Department: Comparative Biomedical Sciences
Research Groups: Cardiovascular and Inflammation Biology and Metabolism
Jonathan Elliott is Vice-Principal for Research and Innovation and Professor of Veterinary Clinical Pharmacology.
As VP-R&I he has strategic responsibility for the Research mission of the College.
He chairs the College’s Research Strategy Committee and Safety Committee, is a Director of the London Bioscience Innovation Centre, is a member of the Bloomsbury Research Committee, Management Board for the London International Development Centre and of the London Interdisciplinary Doctoral Consortium (led by UCL) and as the College's Establishment Licence holder he chairs the Animal Welfare and Ethical Review Board.
Jonathan Elliott graduated from Cambridge University Veterinary School in 1985. After graduation, he completed an Internship at Veterinary Hospital University of Pennsylvania in Philadelphia in 1986, a PhD in vascular biology and amine oxidases at the University of Cambridge in 1989 and gained his RCVS Certificate in Small Animal Cardiology in 1990.
In 1990 he was appointed to a lectureship at the Royal Veterinary College in London where he is currently Professor in Veterinary Clinical Pharmacology and Vice Principal - Research. He was awarded the Pfizer Academic Award (1998) for his research contributions to the pathophysiology of laminitis and the BSAVA Amoroso award (2001), the PetPlan Scientific Award (2005) and the European Society of Nephrology and Urology Award (2007) all for his clinical research contributions in the area of feline chronic kidney disease. He is a Diplomate of the European College of Veterinary Pharmacology and Toxicology. He is President Elect of ECVPT
Professor Elliott is currently a member of:
- Petplan Charitable Trust Scientific Committee
- International Renal Interest Society
- World Small Animal Veterinary Association Renal Pathology Standardization Group
- The Board of the Veterinary Blood Pressure Society
Professor Elliott is a past member of the The Veterinary Products Committee and BBSRCs Training Awards Committee
Jonathan's research interests encompass the pathophysiology of renal, cardiac and vascular diseases of companion animals. He belongs to the Comparative Physiology & Medicine research programme.
Orcid ID: http://orcid.org/0000-0002-4517-6590
Williams, T L; Elliott, J; Syme, H M; Archer, J.
Investigation of the association between serum protein concentrations and concurrent chronic kidney disease in hyperthyroid cats.
RESEARCH IN VETERINARY SCIENCE, 115412-417. (2017)
Crossley, V J; Debnath, A; Chang, Y M; Fowkes, R; Elliott, J; Syme, H.
Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE, (2017)
Van Den Broek, H; Chang, Y M; Elliott, J; Jepson, R E.
Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia.
JOURNAL OF VETERINARY INTERNAL MEDICINE (2017)
Bijsmans, E S; Doig, M; Jepson, R E; Syme, H M; Elliott, J; Pelligand, L.
Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE, (2016).
Brown, C; Elliott, J; Schmiedt, C; Brown, S.
Chronic kidney disease in aged cats: Clinical features, morphology, and proposed pathogeneses.
VETERINARY PATHOLOGY, 2016. 53;2:309-326.
Jepson RE, Warren HR, Syme HM, Elliott J, Munroe PB. Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study. J Small Anim Pract. 2016 Nov;57(11):580-588.
Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635.
Cowgill LD, Polzin DJ, Elliott J, Nabity MB, Segev G, Grauer GF, Brown S, Langston C, van Dongen AM. Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury? Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):995-1013.
Vaden SL, Elliott J. Management of Proteinuria in Dogs and Cats with Chronic Kidney Disease. Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):1115-30.
Sanchez-Lara, AC; Elliott, J; Syme, HM; Brown, CA; Haylor, JL. Feline Chronic Kidney Disease Is Associated with Upregulation of Transglutaminase 2: A Collagen Cross-Linking Enzyme.
VETERINARY PATHOLOGY, 2015, 52;3:513-523. http://dx.doi.org/10.1177/0300985814542811
Lawson J, Elliott J, Wheeler-Jones C, Syme H, Jepson R. Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury. Vet J. 2015 Jan;203(1):18-26. http://dx.doi.org/10.1016/j.tvjl.2014.10.009
Kenward H, Pelligand L, Savary-Bataille K, Elliott J. Nausea: current knowledge of mechanisms, measurement and clinical impact. Vet J. 2015 Jan;203(1):36-43. http://dx.doi.org/10.1016/j.tvjl.2014.10.007
Lees P, Pelligand L, Elliott J, Toutain PL, Michels G, Stegemann M. Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review. J Vet Pharmacol Ther. 2015 Feb;38(1):1-14. http://dx.doi.org/10.1111/jvp.12185
Finch NC, Heiene R, Elliott J, Syme HM, Peters AM. Determination of extracellular fluid volume in healthy and azotemic cats. J Vet Intern Med. 2015 Jan;29(1):35-42. http://dx.doi.org/10.1111/jvim.12506
Chetboul, V; Reynolds, BS; Trehiou-Sechi, E; Nguyen, P; Concordet, D; Sampedrano, CC; Testault, I; Elliott, J; Abadie, J; Biourge, V; Lefebvre, HP. (2014)
Cardiovascular effects of dietary salt intake in aged healthy cats: a 2-year prospective randomized, blinded, and controlled study.
PLoS One, 9;6:e97862. http://dx.doi.org/10.1371/journal.pone.0097862
Lopez-Alvarez, J; Boswood, A; Moonarmart, W; Hezzell, M J; Lotter, N; Elliott, J. (2014)
Longitudinal Electrocardiographic Evaluation of Dogs with Degenerative Mitral Valve Disease.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28;2:393-400.
Kenward, H; Pelligand, L; Elliott, J. (2014)
Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.
EXPERIMENTAL BRAIN RESEARCH
http://dx.doi.org/10.1007/s00221-014-3961-6 [Epub ahead of print]
Menzies-Gow, N J; Wray, H; Bailey, S R; Harris, P A; Elliott, J. (2014)
The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies.
EQUINE VETERINARY JOURNAL, 46;3:317-321.
Jepson RE, Syme HM, Elliott J. (2014)
Plasma renin activity and aldosterone concentrations in hypertensive cats with and without azotemia and in response to treatment with amlodipine besylate.
JOURNAL OF VETERINARY INTERNAL MEDICINE. 2014 Jan-Feb;28(1):144-53.
Williams, TL; Elliott, J; Syme, HM. (2013)
Renin-Angiotensin-Aldosterone System Activity in Hyperthyroid Cats with and without Concurrent Hypertension..
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27;3:522-529.
Reynolds, B S; Chetboul, V; Nguyen, P; Testault, I; Concordet, D V; Sampedrano, C C; Elliott, J; Trehiou-Sechi, E; Abadie, J; Biourge, V; Lefebvre, H P. (2013)
Effects of Dietary Salt Intake on Renal Function: A 2-Year Study in Healthy Aged Cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27;3:507-515.
O'Neill, DG; Elliott, J; Church, DB; McGreevy, PD; Thomson, PC; Brodbelt, DC (2013)
Chronic Kidney Disease in Dogs in UK Veterinary Practices: Prevalence, Risk Factors, and Survival
JOURNAL OF VETERINARY INTERNAL MEDICINE. http://dx.doi.org/10.1111/jvim.12090
Finch N. C.; Syme H. M.; Elliott J. (2012)
Association of urinary cadmium excretion with feline hypertension
VETERINARY RECORD 170 (5), 125-U47 DOI: 10.1136/vr.100264
Pelligand L.; King J. N.; Toutain P. L.; Elliott, J; Lees, P (2012)
Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 35 (1): 19-32
Finch, NC; Syme, HM; Elliott, J; Peters, AM; Gerritsen, R; Croubels, S; Heine, R (2012)
Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats
Source: AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (12): 1652-1659
Wakeling, J; Elliott, J; Syme, H (2011)
Evaluation of Predictors for the Diagnosis of Hyperthyroidism in Cats
JOURNAL OF VETERINARY INTERNAL MEDICINE 25(5): 1057-1065
Jones, ID; Fuentes, VL; Wrigglesworth, D; Mort, E; Elliott, J (2011)
Comparison of flow-mediated vasodilation in femoral and brachial arteries in healthy dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH 72(8): 1029-1037
Pelligand, L; Lees, P; Elliott, J (2011)
Development and validation of a timed urinary collection system for use in the cat
LABORATORY ANIMALS 45 (3): 196-203 DOI: 10.1258/la.2011.
Katz, LM: Marr, CM; Elliott, J (2011)
Characterization of the responses of equine digital veins and arteries to calcitonin gene-related peptide
AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (7): 975-981
BROOKS, A.C.; MENZIES-GOW, N.J.; WHEELER-JONES, C.P.D.; BAILEY, S.R.; ELLIOTT, J.; CUNNINGHAM, F.M. (2009) Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. J vet Pharmacol Therap 32, 189-196. PubMed ID: 19290950
WAKELING, J., MOORE, K., ELLIOTT, J. & SYME, H. (2008) Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. J Small Anim Pract 49, 287-294. PubMed ID 18422499
MENZIES-GOW, N. J., SEPULVEDA, M. F., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2008) Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. Am J Vet Res 69, 199-207. PubMed ID 18241016
MENZIES-GOW, N. J., BAILEY, S. R., BERHANE, Y., BROOKS, A. C. & ELLIOTT, J. (2008) Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin. Am J Vet Res 69, 349-355. PubMed ID 18312133
BERHANE, Y., BAILEY, S. R., PUTIGNANO, C. & ELLIOTT, J. (2008) Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit. J Vet Pharmacol Ther 31, 1-8. PubMed ID 18177312
BAILEY, S. R., HABERSHON-BUTCHER, J. L., RANSOM, K. J., ELLIOTT, J. & MENZIES-GOW, N. J. (2008) Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am J Vet Res 69, 122-129. PubMed ID 18167097
ZERPA, H., BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2007) Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase. Eur J Pharmacol 569, 212-221. PubMed ID 17560569
SYME, H. M., FLETCHER, M. G., BAILEY, S. R. & ELLIOTT, J. (2007) Measurement of aldosterone in feline, canine and human urine. J Small Anim Pract 48, 202-208. PubMed ID 17381765
BROOKS, A. C., MENZIES-GOW, N. J., WHEELER-JONES, C., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2007) Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production. Inflamm Res 56, 154-161. PubMed ID 17522813
BAILEY, S. R., MENZIES-GOW, N. J., HARRIS, P. A., HABERSHON-BUTCHER, J. L., CRAWFORD, C., BERHANE, Y., BOSTON, R. C. & ELLIOTT, J. (2007) Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis. J Am Vet Med Assoc 231, 1365-1373. PubMed ID 17975996
BAILEY, S. R. & ELLIOTT, J. (2007) The corticosteroid laminitis story: 2. Science of if, when and how. Equine Vet J 39, 7-11. PubMed ID 17228587
ZERPA, H., BAILEY, S. R., BERHANE, Y. & ELLIOTT, J. (2006) Pharmacological characterization of alpha1-adrenoceptors in equine digital veins. J Vet Pharmacol Ther 29, 55-61. PubMed ID 16420303
SYME, H. M., MARKWELL, P. J., PFEIFFER, D. & ELLIOTT, J. (2006) Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. J Vet Intern Med 20, 528-535. PubMed ID 16734085
ELLIOTT, J. & SYME, H. M. (2006) Proteinuria in chronic kidney disease in cats--prognostic marker or therapeutic target? J Vet Intern Med 20, 1052-1053. PubMed ID 17063695
ELLIOTT, J. & BAILEY, S. R. (2006) Gastrointestinal derived factors are potential triggers for the development of acute equine laminitis. J Nutr 136, 2103S-2107S. PubMed ID 16772511
BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2006) Assessment of endothelium-dependent vasodilation in equine digital resistance vessels. J Vet Pharmacol Ther 29, 387-395. PubMed ID 16958783
MENZIES-GOW, N. J., BAILEY, S. R., STEVENS, K., KATZ, L., ELLIOTT, J. & MARR, C. M. (2005) Digital blood flow and plasma endothelin concentration in clinically endotoxemic horses. Am J Vet Res 66, 630-636. PubMed ID 15900943
BOTHAM, K. M., BRAVO, E., ELLIOTT, J. & WHEELER-JONES, C. P. (2005) Direct interaction of dietary lipids carried in chylomicron remnants with cells of the artery wall: implications for atherosclerosis development. Curr Pharm Des 11, 3681-3695. PubMed ID 16305504
MENZIES-GOW, N. J., BAILEY, S. R., KATZ, L. M., MARR, C. M. & ELLIOTT, J. (2004) Endotoxin-induced digital vasoconstriction in horses: associated changes in plasma concentrations of vasoconstrictor mediators. Equine Vet J 36, 273-278. PubMed ID 15147137
BERHANE, Y., BAILEY, S. R., HARRIS, P. A., GRIFFITHS, M. J. & ELLIOTT, J. (2004) In vitro and in vivo studies of homocysteine in equine tissues: implications for the pathophysiology of laminitis. Equine Vet J 36, 279-284. PubMed ID 15147138
BAILEY, S. R., MENZIES-GOW, N. J., MARR, C. M. & ELLIOTT, J. (2004) The effects of vasoactive amines found in the equine hindgut on digital blood flow in the normal horse. Equine Vet J 36, 267-272. PubMed ID 15147136
BAILEY, S. R., MARR, C. M. & ELLIOTT, J. (2004) Current research and theories on the pathogenesis of acute laminitis in the horse. Vet J 167, 129-142. PubMed ID 14975387
KATZ, L. M., MARR, C. M. & ELLIOTT, J. (2003) Characterisation of the response of equine digital arteries and veins to substance P. J Vet Pharmacol Ther 26, 361-368. PubMed ID 14633189
KATZ, L. M., MARR, C. M. & ELLIOTT, J. (2003) Characterization and comparison of the responses of equine digital arteries and veins to endothelin-1. Am J Vet Res 64, 1438-1443. PubMed ID 14620782
GOULTER, A. B., AVELLA, M., BOTHAM, K. M. & ELLIOTT, J. (2003) Chylomicron-remnant-like particles inhibit the basal nitric oxide pathway in porcine coronary artery and aortic endothelial cells. Clin Sci (Lond) 105, 363-371. PubMed ID 12757429
ELLIOTT, J., SYME, H. M., REUBENS, E. & MARKWELL, P. J. (2003) Assessment of acid-base status of cats with naturally occurring chronic renal failure. J Small Anim Pract 44, 65-70. PubMed ID 12622470
ELLIOTT, J., SYME, H. M. & MARKWELL, P. J. (2003) Acid-base balance of cats with chronic renal failure: effect of deterioration in renal function. J Small Anim Pract 44, 261-268. PubMed ID 12831103
ELLIOTT, J., BERHANE, Y. & BAILEY, S. R. (2003) Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets. Am J Vet Res 64, 1124-1131. PubMed ID 13677390
BAILEY, S. R., MARR, C. M. & ELLIOTT, J. (2003) Identification and quantification of amines in the equine caecum. Res Vet Sci 74, 113-118. PubMed ID 12589734
BAILEY, S. R., BAILLON, M. L., RYCROFT, A. N., HARRIS, P. A. & ELLIOTT, J. (2003) Identification of equine cecal bacteria producing amines in an in vitro model of carbohydrate overload. Appl Environ Microbiol 69, 2087-2093. PubMed ID 12676687
SYME, H. M., BARBER, P. J., MARKWELL, P. J. & ELLIOTT, J. (2002) Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation. J Am Vet Med Assoc 220, 1799-1804. PubMed ID 12092951
HORN, J., BAILEY, S., BERHANE, Y., MARR, C. M. & ELLIOTT, J. (2002) Density and binding characteristics of beta-adrenoceptors in the normal and failing equine myocardium. Equine Vet J 34, 411-416. PubMed ID 12117116
GOULTER, A. B., AVELLA, M. A., ELLIOTT, J. & BOTHAM, K. M. (2002) Chylomicron-remnant-like particles inhibit receptor-mediated endothelium-dependent vasorelaxation in pig coronary arteries. Clin Sci (Lond) 103, 451-460. PubMed ID 12401117
BAILEY, S. R., RYCROFT, A. & ELLIOTT, J. (2002) Production of amines in equine cecal contents in an in vitro model of carbohydrate overload. J Anim Sci 80, 2656-2662. PubMed ID 12413088
ELLIOTT, J., BARBER, P. J., SYME, H. M., RAWLINGS, J. M. & MARKWELL, P. J. (2001) Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases. J Small Anim Pract 42, 122-129. PubMed ID 11303854
Vet Compass Project Type: Cat
This project, funded by Ceva, estimated the
prevalence of,and risk-factorsfor chronic kidney disease in cats attending VetCompass-participating veterinary practices in the United Kingdom. As a second objective, the prevalence of hypertension ancurrent practices for measuring and treating hypertension were explored.