Department: Pathobiology and Population Sciences

Campus: Hawkshead

Research Groups: Host-Pathogen Interactions and Vaccinology, Safe and Sustainable Food

Carole is a lecturer in virology within the Department of Pathobiology & Population Sciences. She is deputy module leader for the 'Principles of Science' strand of BVetMed, with particuar focus on years 1 and 2.

Carole completed her PhD in molecular virology at the Institute of Virology,Oxford, charactersing genes involved in the replication of the insect vius AcMNPV. After post-doctoral research into improvements of recombinant protein expression from the insect virus system she joined Professor Joe Brownlie's group at the RVC to work on BVDV vaccine development. Following an RCUK fellowship Carole was made lecturer in 2012.

Carole research interests in virology include host-pathogen interactions, vaccine development and BVD virus virulence.

R El-Attar LM, Thomas C, Luke J, A Williams J, Brownlie J. (2015). Enhanced neutralising antibody response to bovine viral diarrhoea virus (BVDV) induced by DNA vaccination in calves. Vaccine. 33(32):4004-12.

Booth RE, Thomas CJ, El-Attar LM, Gunn G, Brownlie J. (2013). A phylogenetic analysis of Bovine Viral Diarrhoea Virus (BVDV) isolates from six different regions of the UK and links to animal movement data.  Vet Res. 19;44:43.

Iourin O, Harlos K, El Omari K, Lu W, Kadlec J, Iqbal M, Meier C, Palmer A, Jones I, Thomas C, Brownlie J, Grimes JM, Stuart DI. (2013).  Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus.  Acta Crystallogr Sect F Struct Biol Cryst Commun. 69(Pt 1):35-8.

Burr S, Thomas C, Brownlie J, Offord V, Coffey TJ, Werling D. (2012). Potential evidence for biotype-specific chemokine profile following BVDV infection of bovine macrophages. Vet Immunol Immunopathol. 150(1-2):123-7.

Anstaett OL, Brownlie J, Collins ME, Thomas CJ. (2010). Validation of endogenous reference genes for RT-qPCR normalisation in bovine lymphoid cells (BL-3) infected with Bovine Viral Diarrhoea Virus (BVDV).  Vet Immunol Immunopathol. 137(3-4): 201-7.

Collins ME, Heaney J, Thomas CJ, Brownlie J. (2009). Infectivity of pestivirus following persistence of acute infection.  Vet Microbiol. 138: 289-96.

Thomas C, Young NJ, Heaney J, Collins ME, Brownlie J.  Evaluation of efficacy of mammalian and baculovirus expressed E2 subunit vaccine candidates to bovine viral diarrhoea virus.  Vaccine. 2009 Apr 14;27(17):2387-93.

Young NJ, Thomas CJ, Collins ME, Brownlie J.  Real-time RT-PCR detection of Bovine Viral Diarrhoea virus in whole blood using an external RNA reference.  J Virol Meth. 2006 Dec;138(1-2):218-22.

Young N, Thomas CJ, Thompson I, Collins ME and Brownlie J. Immune responses to NS3 of BVDV in NS3 vaccinated and naturally infected cattle. J. Prev Vet Med (2005) 72,115-120

Saville GP, Thomas CJ, Possee RD and King LA (2002). Partial redistribution of the Autographa californica nucleopolyhedrovirus chitinase in virus-infected cells accompanies mutation of the carboxy-terminal KDEL ER-retention motif. J. Gen Virol. 83, 685-94.

Thomas CJ, Gooday GW, King LA and Posse RD (2000). Mutagenesis of the active site coding region of the Autographa californica nucleopolyhedrovirus chiA gene.  J. Gen. Virol 81, 1403-11

Carole teaches on the BSc, BVetMed, Accelerated BVetMed and VN courses at the RVC. She is deputy module leader of the PoS strand on BVetMed. She is a tutor for students on Accelerated BVetMed and PG student tutor. She has a PGCE in Veterinary Education (RVC) and is a fellow of the higher education academy.

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