Department: Pathobiology and Population Sciences
Research Groups: Host-Pathogen Interactions and Vaccinology
Research Centres: Veterinary Epidemiology, Economics and Public Health
Research Fellow developing novel diagnostics for tuberculosis and investigating the spread antimicrobial resistance (AMR) in the environment.
Mycobacteria are responsible for a range of diseases, including (among others) tuberculosis that effect animals and people. Mycobacterial diseases lead to a large number of deaths, economic hardship both in the UK and in Low-middle income countries (LMICs). Diagnostics are thought to be one of the key tools that need to be developed to help tackle these infections (WHO).
During my PhD at the University of Nottingham I developed novel diagnostics for mycobacterial diseases, based on using bacteriophage. I successfully patented this technology and here at the RVC I am currently funded to further develop this and novel technology further to aid the diagnosis of mycobacterial diseases in human and veterinary settings.
Antimicrobial resistance (AMR) is thought to be one of the biggest challenges of our time. Antibiotic resistant infections will result in millions of deaths and a huge impact on society, without strong interdisciplinary research.
Here at the RVC I am involved in researching drivers of antimicrobial resistance (AMR) in the environment, where I aim to fill in the significant gaps in research in this area, to address the potential risks the environment poses in the spread of AMR, both in the UK and in low-middle income countries.
I am very interested in applied biology and translating research from bench to consumer. I am keen to collaborate with academia and industry.
Currently active projects:
Development and use of novel tools to detect mycobacteria.
- BloomsburySET Fellowship, Research England
- CCF, PBD Biotech - Diagnosing TB in human blood
Drivers of AMR in the Environment
- Investigating the prevalence and spread of Salmonella in wildlife and characterising their antimicrobial resistance profiles. RVC IGS, Universty of Nottingham
- Developing risk metrics for AMR in Kenya. LIDC
- Prevalence of AMR in chicken farms in England
'TB on the edge' - Investigating the spread of TB in badgers on the endemic edge in England
- Defra, University of Nottingham, University of Surrey, University of Liverpool
Swift, B., Bennett, M., Waller, K., Dodd, C., Murray, A., Gomes, R., Humphreys, B., Hobman, J., Jones, M., Whitlock, S., Mitchell, L., Lennon, R., Arnold, K. 2018. Anthropogenic environmental drivers of antimicrobial resistance in wildlife. STOTEN. 649. 12-20
Barron, E., Swift, B., Chantrey, J., Christley, R., Gardner, R., Jewell, C., McGrath, I., Mitchell, A., O’Cathail, C., Prosser, A., Ridout, S, Sanchez, G., Smith, N., Timofte, D., Williams, N., Bennett, M. 2018. A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area. Sci Reports.
Gerrard, Z., Swift, B., Botsaris, G., Davidson, R., Hutchings, M., Huxley, J., Rees, C. Survival of Mycobacterium avium subspecies paratuberculosis in retail pasteurised milk. 2018. Food Micro. 74: 57-63.
Donnellan, S., Stone, V., Johnston, H., Giardiello, M., Owen, A., Rannard, S., Aljayyoussi, G., Swift, B., Tran, L., Watkins, C., and Stevenson, K. 2017. Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity. Journal of Interdisciplinary Nanomedicine, 2: 146–156. doi: 10.1002/jin2.27.
Swift, B. M. C., Huxley, J. N., Plain, K. M., Begg, D. J., de Silva, K., Purdie, A. C., Whittington, R. J., Rees, C. E. D. 2016. Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle. BMC Veterinary Research. DOI: 10.1186/s12917-016-0728-2.
Swift, B. M. C., Convery, T. W. & Rees, C. E. D. 2016. Evidence of Mycobacterium tuberculosis Complex bacteraemia in intradermal skin test positive cattle detected using phage-RPA. Virulence. Page 6 of 35 DOI:10.1080/21505594.2016.1191729.
Botsaris, G., Swift. B.M.C., Slana, I., Liapi, M., Christodoulou, M., Hatzitofi, M., Christodoulou, V. & Rees C.E.D. 2016. Detection of viable Mycobacterium avium subspecies paratuberculosis in powdered infant formula by phage-PCR and confirmed by culture. International Journal of Food Microbiology, 216, 91-4.
Swift, B. M., Gerrard, Z. E., Huxley, J. N. & Rees, C. E. 2014. Factors Affecting Phage D29 Infection: A Tool to Investigate Different Growth States of Mycobacteria. PLoS One, 9, e106690.
Swift, B. M. C., Denton, E. J., Mahendran, S. A., Huxley, J. N., Rees, C. E. D. 2013. Development of a rapid phage-based method for the detection of viable Mycobacterium avium subsp. paratuberculosis in blood within 48 h. Journal of Microbiological Methods, 94, 175-179.
Rees, C. E. D., Swift. B. M. C., Botsaris, G. 2013. Bacteriophage-Based Techniques for Detection of Foodborne Pathogens. ENCYCLOPEDIA OF FOOD MICROBIOLOGY, SECOND EDITION.
Swift, B. M. & Rees, C. E. D. 2013. Detecting mycobacteria in cattle blood. Vet Rec, 173, 522-3.
Swift and Rees (2013) GB Patent 1317392.7. Entitled: “MYCOBACTERIA DETECTION”.
I am very interested in outreach and happy to be contacted about any opportunities.
Modelling exposure to biological hazards in the dairy chains of Andhra Pradesh to inform food safety policy
The dairy industry in Andhra Pradesh is intensifying and its output increasing to satisfy the growing demand for milk and dairy products, but this expansion has taken place without food safety challenges being fully addressed. This project combines microbiological surveys of milk and dairy products, probabilistic modelling of the likely impact of control strategies and strong stakeholder engagement including participatory model building to explore the broad implications of milk hygiene policies and identify gender based constraints.