Department: Pathobiology and Population Sciences

Campus: Camden

Laura is an Innovation Fellow -The Bloomsbury SET. Her reseacrh aims to develop a fast diagnostic tool for infectious disease in cattle by mining RNA unmapped reads.

Laura moved to London in 2016 and was awarded a Marie Sklodowska Curie fellowship “Bioinformatics4Breeding” at the Royal Veterinary College (2016-2018) working with Professors Denis Larkin and Claire Wathes.

For more information see: Bioinformatics4Breeding project summary

 

The main aim of the current project is to develop a diagnostic tool for pathogen discovery in cattle based on whole blood transcriptome analysis. I am currently working on develop a computational approach to pathogen discovery based on bioinformatic analysis of existing RNA seq data from whole blood. We will then validate this approach by collecting new samples, and further we will perform a scoping study of the potential commercial value of the technology to farmers and to public-sector disease surveillance programmes.

Bernabucci, U., Biffani, S., Buggiotti, L., Vitali, A., Lacetera, N., and Nardone, A. (2014). The effects of heat stress in Italian Holstein dairy cattle. J. Dairy Sci. 97, 471–486.

Frangella, C., Isabella, A., Montuori, E., Giampaoli, S., Buggiotti, L., Marigliano, B., Gianturco, V., Romanelli, R., Giordano, R., Marigliano, V., et al. (2012). [Adapted physical activity: the role in secondary prevention of the osteoporosis]. Recenti Prog. Med. 103, 164–172.

Giampaoli, S., Berti, A., Valeriani, F., Gianfranceschi, G., Piccolella, A., Buggiotti, L., Rapone, C., Valentini, A., Ripani, L., and Romano Spica, V. (2012). Molecular identification of vaginal fluid by microbial signature. Forensic Sci. Int. Genet. 6, 559–564.

Lehtonen, P.K., Laaksonen, T., Artemyev, A.V., Belskii, E., Berg, P.R., Both, C., Buggiotti, L., Bureš, S., Burgess, M.D., Bushuev, A.V., et al. (2012). Candidate genes for colour and vision exhibit signals of selection across the pied flycatcher (Ficedula hypoleuca) breeding range. Heredity 108, 431–440.

Valeriani, F., Giampaoli, S., Buggiotti, L., Gianfranceschi, G., and Romano Spica, V. (2012). Molecular enrichment for detection of S. aureus in recreational waters. Water Sci. Technol. J. Int. Assoc. Water Pollut. Res. 66, 2305–2310.

Minozzi, G. and Buggiotti, L., Stella, A., Strozzi, F., Luini, M., and Williams, J.L. (2010). Genetic loci involved in antibody response to Mycobacterium avium ssp. paratuberculosis in cattle. PloS One 5, e11117.

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