Zhangrui Cheng
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Dr Zhangrui Cheng is a Research Fellow in Reproduction, Veterinary Pharmacology and Bioinformatics.
Biography
I received a bachelor degree of veterinary medicine from Hunan Agricultural University (China) in 1982. After completing my MSc degree in Beijing Agricultural University and Chinese Academy of Agricultural Science (CAAS) in 1984, I worked in Lanzhou Institute of Animal Science and Veterinary Pharmaceuticals, CAAS as a research fellow for 8 years. I undertook a number of research projects, including “blood rheology and dynamics and their uses in veterinary medicine and traditional Chinese veterinary medicine”, “Developing the computer programme software for pharmacokinetics (PK) modelling and analysis” and “Epidemiological studies on reproductive diseases in dairy cows”.
In 1993, I moved to the Department of Veterinary Pharmacology, Glasgow University to undertake research leading to a PhD. My research work was to investigated 1) the PK/pharmacodynamics (PD) behaviours of some non-steroid anti-inflammatory drugs (NSAIDs) in plasma and inflammatory site using donkey, goat and sheep as models and 2) the cyclo-oxygenase isoenzyme selectivity of NSAIDs to determine the therapeutic and side effects of NSAIDs.
Since 1997, I have joined the Royal Veterinary College based on the Reproduction group in Hawkshead campus. Working with Professor DC Wathes, I have developed my knowledge and experience in reproductive physiology and nutrition with particular interests in effect of polyunsaturated fatty acid (PUFAs) supplementation on reproductive processes and diseases. I have also worked with Professor P Lees to investigate the PK/PD processes of NSAIDs and antimicrobial drugs in farm animals. Based on the requirements of the research activities, I have also developed my interests, knowledge and skills in molecular biology, applied statistics, functional genomics and bioinformatics.
Research
• The effect of PUFA supplementation on female reproductive processes (especially ovulation, luteolysis, pregnancy and parturition) and diseases (infection and immunization).
• PK and PD of antimicrobial and anti-inflammatory drugs in farm animals.
• Resistance of bacterial pathogens to antimicrobial drugs: mechanisms and avoidance.
• Gene expression patterns and pathways in female reproductive processes, diseases and treatments, and in the animals with stress.
Selected Publications
1. Murugan M, Fenwick M, Cheng Z, Sharma M, Singh D, and Wathes DC (2010) IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells. Reproduction, 139 (1), 139-151.
2. Wathes DC, Cheng Z, Chowdhury W, Fenwick M, Fitzpatrick R, Morris D, Patton J, and Murphy J (2009) Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows. Physiological Genomics, 39(1), 1-13.
3. Swali A, Cheng Z, Bourne N, Wathes DC (2008) metabolic traits affecting growth rates of pre-pubertal calves and their relationship with subsequent survival. Domestic Animal Endocrinology, 35, 300-313.
4. Childs S, Hennessy AA, Sreenan JM, Wathes DC, Cheng Z, Stanton C, Diskin MG and Kenny DA (2008) Effect of level of dietary n-3 polyunsaturated fatty acid supplementation on systemic and tissue fatty acid concentrations and on selected reproductive variables in cattle. Theriogenology, 70(4), 595-611.
5. Haworth GM, Tranter WP, Chuck JN, Cheng Z and Wathes DC (2008) Relationships between age at first calving and first lactation milk yield, and lifetime productivity and longevity in dairy cows. Veterinary Record, 162, 643-647.
6. Wathes DC, Fenwick M, Cheng Z, Bourne N, Llewellyn S, Morris DG, Kenny D, Murphy J and Fitzpatrick R (2007) Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow. Theriogenology, 68, Suppl 1, S232-241.
7. Wathes DC, Brickell JS, Bourne N, Swali A and Cheng Z (2007) Factors influencing heifer survival and fertility on commercial dairy farms (review). In 'Fertility in dairy cows : bridging the gaps'. Liverpool pp. 1135-1143. (Cambridge University Press).
8. Wathes DC, Bourne N, Cheng Z, Mann GE, Taylor VJ, Coffey MP (2007) Multiple Correlation Analyses of Metabolic and Endocrine Profiles with Fertility in Primiparous and Multiparous Cows. Journal of Dairy Science, 90(3)1310-1325
9. Wathes DC, Cheng Z, Bourne N, Taylor VJ, Coffey MP, Brotherstone S (2007) Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domestic Animal Endocrinology, 33, 203–225.
10. Cheng Z, Abayasekara DRE and Wathes DC (2005) The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells. Biochimica et Biophysica Acta, 1736, 128 – 135.
11. Cheng Z, Elmes M, Kirkup SE, Chin E, Abayasekara DRE and Wathes DC(2005) The effect of a diet supplemented with the n-6 polyunsaturated fatty acid (PUFA) linoleic acid on prostaglandin production in early and late pregnant ewes. Journal of Endocrinology, 184, 165-178.
12. Elmes M, Green LR, Poore K, Newman J, Burrage D, Abayasekara R, Cheng Z, Hanson MA and Wathes DC (2005) Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. Journal of Physiology, 562, 583-592.
13. Taylor VJ, Cheng Z, Pushpakumara PGA, Beever DE and Wathes DC (2004) Relationships between the plasma concentrations of insulin-like growth factor-I in dairy cows and their fertility and milk yield. Veterinary Record, 155, 583-588.
14. Elmes M, Tew P, Cheng Z, Kirkup SE, Abayasekara DR, Calder PC, Hanson MA, Wathes DC and Burdge GC (2004) The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. Biochimica et Biohpysica Acta, 1686, 139-47.
15. Cheng Z, Elmes M, Kirkup SE, Abayasekara DRE and Wathes DC (2004) Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes. Journal of Endocrinology, 182, 249-256.
16. Wathes DC, Taylor VJ, Cheng Z, Mann GE (2003) Follicle growth, corpus luteum function and their effects on embryo development in postpartum dairy cows. Reproduction Supplement, 61, 219-237.
17. Cheng Z, Elmes M, Abayasekara DRE and Wathes DC (2003) Effects of conjugated linoleic acid on prostaglandins produced by cells isolated from maternal intercotylrdonary endometrium, fetal allantochorion and amnion in late pregnant ewes. Biochimica et Biohpysica Acta, 1633, 170-178.
18. Cheng Z, Nolan A, Monteiro A and McKellar Q (2003) Enantioselective pharmacokinetics and cyclo-oxygenase inhibition of carprofen and carprofen enantiomers in sheep. Journal of Veterinary Pharmacology and Therapeutics, 26, 1-4.
19. Cheng Z, Nolan A and McKellar Q(2002) Anti-inflammatory effects of carprofen, carprofen enantiomers and NG-nitro-L-arginine methyl ester in sheep. American Journal of Veterinary Research, 63, 782-788.
20. Robinson RS, Pushpakumara PGA, Cheng Z, Peters AR, Abayasekara DRE and Wathes DC (2002). Effects of dietary polyunsaturated fatty acids on ovarian function in the lactating dairy cow. Reproduction, 124, 119-131.
21. Cheng Z, Robinson RS, Pushpakumara PG, Mansbridge RJ and Wathes DC (2001) Effect of dietary polyunsaturated fatty acids on uterine prostaglandin synthesis in the cow. Journal of Endocrinology, 171, 463-473.
22. Leung ST, Cheng Z, Sheldrick EL, Derecka K, Flint APF and Wathes, DC (2001) The effect of lipopolysaccharide and interleukins-1, -2 and –6 on oxytocin recpetor expression and prostaglandin production in bovine endometrium. Journal of Endocrinology,168, 497-508.
23. Wathes DC, Talor VJ and Cheng Z (2001) Metabolic interactions with fertility. Cattle Practice, 9, 291-296.
24. Wathes DC, Beever, DE, Cheng Z, Pushpakumara, PGA and Taylor VJ(2001) Lifetime organisation and management of reproduction in the dairy cow. In BSAS Occasional Publication 28 "Integrated management systems for livestock" pp59-69.
25. Wathes DC, Robinson RS, Pushpakumara A, Cheng Z and Abayasekara DRE (1998) Nutritional effects on reproductive performance in dairy cows. Cattle Practice, 6, 371-377.
26. Leven RA, Leung ST and Cheng Z (1998) The use of oxytocin to prevent retained placeta after induction with cloprostenol. Cattle Practice, 6, 291-296.
27. Cheng Z, Nolan A and McKellar Q(1998) Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal antiinflammatory drugs in sheep. Inflammation, 22, 353-366.
28. Cheng Z, McKellar Q and Nolan A (1998) Pharmacokinetic studies of flunixin meglumine and phenylbutazone in plasma, exudate and transudate in sheep. Journal of Veterinary Pharmacology and Therapeutics, 21, 315-321.
29. Cheng Z, Welsh E, Nolan A & McKellar Q (1997) Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats. Veterinary Record, 140, 40-43.
30. Cheng Z, McKellar Q, Nolan A & Lees P (1996) Pharmacokinetic and pharmacodynamic studies on flunixin meglumine in donkeys. Veterinary Research Communications, 20, 469-472. (Short Communication).
31. Cheng Z, Mckellar Q, Nolan A & Lees P (1996) Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in donkeys. Journal of Veterinary Pharmacology and Therapeutics, 19, 149-151. (Short Communication).
32. Ali BH, Cheng Z, Hadrami GEl, Bashir, AK & McKellar QA ( 1996 ) Comparative pharmacokinetics of paracetamol and its sulphate and glucuronides metabolites in desert camels and goats. Journal of Veterinary Pharmacology and Therapeutics, 19, 238-244.