Department: Clinical Sciences and Services

Campus: Camden

Research Groups: Immune Regulation and Cancer

Clinical Groups: Small Animal Internal Medicine

Research Centres: RVC Quantitative Biology Resource, Clinical Investigation Centre, Imaging Suite

Oliver is Professor of Comparative Medicine and Immunology. His research focuses on regulatory T cells in dogs and mice in both the healthy organism and in the context of autoimmune disease and cancer. He is also a clinician in the Queen Mother Hospital for Animals, the largest small animal referral centre in Europe.

Oliver graduated from the Royal Veterinary College (RVC) in 1993, having completed an intercalated BSc at King's College London in 1990. Following a rotating internship in small animal medicine and surgery, he successfully completed a Wellcome Trust Clinical PhD programme in small animal gastroenterology and immunology at the RVC in 1998 and then a Wellcome Trust Research Training Fellowship at the University of South Carolina Medical School in 1999.

From 1999 to 2001, Oliver completed a Residency in Small Animal Internal Medicine at Cornell University. Between 2001­ and 2004, Oliver undertook a Wellcome Trust Advanced Fellowship within the Department of Immunology at Imperial College London (ICL), Hammersmith Campus, under the sponsorship of Professor Sir Robert Lechler. Oliver also gained the DipACVIM in 2002 and the DipECVIM-­CA in 2003. He became an Honorary Lecturer in the Department of Immunology at ICL in 2003, and from 2004 has held an appointment with the RVC as a Senior Lecturer, Reader and then Professor of Comparative Medicine and Immunology. Oliver is a member of the Comparative Physiology and Medicine and Infection and Immunity research themes at the RVC, and he leads the Oncology Special Interest Group (part of Comparative Physiology and Medicine).

 

IMMUNE REGULATION LABORATORY

Introduction

Professor Oliver Garden’s laboratory, based at the Camden Campus of the Royal Veterinary College, specialises in cellular immunology, with a specific expertise in regulatory T cell (Treg) and myeloid-derived suppressor cell (MDSC) biology. Oliver started his laboratory with the aid of a Wellcome Trust Advanced Fellowship in 2001 within the Department of Immunology, Imperial College London, Hammersmith Campus, following post-doctoral training at the University of South Carolina Medical School and a Residency in Small Animal Internal Medicine at Cornell University.

Successful BSc, MSc and PhD projects

To date, six PhD students, three BSc students and 14 MSc students have successfully graduated following projects carried out within Oliver’s laboratory. Of the MSc students, ten gained Distinctions for their projects and all but two have completed – or are currently completing – successful PhD projects. Of the PhD students, all completed their theses within three or four years (depending on the programme) and have carved out successful careers in research, medical practice or (in one case) patent law.

The laboratory has also employed two Research Technicians, who both moved on to prestigious Research Associate posts – one at King’s College London and the other at University College London – following the conclusion of their contracts, and one postdoctoral Fellow (Dr Dammy Pinheiro), who has moved on to a senior postdoctoral post within the School of Biological Sciences at the University of Reading.

The laboratory is currently home to two PhD students, one of whom (Julia Wu) is studying the role of lymphoid and myeloid regulatory cells in canine diffuse large cell B cell lymphoma and the other of whom (Michael Denyer) is studying the evolutionary phylogeny of immune tolerance in collaboration with Dr Adrian Shepherd at Birkbeck; Michael has already submitted his first manuscript for publication, so has got off to a flying start! The laboratory hosts from one to three undergraduate or postgraduate students – undertaking BSc, BVetMed or MSc degrees – at any one time; we are currently home to both a BSc and an MSc student. We are also delighted to announce the recruitment of Dr Michelle Goulart, who has joined the laboratory from the University of Oregon as a Postdoctoral Research Fellow in Cancer Immunology, and are proud to welcome back Dr Dammy Pinheiro, a Visiting Scientist from the University of Reading, who completed her PhD and a postdoctoral Fellowship in Oliver's laboratory.

Key expertise and funding

Key techniques for which Oliver’s laboratory has specific expertise include T cell culture, including sophisticated Treg assays in vitro; multi-colour analytical flow cytometry; ELISAs of a number of Th1 and Th2 cytokines; and molecular biological techniques, including PCR, cloning and transduction of constructs into mammalian cells.

Total extra-mural grant income since 2003 has been ≈ £1.5m, including industrial sources, the Medical Research Council, Mizutani Foundation for Glycoscience, Commonwealth Scholarship Commission, Biotechnology and Biological Research Council (BBSRC), European College of Veterinary Internal Medicine (ECVIM), Italian Ministry of Health, American College of Veterinary Emergency and Critical Care (ACVECC), Wellcome Trust, and Petplan Charitable Trust (PPCT).  Current funding includes grants from the BBSRC, PPCT and various commercial sponsors.

Delivering for industry

Oliver’s laboratory has successfully worked with five major industrial partners over the past eight years, consistently delivering on-time and within budget – for both product-orientated projects and blue-sky research. The laboratory has a dynamic, forward-looking, innovative and committed work ethic – with an unquestionable dedication to its team members, to its academic funders and to its industrial partners.

The biennial Treg/Th Cell Symposium

Oliver is the coordinator for a biennial series of one-day symposia "Treg: Regulatory T Cells and T Helper Cells", the first one of which (March 2012) focused on ontogeny, plasticity and clinical applications. See the Proceedings notes for the first of these exciting events, published in Immunology. These meetings are organised with the help of the RVC Continuing Professional Development Unit. Six world-class speakers came to the RVC to share their research findings in March of 2012, supported by three short oral communications and a number of poster presentations by PhD students and post-doctoral scientists.

The second of these exciting symposia was held at the RVC on 25th April 2014. Speakers included Professors JOACHIM SCHULTZE, AWEN GALLIMORE, LUCY WALKER and ANNE COOKE, and Drs JEFF DAVIES and MEGAN MacLEOD. Please see "Treg: Regulatory T Cells and T Helper Cells" for details. Proceedings notes were published in Immunology, as well as a meeting review by Julia Wu in Immunology News.

Research awards

Two of Oliver's publications have recently been recognised by prestigious awards:

(1) His review of systemic inflammatory response syndrome and sepsis, for which the first-named author is Dan Lewis, won an award for being one of the top five most downloaded publications in the Journal of Veterinary Internal Medicine in 2013, being downloaded a total of 6,372 times in this time period.

(2) His study of duodenal lesions in diet-responsive chronic enteropathy, for which the first-named author is David Walker, won a European Emesis Council / European Society of Comparative Gastroenterology award for the best gastrointestinal publication from a European research group in 2013.

SINGH, Y, GARDEN, OA, LANG, F and COBB, BS (2016) Retroviral transduction of helper T cells as a genetic approach to study mechanisms controlling their differentiation and function. Journal of Visualized Experiments Nov 4 (117): doi 10.3791/54698. PMID: 27842353

LOWRIE, M, HADJIVASSILIOU, M, SANDERS, DS and GARDEN, OA (2016) A presumptive case of gluten sensitivity in a Border terrier: a multisystem disorder? Veterinary Record Oct 26: doi 10.1136/vr.103910. PMID: 27784836

GIULIANO, A, SWIFT, R, ARTHURS, C, MAROTE, G, ABRAMO, F, McKAY, J, THOMSON, C, BELTRAN, M, MILLAR, M, PRIESTNALL, S, DOBSON, J, COSTANTINO-CASAS, F, PETROU, T, McGONNELL, IM, DAVIES, AJ, WEETMAN, M, GARDEN, OA, MASTERS, JR, THRASIVOULOU, C and AHMED, A (2016) Quantitative expression and co-localization of Wnt signalling related proteins in feline squamous cell carcinoma. PLOS ONE 11 (8): e0161103. PMID: 27559731 

FORTUNA, L, RELF, J, CHANG, YM, HIBBERT, A, MARTINEAU, HM and GARDEN, OA (2016) Prevalence of FoxP3+ cells in canine tumours and lymph nodes correlates positively with glucose transporter 1 expression. Journal of Comparative Pathology 155: 171-180. PMID: 27435834

MARCONATO, L, POLTON, GA, SABATTINI, S, DACASTO, M, GARDEN, OA, GRANT, I, HENDRICKX, T, HENRIQUES, J, LUBAS, G, MORELLO, E, STEFANELLO, D and COMAZZI, S; EUROPEAN CANINE LYMPHOMA NETWORK (2016) Conformity and controversies in the diagnosis, staging and follow-up evaluation of canine nodal lymphoma: a systematic review of the last 15 years of published literature. Veterinary and Comparative Oncology Jul 14: doi 10.1111.vco.12244. PMID: 27412493

SINGH, Y, GARDEN, OA, LANG, F and COBB, BS (2016) miRNAs regulate T cell production of IL-9 and identify hypoxia inducible factor-2α (HIF-2α) as an important regulator of Th9 and Treg differentiation. Immunology Jun 9: doi 10.1111/imm.12631. PMID: 27278750

AGUIAR, J, CHANG, YM and GARDEN, OA (2016) Complications of percutaneous endoscopic gastrostomy in dogs and cats receiving corticosteroid treatment. Journal of Veterinary Internal Medicine May 23: doi 10.1111/jvim.13969. PMID: 27214641

COMAZZI, S, AVERY, PR, GARDEN, OA, RIONDATO, F, RUTGEN, B, VERNAU, W, European Canine Lymphoma Network (2016) European canine lymphoma network consensus recommendations for reporting flow cytometry in canine hematopoietic neoplasms. Cytometry B Clinical Cytometry May 12: doi 10.1002/cyto.b.21382 PMID: 27170500

SWANN, JW and GARDEN, OA (2016) Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people. Veterinary Journal 207: 13-19. PMID: 27152382

CARNEY, K, CHANG, YM, WILSON, S, CALNAN, C, REDDY, PS, CHAN, WY, GILMARTIN, T, HERNANDEZ, G, SCHAFFER, L, HEAD, SR, MORLEY, J, de MESTRE, A, AFFLECK, K and GARDEN, OA (2016) Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function. Journal of Allergy and Clinical Immunology 137 (6): 1907-1909. PMID: 27040371

DENYER, MP, PINHEIRO, DY, GARDEN, OA and SHEPHERD, AJ (2016) Missed, not missing: phylogenomic evidence for the existence of avian FoxP3. PLOS ONE 11 (3): e0150988. PMID: 26938477

CHANG, YM, HADOX, E, SZLADOVITS, B and GARDEN, OA (2016) Serum biochemical phenotypes in the domestic dog . PLOS ONE  11 (2): e0149650. PMID: 26910479 

PETERS, LM, GLANEMANN, B, GARDEN, OA and SZLADOVITS, B (2015) Cytological findings of 140 bile samples from dogs and cats and associated clinical pathological data. Journal of Veterinary Internal Medicine 30 (1): 123-131. PMID: 26566964

SINGH, Y, GARDEN, OA, LANG, F and COBB, BS (2015) MicroRNA-15b/16 enhances the induction of regulatory T cells by regulating the expression of Rictor and mTOR. Journal of Immunology 195 (12): 5667-5677. PMID: 26538392

LOWRIE, M, GARDEN, OA, HADJIVASSILOU, M, HARVEY, RJ, SANDERS, DS, POWELL, R and GAROSI, L (2015) The clinical and serological effect of a gluten-free diet in Border terriers with epileptoid cramping syndrome. Journal of Veterinary Internal Medicine 29 (6): 1564-1568. PMID: 26500168

SWANN, JW, PRIESTNALL, SL, DAWSON, C, CHANG, YM and GARDEN, OA (2015) Histologic and clinical features of primary and secondary vasculitis: a retrospective study of 42 dogs (2004-2011). Journal of Veterinary Diagnostic Investigation 27 (4): 489-496. PMID: 26077546

SCHMITZ, S, GLANEMANN, B, GARDEN, OA, BROOKS, H, CHANG, YM, WERLING, D and ALLENSPACH, K (2015) A prospective, randomized, blinded, placebo-controlled pilot study on the effect of Enterococcus faecium on clinical activity and intestinal gene expression in canine food-responsive chronic enteropathy. Journal of Veterinary Internal Medicine 29 (2): 533-543. PMID: 25776251

PINHEIRO, D, CHANG, YM, BRYANT, H, SZLADOVITS, B, DALESSANDRI, T, DAVISON, LJ, YALLOP, E, MILLS, E, LEO, C, LARA, A, STELL, A, POLTON, G and GARDEN, OA (2014) Dissecting the regulatory microenvironment of a large animal model of non-Hodgkin lymphoma: evidence of a negative prognostic impact of FOXP3+ T cells in canine B cell lymphoma. PLOS ONE 9 (8): e105027. PMID: 25119018

ANFINSEN, KP, PIERCY, RJ, MASSEY, C, SMITH, KC, KENNY, PJ and GARDEN, OA (2014) Severe systemic calciphylaxis in a young cat. Journal of Veterinary Internal Medicine 28 (4): 1325-1330. PMID: 24903891

HARDY, JI, HENDRICKS, A, LOEFFLER, A, CHANG, YM, VERHEYEN, KL, GARDEN, OA and BOND, R (2014) Food-specific serum IgE and IgG reactivity in dogs with and without skin disease: lack of correlation between laboratories. Veterinary Dermatology 25 (5): 447-e70. PMID: 24890097

FERREIRA, C, PALMER, D, BLAKE, K, GARDEN, OA and DYSON, J (2014) Reduced regulatory T cell diversity in NOD mice is linked to early events in the thymus. Journal of Immunology 192 (9): 4145-4152. PMID: 24663675

LAWRENCE, J, CHANG, Y-M, SZLADOVITS, B, DAVISON, LJ and GARDEN, OA (2013) Breed-specific hematological phenotypes in the dog: a natural resource for the genetic dissection of hematological parameters in a mammalian species. PLOS ONE 8 (11): e81288. PMID: 24282579

WALKER, D, KNUCHEL-TAKANO, A, McCUTCHAN, A, CHANG, YM, DOWNES, C, MILLER, S, STEVENS, K, VERHEYEN, K, PHILLIPS, AD, MIAH, S, TURMAINE, M, HIBBERT, A, STEINER, JM, SUCHODOLSKI, JS, MOHAN, K, EASTWOOD, J, ALLENSPACH, K, SMITH, K and GARDEN, OA (2013) A comprehensive pathological survey of duodenal biopsies from dogs with diet-responsive chronic enteropathy. Journal of Veterinary Internal Medicine 27 (4): 862-874. PMID: 23663231 

KIDDER, D, RICHARDS, HE, ZILTENER, HJ, GARDEN, OA and CROCKER, PR (2013) Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. Journal of Immunology 190 (6): 2593-2602. PMID: 23408841

BURR, SP, DAZZI, F and GARDEN, OA (2013) Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance? Immunology and Cell Biology 91 (1): 12-18. PMID:23146942

SOOND, DR, SLACK, EC, GARDEN, OA, PATTON, DT and OKKENHAUG, K (2012) Does the PI3K pathway promote or antagonize regulatory T cell development and function? Frontiers in Immunology 3: 244. PMID: 22912633

SOOND, DR, GARCON, F, PATTON, DT, ROLF, J, TURNER, M, SCUDAMORE, C, GARDEN, OA and OKKENHAUG, K (2012) Pten loss in CD4+ T cells enhances their helper function but does not lead to autoimmunity or lymphoma. Journal of Immunology 188 (12): 5935-5943. PMID: 22611241

LEWIS, DH, CHAN, DL, PINHEIRO, D, ARMITAGE-CHAN, E and GARDEN, OA (2012) The immunopathology of sepsis: pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response and regulatory T cells. Journal of Veterinary Internal Medicine 26 (3): 457-482. PMID:22428780

SCHMITZ, S, GARDEN, OA, WERLING, D and ALLENSPACH, K (2012) Gene expression of selected signature cytokines of T cell subsets in duodenal tissues of dogs with and without inflammatory bowel disease. Veterinary Immunology and Immunopathology 146 (1): 87-91. PMID:22333286

SINGH, Y, DYSON, J and GARDEN, OA (2011) Use of SNARF-1 to measure murine T cell proliferation in vitro and its application in a novel regulatory T cell suppression assay. Immunology Letters 140 (1-2): 21-29. PMID:21664378

KATHRANI, A, SCHMITZ, S, PRIESTNALL, SL, SMITH, KC, WERLING, D, GARDEN, OA and ALLENSPACH, K (2011) CD11c+ cells are significantly decreased in the duodenum, ileum and colon of dogs with inflammatory bowel disease. Journal of Comparative Pathology 145 (4): 359-366. PMID:21592490

GARDEN, OA, PINHEIRO, DY and CUNNINGHAM, F (2011) All creatures great and small: regulatory T cells in mice, humans, dogs and other domestic animal species. International Immunopharmacology 11 (5): 576-588. PMID:21093606

PINHEIRO, D, SINGH, Y, GRANT, C, APPLETON, RC, SACCHINI, F, WALKER, KRL, CHADBOURNE, AH, PALMER, CA, ARMITAGE-CHAN, E, THOMPSON, I, WILLIAMSON, L, CUNNINGHAM, F and GARDEN, OA (2011) Phenotypic and functional characterisation of a CD4+CD25highFOXP3high regulatory T cell population in the dog. Immunology 132 (1): 111-122. PMID:20880379

BAILEY, S, BENIGNI, L, EASTWOOD, J, GARDEN, OA, McMAHON, L, SMITH, K, STEINER, JM, SUCHODOLSKI, JS and ALLENSPACH, K (2010) Comparisons between cats with normal and increased fPLI concentrations in cats diagnosed with inflammatory bowel disease. Journal of Small Animal Practice 51 (9): 484-489. PMID:21050218

SINGH, Y, FERREIRA, C, CHAN, AC, DYSON, J and GARDEN, OA (2010) Restricted TCR-alpha CDR3 diversity disadvantages natural regulatory T cell development in the B6.2.16 beta chain transgenic mouse. Journal of Immunology 185 (6): 3408-3416. PMID:20713881 

GAJANAYAKE, I, PRIESTNALL, SL, BENIGNI, L, ENGLISH, K, SUMMERS, B and GARDEN, OA (2010) Paraneoplastic hypercalcemia in a dog with benign renal angiomyxoma. Journal of Veterinary Diagnostic Investigation 22 (5): 775-780. PMID:20807942

ALLENSPACH, K, HOUSE, A, SMITH, K, MNNEILL, FM, HENDRICKS, A, ELSON-RIGGINS, J, RIDDLE, A, STEINER, JM, WERLING, D, GARDEN, OA, CATCHPOLE, B and SUCHODOLSKI, JS (2010) Evaluation of mucosal bacteria and histopathology, clinical disease activity and expression of Toll-like receptors in German shepherd dogs with chronic enteropathies. Veterinary Microbiology 146 (3-4): 326-335. PMID:20615633 

CARLUCCI, F, FOSSATI-JIMACK, L, DUMITRIU, IE, HEIDARI, Y, WALPORT, MJ, SZAJNA, M, BARUAH, P, GARDEN, OA, COOK, HT and BOTTO, M (2010) Identification and characterization of a lupus suppressor 129 locus on chromosome 3. Journal of Immunology 184 (11): 6256-6265. PMID:20435933

FERREIRA, C, SINGH, Y, FURMANSKI, AL, WONG, FS, GARDEN, OA and DYSON, J (2009) Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proceedings of the National Academy of Sciences (USA) 106 (20): 8320-8325. PMID:19359477

KATHRANI, A, STEINER, JM, SUCHODOLSKI, J, EASTWOOD, J, SYME, H, GARDEN, OA and ALLENSPACH, K (2009) Elevated canine pancreatic lipase immunoreactivity concentration in dogs with inflammatory bowel disease is associated with a negative outcome. Journal of Small Animal Practice 50 (3): 126-132. PMID:19261082

KOHLHAAS, S, GARDEN, OA, SCUDAMORE, C, TURNER, M, OKKENHAUG, K and VIGORITO, E (2009) Cutting Edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. Journal of Immunology 182 (5): 2578-2582 (dual first authorship). PMID:19234151

HASLAM, SM, JULIEN, S, BURCHELL, JM, MONK, CR, CERONI, A, GARDEN, OA and DELL, A (2008) Characterizing the glycome of the mammalian immune system. Immunology and Cell Biology 86 (7): 564-573. PMID:18725885

ISAACS, J D, GARDEN, OA, KAUR, G, COLLINGE, J, JACKSON, GS and ALTMANN, DM (2008) The cellular prion protein is preferentially expressed by CD4+ CD25+ Foxp3+ regulatory T cells. Immunology 125 (3): 313-319. PubMed ID 18462346

YATES, J, ROVIS, F, MITCHELL, P, AFZALI, B, TSANG, JY, GARIN, M, LECHLER, RI, LOMBARDI, G and GARDEN, OA (2007) The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. International Immunology 19: 785-799. PubMed ID 17545278

GARDEN, OA, REYNOLDS, PR, YATES, J, LARKMAN DJ, MARELLI-BERG FM, HASKARD DO, EDWARDS AD and GEORGE AJT (2006) A rapid method for labelling CD4+ T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro. Journal of Immunological Methods 314 (1-2): 123-133. PMID:16860821

PATTON, DT, GARDEN, OA, PEARCE, WP, CLOUGH, LE, MONK, CR, LEUNG, E, ROWAN, WC, SANCHO, S, WALKER, LS, VANHAESEBROECK, B and OKKENHAUG, K (2006) Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. Journal of Immunology 177: 6598-6602. PubMed ID 17082571

MONK, CR, SUTTON-SMITH, M, DELL, A and GARDEN, OA (2006) Preparation of CD25+ and CD25- CD4+ T cells for glycomic analysis--a cautionary tale of serum glycoprotein sequestration. Glycobiology 16: 11G-13G. PubMed ID 16770844

GARDEN, OA, REYNOLDS, PR, YATES, J, LARKMAN, DJ, MARELLI-BERG, FM, HASKARD, DO, EDWARDS, AD and GEORGE, AJ (2006) A rapid method for labelling CD4+ T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro. Journal of Immunological Methods 314: 123-133. PubMed ID 16860821

MONK, CR, SPACHIDOU, M, ROVIS, F, LEUNG, E, BOTTO, M, LECHLER, RI and GARDEN, OA (2005) MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis and Rheumatism 52: 1180-1184. PubMed ID 15818683

ROVIS, F, WAIT, R, LEE, BBC, MONK, CR, LECHLER, RI and GARDEN, OA (2004) Proteomic characterization of murine CD4+CD25+ regulatory T cells. Immunology 2004. Vol. ISBN 88-7587-069-1, pp. 79-84. Bologna: Medimond Srl.

LECHLER, RI, GARDEN, OA and TURKA, LA (2003) The complementary roles of deletion and regulation in transplantation tolerance. Nature Reviews in Immunology 3: 147-158. PubMed ID 12563298

GARDEN, OA (2001) Genetic modelling of intestinal disease: the paradigm of gluten-sensitive enteropathy in the Irish setter dog – a model for human coeliac disease? The European Journal of Comparative Gastroenterology 10: 2-12.

RICH, IN, WORTHINGTON-WHITE, D, GARDEN, OA and MUSK, P (2000) Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na+/H+ exchanger. Blood 95: 1427-1434. PubMed ID 10666221

GARDEN, OA, PIDDUCK, H, LAKHANI, KH, WALKER, D, WOOD, JL and BATT, RM (2000) Inheritance of gluten-sensitive enteropathy in Irish Setters. American Journal of Veterinary Research 61: 462-468. PubMed ID 10772115

GARDEN, OA, MUSK, P, WORTHINGTON-WHITE, DA, DEWEY, MJ and RICH, IN (2000) Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls. Cancer Genetics and Cytogenetics 120: 37-43. PubMed ID 10913675

Teaching undergraduate and postgraduate students

Oliver is a Fellow of the Higher Education Academy, having completed the Certificate of Advanced Studies in Learning and Teaching at Imperial College London (ICL) in 2005. He teaches at both the RVC and ICL. His teaching portfolio at the RVC includes lectures on immune-mediated disease and feline infectious disease, delivered to the Fourth Year BVetMed students; a role as leader of the Feline Medicine Post-Rotation Taught Tracking (PRTT; Elective) Module, on which he lectures and presents cases in the format of problem-based learning; and both structured and ad hoc teaching on the clinic floor of the Queen Mother Hospital for Animals. Oliver has directed the programme of research projects ('Research Project 2') and PRTT (Elective) modules for the Final Year students for the past five years.

His teaching responsibilities at ICL include lectures on dendritic cells, immunological tolerance, Th1/2/17 cells, regulatory T cells and systemic lupus erythematosus. He presents to the MSc students within the Section of Immunobiology, Department of Medicine, acting as a teacher, Course Tutor and examiner for the MSc degree. His particular pedagogical interest is maximising the effectiveness of ad hoc clinical teaching on the hospital floor.

Visiting Professorships

Oliver is a Visiting Professor in Comparative Medicine and Immunology at the Centre for Haemato-Oncology, Barts Cancer Institute, School of Medicine and Dentistry, Queen Mary University of London and the Section of Immunobiology, Department of Medicine, Hammersmith Campus, ICL.

Oliver is a member of the Small Animal Internal Medicine team within the Queen Mother Hospital for Animals (QMHA), seeing dogs and cats with all manner of medical problems. His particular clinical interests include gastrointestinal and immune-mediated disease; Oliver has contributed chapters on immune-mediated disease and gastrointestinal immunology to two widely read textbooks in the field.

Oliver is also involved in the teaching and supervision of both Junior and Senior Clinical Training Scholars (Interns and Residents) in the QMHA, having contributed to the training of 43 Junior and 57 Senior Clinical Training Scholars over the years.

Oliver is a regular contributor to the RVC's schools outreach programme, including the 'RVC on Tour' and the BSc (Bioveterinary Sciences) Open Day for school children. He also volunteers for British Society for Immunology public engagement activities (e.g. The Secret Life of Snot at the Big Bang Fair, ExCel Centre, London). He passionately believes in the importance of clear communication of scientific issues to the greater public and his research was featured in a recent podcast ('RVC 50') and RVC Annual Research Highlights event. He has lectured to veterinarians and veterinary nurses in the UK, USA and Asia – both general practitioners and specialists.

Oliver's paper on the haematological phenotypes of different dog breeds, published in PLOS ONE, has been featured in a recent Press Release - RVC study provides large-scale analysis of blood cells in dog breeds. This work not only has immediate implications for canine medical practice, but also has far-reaching ramifications for our understanding of the genetic determinants of blood cells in health. This paper has been downloaded over 50 times from Oliver's ResearchGate page.

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