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Michelangelo Campanella

Name: Dr Michelangelo Campanella
PharmD, PhD,MRPharmsS
Michelangelo Campanella
Post: Lecturer in Pharmacology
Department: Comparative Biomedical Sciences
Email: mcampanella@rvc.ac.uk
Tel: +44 (0)20 7468 5430
Address: Comparative Biomedical Sciences
The Royal Veterinary College
Royal College Street
London NW1 0TU
Research Group(s):

Michelangelo is currently holding a position of Lecturer in Pharmacology and is affiliated Principal Investigator to the Consortium for Mitochondrial Research (UCL) http://www.ucl.ac.uk/mitochondria/.

Focus of his research activity is to assess the functional role molecules in respect of the regulation of key mitochondrial enzymatic pathways and in the experimentation of strategies to target them and define novel pharmacological treatments.


Biography

Michelangelo (known as Miche) studied in Italy at the School of Pharmacy of the University of Ferrara where he obtained a degree as Doctor of Pharmacy. The course focused on the knowledge and clinical usage of therapeutics and the comprehension of their pharmacological basis and protocols of preparation.
In the last two years of his degree, Michelangelo joined the lab of Professor Rosario Rizzuto to undertake his undergraduate research project focused on the development and learning of luminescence based approaches to monitor Ca2+ and ATP signals in living cells. Prof. Rizzuto is one of the world experts in Ca2+ signalling who also has the merit of identifying mitochondria as a relevant pathway for the definition of Ca2+ homeostasis.
Michelangelo has also worked at the Columbia University of New York in the lab of Professor Eric Schon, a luminary figure engaged in the clarification of the mitochondrial genetic, who taught him the principles and the basal techniques of molecular biology.
Upon completion of his degree, Michelangelo registered to the Italian Pharmaceutical Society to practise as a Pharmacist.
Following a short period in practice, he began a PhD in Cellular and Molecular Pharmacology still under the supervision of Prof. Rizzuto. His PhD work was centred on the role of Ca2+ in programmed cell death. After concluding his PhD, Michelangelo was keen to undertake further training so he moved abroad and joined the lab of Professor Michael R Duchen at the University College London. Prof. Duchen is an eminent scientist renowned for his work on mitochondrial physiology and his unique competence of imaging techniques.
During his period at UCL Michelangelo received initial support from the Royal Society, Accademia dei Lincei and the European Molecular Biology Organization (EMBO) before being awarded of a Marie Curie Intra-European Fellowship which allowed him to complete a research period lasting 3 years. During this time he was also honoured of the opportunity to attend the Lindau meeting of Nobel prizes in Physiology as a young promising scientist in the field.
Michelangelo moved to the Royal Veterinary College in February 2008 as a Lecturer in Pharmacology and since June 2009 he has mecome also member of the Consortium for Mitochondrial research (CfMR) of the University College London as Affiliated Group Leader.
He is constantly requested as reviewer of high profile journals (e.g. Cell Death and Differentiation, JBC and Autophagy) and involved in editorial boards and roles (e.g. Cell Death and Disease, Autophagy, Frontiers,  Biochemical Journal, Current Molecular Medicine). More recently, for the constant engagement in relevant topics, he has been also named Local Ambassador of the Biochemical Society.
 

Research

In the recent years, the research activity of Dr Campanella and his collaborators has been dedicated to investigate fundamental concepts associated with the biology of mitochondria and lying at the basis of the whole cellular health: ENERGY and QUALITY. PATHWAYS and MOLECULES which can concomitantly impinge on both these aspects have been therefore objectives of his investigations aiming to provide information of vital aspects of normal and abnormal cell function.

Two principal lines of research foster his activity:
The molecular regulation of the reversion of the mitochondrial F1Fo-ATPsynthase in cell pathology and
II. The functional role of the mitochondrial Translocator Protein (mTSPO) in the upset of metabolism and self-conservation mechanisms guarding the cell integrity.
Dr Campanella has consolidated experience in cutting edge approaches in cell biology and his final aim is the identification of “drugable” molecular targets for a safety and efficiency pharmacological intervention in diseases associated to deregulation of QUALITY CONTROL MECCHANISMS and ENERGY METABOLISM.

Current Lab Members
The research unit directed by Dr Campanella is composed of young and talented scientists:

Dr Daniel East, PostDoc
Miss Jemma Gatliff, PhD Student
Mr Danilo Faccenda, PhDStudent
Dr Marta Mainenti, Research Associate

A long lasting collaboration of the Dr Campanella is with Prof. M. Duchen, Head of the CfMR UCL, whilst other ongoing collaborative work with clinicians at the Institute of Child Health (Dr. Paolo de Coppi) and at the Institute of Neurology UCL (Prof. Mike G. Hanna) with whom he is studying mitochondria function in stem cells and exploring the ATP consumption as pathogenetic mechanism in diseases of mitochondrial origin respectively.

He is also runnig collaborative work with Dr Geoff Wells and Dr Dr Andreas Schatzlein of the UCL School of Pharmacy on 

Teaching

Michelangelo is Leader of the Module in Pharmacology: Principles and Practice of the Bsc course. He is also responsible for the teaching of chemotherapy in the BVetMed course. He also lectures on the topic in the BSc (Hons) in Bioveterinary Sciences and Graduate Accelerated BVetMed course. 

Clinical

Michelangelo is focused in testing novel pharmacological compounds to tackle mitochondrial dysfunction associated to pathological conditions. He is regeistred Member of the General Pharmaceutical Council formed Royal Pharmaceutical Society which entitles to practice in the United Kingdom.

Selected Publications

•Andrea Repele, Ramona Lupi, Simon Eaton, Paolo De Coppi and Michelangelo Campanella. Fundamental Cell Biology sets the Differences between Subpopulations of Satellite Cells (SCs). BMC Cell Biology Journal. in press

•Marcin Chlystun; Michelangelo Campanella; Ah-Lai Law; Michael Duchen; Lux Fatimathas; Tim Levine; Volker Gerke; Stephen Moss. Regulation of Mitochondrial Morphogenesis by Annexin A6. Plos One in press.

•Choon H Tan, Danilo Faccenda, Andreas Seraphim, Michael R Duchen & Michelangelo Campanella. The F1Fo-ATPase endogenous inhibitor IF1 regulates Mitochondrial Commitment to Apoptosis. 2012 Cell Death and Differentiation ISSN: 1476-5403.

•Dhvanit I. Shah, Naoko Takahashi-Makise, Jeffrey D. Cooney, Liangtao Li, Iman J. Schultz, Eric L. Pierce, Anupama Narla, Shilpa M. Hattangadi, Nathaniel B. Langer, Wen Chen, Tamara A. Dailey, Amy E. Medlock, Slater N. Hurst, Danilo Faccenda, Jessica M. Wiwczar, Terence C. Law, Guillaume Vogin, Carlo Brugnara, Yi Zhou, Diane M. Ward, Benjamin L. Ebert, Nika N. Danial, & Michelangelo Campanella, Harry A. Dailey, Jerry Kaplan, Barry H. Paw. Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts. Nature. 2012 Nov 22;491(7425):608-12.

•Ludovico Iannetti, Maria Pia Paroli, Claudia Fabiani, Michelangelo Campanella, Paola Pivetti-Pezzi. Effects of Intravitreal Bevacizumab on Inflammatory Choroidal Neovascular Membrane. Eur J Ophthalmol. 2012 Aug 8:0. 

•Klionsky DJ ...Campanella M....Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy. 2012 Apr;8(4):445-544. 

•Faccenda D and Campanella, M. Molecular Regulation of the Mitochondrial F1Fo ATPsynthase: Physiological and Pathological Significance of the Inhibitor Factor 1 (IF1). Int J Cell Biol. 2012;2012:367934. 

•Campanella, M. Neurodegeneration abides by the laws of Mitochondrial Biology. European Journal of Neurodegenerative Diseases 2012 Sept. 1. 

•Varaa D.S., Campanella M. and Pula G. The NOX1-selectiveinhibitor 2- acetylphenothiazine inhibits superoxide ion generation in human platelets and impairs collagen-dependent thrombus formation. Br J Pharmacol. 2012 Aug 6. 

•Plun-Favreau H, Burchell VS, Holmström KM, Yao Z, Deas E, Cain K, Fedele V, Moisoi N, Campanella M, Miguel Martins L, Wood NW, Gourine AV, Abramov AY HtrA2 deficiency causes mitochondrial uncoupling through the F1F0-ATP synthase and consequent ATP depletion. Cell Death and Disease. 2012 Jun 28;3:e335.

•Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Tulchinsky E, Grose R, Campanella M, Jones C, Salomoni P. The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene. 2012 Apr 23. 

•Gatliff J and Campanella M. The 18Kda Translocator Protein (TSPO): a New Perspective in Mitochondrial Biology. Current Molecular Medicine 2012 Feb 23. 

•Severinatne M, Faccenda D, De Biase V & Campanella M. In Bcl-2 knock-down cells, PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase. Current Molecular Medicine 2012 Feb 17. 

•Campanella M. The Physiology and Pharmacology of the mitochondrial 18-Kd Translocator Protein (TSPO): an Emerging Molecular Target for Diagnosis and Therapy. Current Molecular Medicine 2012 Feb 17. 

•Iannetti L,Accorinti M,Malagola R,Bozzoni-Pantaleoni F,Da Dalt S,Nicoletti F, Gradini R,Traficante A, Campanella M, Pivetti-Pezzi P. Role of the intravitreal growth factors in the pathogenesis of idiopathic epiretinal membrane. Invest Ophthalmol Vis Sci. 2011 Jul;52:5786-9 PMID: 21693611. 

•Giordano Pula, Elena Garonna, Warwick B. Dunn, Michio Hirano, Giuseppe Pizzorno, Michelangelo Campanella, Edward L. Schwartz, Mahmoud H. el Kouni, Caroline P.D. Wheeler-Jones. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 Dec;30(12):2631-8. 


• Gastaldello A, Gami P, Callaghan H and Campanella M*. Ca2+ dependent autophagy is enhanced by the Pharmacological Agent PK11195. *Corresponding/Senior author. Autophagy. 2010 Jul 6;6(5).


• Hall A, Campanella M, Loesch A, Duchen M, and Unwin R. “Albumin endocytosis in OK cells exposed to rotenone: an 'OKay' model for the effects of mitochondrial dysfunction on the proximal tubule Nephron Physiol. 2010;115(2):p9-p19. Epub 2010 May 13.


• Pavlov E, Aschar-Sobbi R, Campanella M, Turner RJ, Gomez-Garcia MR, Abramov AY. Inorganic polyphosphate and energy metabolism in mammalian cells. Journal of Biological Chemistry 2010 Mar 26;285(13):9420-8. Epub 2010 Feb 2.


• Rossi CA, Pozzobon M, Ditadi A, Archacka K, Gastaldello A, Sanna M, Franzin C, Malerba A, Milan G, Cananzi M, Schiaffino S, Campanella M*, Vettor R, De Coppi P. Clonal characterization of muscle satellite cells: proliferation, metabolism and differentiation define an intrinsic heterogeneity. *Corresponding/Senior author, Plos One 2010 Jan 1;5(1):e8523.


• Ferrari D#, Pinton P#, Campanella M#, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R*. Functional and structural alterations in the Endoplasmic Reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. #Equally contributed,*Corresponding author. Biochem Biophys Res Commun. 2009 Nov 24. [Epub ahead of print]


• Campanella M, Parker N, Tan CH, Hall AM and Duchen MR. IF1: setting the pace of the F1Fo-ATP synthase. Trends in Biochemical Sciences (TiBs). 2009 Jul;34(7):343-50. Epub ahead of print 2009 Jun 24.


• Campanella M*, Seraphin A, Abeti R, Casswell E, Echave P and Duchen MR. IF1, the F1Fo-ATPsynthase endogenous regulator, defines mitochondrial volume fraction in HeLa cells by regulating basal autophagy. Biochimica and Biophysica Acta (BBA), 2009 May;1787(5):393-401. Epub ahead of print, 2009 Mar 5. *Corresponding author.


• Campanella M*, Szabadkai G and Rizzuto R. Modulation of Intracellular Ca2+ Signalling in HeLa Cells by the Apoptotic Cell Death Enhancer PK11195. Biochemical Pharmacology 2008 Dec 1;76(11):1628-36. Epub 2008 Oct 4. *Corresponding author.


• Campanella M, Farah Z, Casswell E, Chong S , Wieckowski MR , Abramov AY, Tinker A and Duchen MR. Regulation of Mitochondrial Structure and Function by the F(1)F(o)-ATPase Inhibitor Protein, IF(1). Cell Metabolism 2008 Jul;8(1):13-25.


• McKenzie M, Liolitsa D, Akinshina N, Campanella M, Sisodiya S, Hargreaves I, Nirmalananthan N, Sweeney MG, Abou-Sleiman PM, Wood NW, Hanna MG, Duchen MR. Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. Journal of Biological Chemistry, 2007 Dec 21;282(51):36845-52. Epub 2007 Oct 16.


• Hoyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Bianchi K, Fehrenbacher N, Elling F, Rizzuto R, Mathiasen IS, Jaattela M Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-ß and Bcl-2. Moll.Cell. 2007 Jan 26;25(2):193-205).


• Campanella M, Pinton P, Rizzuto R. Mitochondrial Ca2+ homeostasis in health and diseases. Biological Research, 2004;37(4):653-60.
 

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