Kathy Botham
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Kathy is a member of the Lifestyle research group and her recent research examines the interaction of dietary lipoproteins with cells of the vasculature and liver.
Biography
Kathy Botham graduated with a BSc(Hons) in Biochemistry from the University of Liverpool in 1969, and she obtained a PhD in Biochemistry from the same institution in 1972. After a period of three years in the United States working with Hector DeLuca on vitamin D metabolism, she returned to the UK to join the sterol metabolism group headed by Professor George Boyd at the University of Edinburgh.
In 1986, she joined the Royal Veterinary College as a Lecturer, and was appointed to a Chair in Biochemistry in August 2007. Kathy was awarded a DSc by the University of Liverpool in 2002 for her contribution to research in the field of cholesterol and lipoprotein metabolism. Her current research centres on the role of dietary fats and other factors in the development of atherosclerosis.
Research
Kathy is a member of the Lifestyle research group and her main research interest is lipid and lipoprotein metabolism. In particular Kathy is interested in the effects of dietary lipids on the initiation and development of atherosclerosis. This includes interaction of lipoproteins from the diet with cells of the vasculature; including macrophages, monocytes and endothelial cells and also with the liver.
Current projects focus on the influence of chylomicron remnants on monocyte activation, macrophage foam cell formation and endothelial cell function, and on the effects of oxidation of the lipoprotein particles. Kathy is currently collaborating with Istituto Superiore di Sanitá; in Rome, University of the Basque Country in Bilbao and Instituto de la Grasa in Seville. Kathy also collaborates within the RVC with Drs Charlotte Lawson & Caroline Wheeler-Jones on lipoprotein-cell interactions.
Teaching
Kathy teaches on the BVetMed Year 1 Alimentary module, the BVetMed Year 2 Principles of Science module and the BSc Bioveterinary Science Year 1 Gastrointestinal Tract and Regulation & control modules. She also plays a minor teaching role on the Graduate & Transfer and Gateway courses. In addition she acts as a supervisor on 2nd and 3rd year BSc Bioveterinary Science research projects.
Selected Publications
BRAVO, E., PALLESCHI, S. ROSSI, B., NAPOLITANO, M., TIANO, L., D'AMORE, E. AND BOTHAM,K.M. (2012) Coenzyme Q metabolism is disturbed in high fat diet-induced non alcoholic fatty liver disease in rats. Int. J. Mol. Sci. 2012, 13(2), 1644-1657; doi:10.3390/ijms13021644. PubMed ID 22408414
KLOP, B., PROCTOR, S., MAMO, J.C.L., BOTHAM, K.M. AND CASTRO CABEZAS, M. (2012) Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases. Int. J. Vasc. Med. 2012, Article ID 947417, doi:10.1155/2012/947417. PubMed ID 21961070
ARMENGOL LOPEZ, S., BOTHAM, K.M. AND LAWSON, C. (2012) The oxidative state of chylomicron remnants influences their modulation of human monocyte activation. Int. J. Vasc. Med. 2012 Article ID 942512 doi:10.1155/2012/942512. PubMed ID 21961069
GRAHAM, V.S., LAWSON, C., WHEELER-JONES, C.P.D, PERONA, J.S., RUIZ-GUTIERREZ, V. AND BOTHAM, K.M. (2012) Triacylglycerol-rich lipoproteins derived from olive oil modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: The potential role of oleanolic acid. Eur J Nutr, 21, 871-878. PubMed ID 21681438
BRAVO, E., PALLESCHI, S., ASPICHUETA, P, BUQUE,X., CANO, A., NAPOLITANO, M., OCHOA, B. AND BOTHAM K.M. (2011) High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway. Lipids in Health and Disease, 10,60 electronic version: http://www.lipidworld.com/content/10/1/60. PubMed ID 21504583
GARONNA, E., KATHLEEN M BOTHAM, K.M., BIRDSEY, G.M., RANDI, A.M., GONZALEZ-PEREZ, R.R. AND WHEELER-JONES, C.P.D. (2011) Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-oxygenase-2 with Pro-angiogenic Actions of Leptin on Human Endothelial Cells. PLoS ONE, 6:e18823. PubMed ID 2153319
GRAHAM, V.S., DI MAGGIO, P., ARMENGOL, S., LAWSON, C., WHEELER-JONES, C.P. AND BOTHAM, K.M. (2011) Inhibition of macrophage inflammatory cytokine secretion by chylomicron remnants is dependent on their uptake by the low density lipoprotein receptor. Biochim Biophys Acta Mol Cell Biol Lipids 1811, 209-220. PubMed ID 21145417
BENTLEY, C., HATHAWAY N., WIDDOWS, J., BEJTA, F., DE PASCALE, C., AVELLA, M., WHEELER-JONES, C.P.D., BOTHAM, K.M., LAWSON C. (2011) Influence of chylomicron remnants on human monocyte activation in vitro. Nutr. Metab. Cardiovasc. Dis. 21, 871-878. PubMed ID 20674313
BRAVO, E., NAPOLITANO, M. AND BOTHAM, K.M. (2010) Postprandial lipid metabolism: the missing link between lifestyle habits and the increasing incidence of metabolic diseases in Western Countries? The Open Translational Medicine Journal 2, 1-13.
LOPEZ-SOLDADO, I., AVELLA, M., BOTHAM, K.M. (2009) Differential influence of different dietary fatty acids on very low density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants. Metabolism: Clinical and Experimental 58, 186-PubMed ID: 19154951
SAFWAT, G.M., PISANO, S. D’AMORE, E, BORIONI, G., NAPOLITANO, M., KAMAL, A.A., BALLANTI, P., BOTHAM K.M., BRAVO, E. (2009) Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high fat diet in rats: Does Coenzyme Q monomethyl ether have a modulatory effect? Nutrition 25, 1157-1168. PubMed ID: 19592219
CANO, A. CIAFFONI, F., SAFWAT G.M., ASPICHUETA, P., OCHOA, B., BRAVO, E., BOTHAM, K.M. (2009) Hepatic very low density lipoprotein assembly is disturbed in a rat model of non alcoholic fatty liver disease: Is there a role for dietary Coenzyme Q? J. Applied Physiol. 107, 707-17. PubMed ID: 19608932
DE PASCALE, C., GRAHAM, V., FOWKES, R.C., WHEELER-JONES, C.P.D. and BOTHAM, K.M. (2009) Suppression of nuclear factor-kappaB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles. FEBS J. 276, 5689-5702. PubMed ID: 19725874
LOPEZ-SOLDADO, I., AVELLA, M., BOTHAM, K.M. (2009) Suppression of VLDL secretion by cultured hepatocytes incubated with chylomicron remnants enriched in n-3 polyunsaturated fatty acids is regulated by hepatic nuclear factor-4alpha. Biochim Biophys Acta 1791, 1181-1189. PubMed ID: 19699314
BOTHAM, K.M. (2008) Oxidation of chylomicron remnants and vascular dysfunction. Atherosclerosis Supplements 9, 57-61. PubMed ID: 18621590
PROCTOR, S.D., VINE, D.F., BOTHAM, K.M., MAMO, J.C.L. and CASTRO CABEZAS, M.C. (2008) Intestinal post-prandial chylomicrons: State of the Union between liver, gut and dyslipidemia? Future Lipidology, 3, 473-480.
PERONA, J. S., AVELLA, M., BOTHAM, K. M. & RUIZ-GUTIERREZ, V. (2008) Differential modulation of hepatic very low-density lipoprotein secretion by triacylglycerol-rich lipoproteins derived from different oleic-acid rich dietary oils. Br J Nutr 99, 29-36. PubMed ID 17651518
NAPOLITANO, M., DE PASCALE, C., WHEELER-JONES, C., BOTHAM, K. M. & BRAVO, E. (2007) Effects of lycopene on the induction of foam cell formation by modified LDL. Am J Physiol Endocrinol Metab 293, E1820-1827. PubMed ID 17911344
LOPEZ-SOLDADO, I., AVELLA, M. & BOTHAM, K. M. (2007) Comparison of the effects of dietary saturated, mono-unsaturated and polyunsaturated fatty acids on very-low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnant-like particles. Biochem Soc Trans 35, 440-441. PubMed ID 17511622
BOTHAM, K. M., MOORE, E. H., DE PASCALE, C. & BEJTA, F. (2007) The induction of macrophage foam cell formation by chylomicron remnants. Biochem Soc Trans 35, 454-458. PubMed ID 17511626
BEJTA, F., NAPOLITANO, M., BOTHAM, K. M. & BRAVO, E. (2007) Incorporation of lycopene into chylomicron remnant-like particles inhibits their uptake by HepG2 cells. Life Sci 80, 1699-1705. PubMed ID 17328921
BEJTA, F., MOORE, E. H., AVELLA, M., GOUGH, P. J., SUCKLING, K. E. & BOTHAM, K. M. (2007) Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processes. Biochim Biophys Acta 1771, 901-910. PubMed ID 17540618