Jonathan Elliott
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Jonathan Elliott is Vice Principal for Research and Innovation and Professor of Veterinary Clinical Pharmacology. He is a Diplomate of the European College of Veterinary Pharmacology and Toxicology. His research interests encompass the pathophysiology of renal, cardiac and vascular diseases of companion animals. He belongs to the Lifestyle research programme.
Biography
Jonathan Elliott graduated from Cambridge University Veterinary School in 1985. After graduation, he completed an Internship at Veterinary Hospital University of Pennsylvania in Philadelphia in 1986, a PhD in vascular biology and amine oxidases at the University of Cambridge in 1989 and gained his RCVS Certificate in Small Animal Cardiology in 1990.
In 1990 he was appointed to a lectureship at the Royal Veterinary College in London where he is currently Professor in Veterinary Clinical Pharmacology and Vice Principal - Research. He was awarded the Pfizer Academic Award (1998) for his research contributions to the pathophysiology of laminitis and the BSAVA Amoroso award (2001), the PetPlan Scientific Award (2005) and the European Society of Nephrology and Urology Award (2007) all for his clinical research contributions in the area of feline chronic kidney disease. He is a Diplomate of the European College of Veterinary Pharmacology and Toxicology.
Professor Elliott is currently a member of:
- Petplan Charitable Trust Scientific Committee
- International Renal Interest Society
- World Small Animal Veterinary Association Renal Pathology Standardization Group
- The Board of the Veterinary Blood Pressure Society
Professor Elliott is a past member of the The Veterinary Products Committee and BBSRCs Training Awards Committee
Research
Jonathan's research interests encompass the pathophysiology of renal, cardiac and vascular diseases of companion animals. He belongs to the Lifestyle Research Programme.
Selected Publications
Finch N. C.; Syme H. M.; Elliott J. (2012)
Association of urinary cadmium excretion with feline hypertension
VETERINARY RECORD 170 (5), 125-U47 DOI: 10.1136/vr.100264
PMID: 22141113
Pelligand L.; King J. N.; Toutain P. L.; Elliott, J; Lees, P (2012)
Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 35 (1): 19-32
DOI: 10.1111/j.1365-2885.2011.01288.x
PMID: 21767277
Finch, NC; Syme, HM; Elliott, J; Peters, AM; Gerritsen, R; Croubels, S; Heine, R (2012)
Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats
Source: AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (12): 1652-1659
PMID:22126694
Wakeling, J; Elliott, J; Syme, H (2011)
Evaluation of Predictors for the Diagnosis of Hyperthyroidism in Cats
JOURNAL OF VETERINARY INTERNAL MEDICINE 25(5): 1057-1065
DOI: 10.1111/j.1939-1676.2011.00790.x
PMID:21985139
Jones, ID; Fuentes, VL; Wrigglesworth, D; Mort, E; Elliott, J (2011)
Comparison of flow-mediated vasodilation in femoral and brachial arteries in healthy dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH 72(8): 1029-1037
PMID:21801059
Pelligand, L; Lees, P; Elliott, J (2011)
Development and validation of a timed urinary collection system for use in the cat
LABORATORY ANIMALS 45 (3): 196-203 DOI: 10.1258/la.2011.
PMID:21586514
Katz, LM: Marr, CM; Elliott, J (2011)
Characterization of the responses of equine digital veins and arteries to calcitonin gene-related peptide
AMERICAN JOURNAL OF VETERINARY RESEARCH 72 (7): 975-981
PMID: 21728859
BROOKS, A.C.; MENZIES-GOW, N.J.; WHEELER-JONES, C.P.D.; BAILEY, S.R.; ELLIOTT, J.; CUNNINGHAM, F.M. (2009) Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. J vet Pharmacol Therap 32, 189-196. PubMed ID: 19290950
WAKELING, J., MOORE, K., ELLIOTT, J. & SYME, H. (2008) Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. J Small Anim Pract 49, 287-294. PubMed ID 18422499
MENZIES-GOW, N. J., SEPULVEDA, M. F., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2008) Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. Am J Vet Res 69, 199-207. PubMed ID 18241016
MENZIES-GOW, N. J., BAILEY, S. R., BERHANE, Y., BROOKS, A. C. & ELLIOTT, J. (2008) Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin. Am J Vet Res 69, 349-355. PubMed ID 18312133
BERHANE, Y., BAILEY, S. R., PUTIGNANO, C. & ELLIOTT, J. (2008) Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit. J Vet Pharmacol Ther 31, 1-8. PubMed ID 18177312
BAILEY, S. R., HABERSHON-BUTCHER, J. L., RANSOM, K. J., ELLIOTT, J. & MENZIES-GOW, N. J. (2008) Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am J Vet Res 69, 122-129. PubMed ID 18167097
ZERPA, H., BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2007) Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase. Eur J Pharmacol 569, 212-221. PubMed ID 17560569
SYME, H. M., FLETCHER, M. G., BAILEY, S. R. & ELLIOTT, J. (2007) Measurement of aldosterone in feline, canine and human urine. J Small Anim Pract 48, 202-208. PubMed ID 17381765
BROOKS, A. C., MENZIES-GOW, N. J., WHEELER-JONES, C., BAILEY, S. R., CUNNINGHAM, F. M. & ELLIOTT, J. (2007) Endotoxin-induced activation of equine platelets: evidence for direct activation of p38 MAPK pathways and vasoactive mediator production. Inflamm Res 56, 154-161. PubMed ID 17522813
BAILEY, S. R., MENZIES-GOW, N. J., HARRIS, P. A., HABERSHON-BUTCHER, J. L., CRAWFORD, C., BERHANE, Y., BOSTON, R. C. & ELLIOTT, J. (2007) Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis. J Am Vet Med Assoc 231, 1365-1373. PubMed ID 17975996
BAILEY, S. R. & ELLIOTT, J. (2007) The corticosteroid laminitis story: 2. Science of if, when and how. Equine Vet J 39, 7-11. PubMed ID 17228587
ZERPA, H., BAILEY, S. R., BERHANE, Y. & ELLIOTT, J. (2006) Pharmacological characterization of alpha1-adrenoceptors in equine digital veins. J Vet Pharmacol Ther 29, 55-61. PubMed ID 16420303
SYME, H. M., MARKWELL, P. J., PFEIFFER, D. & ELLIOTT, J. (2006) Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. J Vet Intern Med 20, 528-535. PubMed ID 16734085
ELLIOTT, J. & SYME, H. M. (2006) Proteinuria in chronic kidney disease in cats--prognostic marker or therapeutic target? J Vet Intern Med 20, 1052-1053. PubMed ID 17063695
ELLIOTT, J. & BAILEY, S. R. (2006) Gastrointestinal derived factors are potential triggers for the development of acute equine laminitis. J Nutr 136, 2103S-2107S. PubMed ID 16772511
BERHANE, Y., ELLIOTT, J. & BAILEY, S. R. (2006) Assessment of endothelium-dependent vasodilation in equine digital resistance vessels. J Vet Pharmacol Ther 29, 387-395. PubMed ID 16958783
MENZIES-GOW, N. J., BAILEY, S. R., STEVENS, K., KATZ, L., ELLIOTT, J. & MARR, C. M. (2005) Digital blood flow and plasma endothelin concentration in clinically endotoxemic horses. Am J Vet Res 66, 630-636. PubMed ID 15900943
BOTHAM, K. M., BRAVO, E., ELLIOTT, J. & WHEELER-JONES, C. P. (2005) Direct interaction of dietary lipids carried in chylomicron remnants with cells of the artery wall: implications for atherosclerosis development. Curr Pharm Des 11, 3681-3695. PubMed ID 16305504
MENZIES-GOW, N. J., BAILEY, S. R., KATZ, L. M., MARR, C. M. & ELLIOTT, J. (2004) Endotoxin-induced digital vasoconstriction in horses: associated changes in plasma concentrations of vasoconstrictor mediators. Equine Vet J 36, 273-278. PubMed ID 15147137
BERHANE, Y., BAILEY, S. R., HARRIS, P. A., GRIFFITHS, M. J. & ELLIOTT, J. (2004) In vitro and in vivo studies of homocysteine in equine tissues: implications for the pathophysiology of laminitis. Equine Vet J 36, 279-284. PubMed ID 15147138
BAILEY, S. R., MENZIES-GOW, N. J., MARR, C. M. & ELLIOTT, J. (2004) The effects of vasoactive amines found in the equine hindgut on digital blood flow in the normal horse. Equine Vet J 36, 267-272. PubMed ID 15147136
BAILEY, S. R., MARR, C. M. & ELLIOTT, J. (2004) Current research and theories on the pathogenesis of acute laminitis in the horse. Vet J 167, 129-142. PubMed ID 14975387
KATZ, L. M., MARR, C. M. & ELLIOTT, J. (2003) Characterisation of the response of equine digital arteries and veins to substance P. J Vet Pharmacol Ther 26, 361-368. PubMed ID 14633189
KATZ, L. M., MARR, C. M. & ELLIOTT, J. (2003) Characterization and comparison of the responses of equine digital arteries and veins to endothelin-1. Am J Vet Res 64, 1438-1443. PubMed ID 14620782
GOULTER, A. B., AVELLA, M., BOTHAM, K. M. & ELLIOTT, J. (2003) Chylomicron-remnant-like particles inhibit the basal nitric oxide pathway in porcine coronary artery and aortic endothelial cells. Clin Sci (Lond) 105, 363-371. PubMed ID 12757429
ELLIOTT, J., SYME, H. M., REUBENS, E. & MARKWELL, P. J. (2003) Assessment of acid-base status of cats with naturally occurring chronic renal failure. J Small Anim Pract 44, 65-70. PubMed ID 12622470
ELLIOTT, J., SYME, H. M. & MARKWELL, P. J. (2003) Acid-base balance of cats with chronic renal failure: effect of deterioration in renal function. J Small Anim Pract 44, 261-268. PubMed ID 12831103
ELLIOTT, J., BERHANE, Y. & BAILEY, S. R. (2003) Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets. Am J Vet Res 64, 1124-1131. PubMed ID 13677390
BAILEY, S. R., MARR, C. M. & ELLIOTT, J. (2003) Identification and quantification of amines in the equine caecum. Res Vet Sci 74, 113-118. PubMed ID 12589734
BAILEY, S. R., BAILLON, M. L., RYCROFT, A. N., HARRIS, P. A. & ELLIOTT, J. (2003) Identification of equine cecal bacteria producing amines in an in vitro model of carbohydrate overload. Appl Environ Microbiol 69, 2087-2093. PubMed ID 12676687
SYME, H. M., BARBER, P. J., MARKWELL, P. J. & ELLIOTT, J. (2002) Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation. J Am Vet Med Assoc 220, 1799-1804. PubMed ID 12092951
HORN, J., BAILEY, S., BERHANE, Y., MARR, C. M. & ELLIOTT, J. (2002) Density and binding characteristics of beta-adrenoceptors in the normal and failing equine myocardium. Equine Vet J 34, 411-416. PubMed ID 12117116
GOULTER, A. B., AVELLA, M. A., ELLIOTT, J. & BOTHAM, K. M. (2002) Chylomicron-remnant-like particles inhibit receptor-mediated endothelium-dependent vasorelaxation in pig coronary arteries. Clin Sci (Lond) 103, 451-460. PubMed ID 12401117
BAILEY, S. R., RYCROFT, A. & ELLIOTT, J. (2002) Production of amines in equine cecal contents in an in vitro model of carbohydrate overload. J Anim Sci 80, 2656-2662. PubMed ID 12413088
ELLIOTT, J., BARBER, P. J., SYME, H. M., RAWLINGS, J. M. & MARKWELL, P. J. (2001) Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases. J Small Anim Pract 42, 122-129. PubMed ID 11303854