Department: Comparative Biomedical Sciences

Campus: Camden

Dr Marta Farré Belmonte has been a postdoctoral research associate working with Dr. Larkin for the last 3 years. During this time she has acquired expertise in comparative genomics and bioinformatics, and became involved in three large international projects focusing on chromosomal rearrangements in the blind mole rat, avian genomics and ruminant genome evolution. She gained an international recognition confirmed by her authorship on the chapter ‘Cytogenetics and chromosome maps’ in the famous A. Ruvinsky’s ‘The genetics of cattle’ book. She was an invited speaker at the major meeting on contemporary evolutionary genomics (Genome 10K meeting, 2015), a keynote speaker in the International Chromosome Conference at Canterbury (2015), and an invited speaker in the major meeting on animal genome research (Plant & Animal Genome meeting PAG, 2016).

Her PhD project, held at Universitat Autònoma de Barcelona, under the supervision of Dr. Ruiz-Herrera, focused on the evolutionary mechanisms of mammalian genome reshuffling, for which Marta used both molecular cytogenetics and bioinformatics approaches. She reconstructed the structure of ancestral mammalian karyotypes and identified the evolutionary forces affecting the evolution of karyotypes. Moreover, she revealed the links between recombination and speciation in primate evolution. She won a one-year project studying the 3D configuration of the nuclei in Hominidae family from the Barcelona Zoo.

*Joint first authors.

  1. KimJ.*, Farré M.*, Auvril L., Capitanu B., Larkin D.M., Ma J’, Lewin H.A. The reconstruction and evolutionary history of eutherian chromosomes. PNAS. 2017 July 114:27.
  2. Damas J., O’Connor R., Farré M., et al. Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set. Genome Res. 2016 Nov 30.
  3. Farré M., Narayan J., Slavov G.T., Auvil L., Li C., Jarvis E.D., Burt D.W., Griffin D.K., Larkin D.M. Novel insights into chromosome evolution in birds, archosaurs, and reptiles. Genome Biol Evol. 2016 Aug 25: 2442-51.
  4. Bryan C., Guterman G., Ma KL., Lewin HA., Larkin DM., Kim J., Ma J., Farré M. Synteny Explorer: An interactive visualization application for teaching genome evolution. IEEE Trans Vis Comput Graph. 2016 Aug 5.
  5. Beynon S., Slavov G.T., Farré M., Sunduimijid B., Waddams K., Davies B., Haresign W., Kijas J., MacLeod I.M., Newbold J., Davies L., Larkin D.M. Population structure and history of the Welsh sheep breeds determined by whole genome genotyping. BMC Genetics 2015 Jun20;16(1):65.
  6. Schimd M., Smith J., Burt DW., … FarréM., Fasold M. et al. Third report on chicken genes and chromosomes 2015. Cytogenet Genome Res. 2015; 145:78-179.
  7. Farré M., Robinson T.J., Ruiz-Herrera A. An integrative breakage model of genome architecture, reshuffling and evolution. BioEssays 2015 Mar 4 [Epub ahead]
  8. Zhang G., Li C., Li Q., Li B., Larkin D.M., ...Farré M., Narayan J., et al. Comparative genomics across modern bird species reveal insights into pan-avian genome evolution and trait biodiversity. Science 2014 Dec 12:1311-20.
  9. Romanov M.N.*, Farré M.*, Lithgow P.E., Fowler K.E., Skinner B.M., O’Connor R., Fonseka G., Backström N., Matsuda Y., Nishida C., Houde P., Jarvis E.D., Ellegren H., Burt D.W., Larkin D.M. and Griffin D.K. Reconstruction of the avian genome organization and evolution from a chromosomal perspective suggests that the chicken lineage most closely resembles the dinosaur avian ancestor. BMC Genomics 2014 Dec 11:1060.
  10. Fang X., Nevo E., Han L., Levanon E.Y., Zhao J., Avivi A., Larkin D.M., … Farré M., Kim J., et al. Genome-wide adaptive complexes to underground stresses in blind mole rats, Spalax. Nature communications 2014 Jun3;5:3966.
  11. Ullastres A., Farré M., Capilla L., Ruiz-Herrera A. Unravelling the effect of genomic structural changes on genetic recombination in the rhesus macaque - implications for the adaptive role of inversions. BMC Genomics 2014 Jun 26;15(1):530.
  12. Wang W., Lopez-Giraldez F., Farré M., Lehr N., Townsed JF. Global gene expression and knockout analysis reveals genes associated with fungal fruiting body development in Neurospora crassa. Eukaryot Cell. 2013 Nov 15.
  13. Segura J., Capilla L., Ferreti L., Ramos-Onsins S., Farré M., Reis F., Garcia F., Garcia-Caldes M., Robinson TJ., Ruiz-Herrera A., New insights into mechanisms that are shaping meiotic recombination rates and crossover interference in eutherian mammals. Proc. R. Soc. B. 2013 Jan 1; 48-218-28.
  14. Farré M., Michelleti D., Ruiz-Herrera A., Recombination rates and genomic shuffling in human and chimpanzee – a new twist in the chromosomal speciation theory. Mol Biol Evol. 2013 Apr(4): 853-864.
  15. Ruiz-Herrera A., Farré M., Robinson TJ. Molecular cytogenetic and genomic insights to chromosomal evolution. Heredity 2012; 108(1):28-36.
  16. Farré M, Bosch M, López-Giraldez F, Ponsà M, Ruiz-Herrera A. Assessing the role of tandem repeats in shaping genomic architecture of Great Apes. PLoS One 2011; 6(11).
  17. Ruiz-Herrera A., Farré M., Ponsà M., Robinson TJ. Selection against Robertsonian fusions involving housekeeping genes in the house mouse: integrating data from gene expression arrays and chromosome evolution. Chromosome Res 2010; 18:801-808.
  18. Farré M, Ponsà M, Bosch M. Interstitial telomeric sequences (ITS) are not located at the exact evolutionary breakpoints in primates. Cytogenet Genome Res. 2009; 124(2): 128-31. ?


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