S.B, Mukherjee U.A., Burke N., Hall A.R., Angelova P.R., Ludtmann M.H.R., Deas E., Davidson S.M., Mocanu M.M., Hausenloy D.J. (2013). Loss of PINK1 Increases the Heart's Vulnerability to IschemiaReperfusion Injury. PloS One, 8, (6)

Ludtmann M.H.R., Boeckeler, K. and Williams, R.S.B. (2011) Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder. Seminars in Cell & Developmental Biology, 22, (1) 105-113

Ludtmann M.H., Rollinson D., Emery A.M., and Walker A.J. (2009) Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, Schistosoma mansoni. International Journal of Parasitology, 39, (11) 1223-1233

 

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