Harriet Syme
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Harriet is a Senior Lecturer in Small Animal Internal Medicine. She is currently director of the Royal Veterinary College’s Internal Medicine residency (SCTS) programme and supervises several PhD students working on clinically-based projects.
Biography
Harriet graduated from the Royal Veterinary College in 1994 and then completed a Junior Clinical Training Scholarship at the RVC. She went on to do a Small Animal Internship and then a Small Animal Medicine Residency at Purdue University in the USA from 1995 to 1999. She studied for a PhD at the RVC from 1999 to 2003. Harriet gained her Diplomate ACVIM in 1999 and her Diplomate ECVIM-CA in 2002.
She was awarded the International Renal Interest Society (IRIS) Award in 2002 for her contribution to the field of veterinary nephrology & urology and the Dame Olga Uvarov award for clinical research in 2008.
Research
Harriet’s main research interests are diseases of the geriatric cat; namely chronic kidney disease, hypertension and hyperthyroidism. She is also interested in urological diseases of dogs including urolithiasis and incontinence.
Teaching
The bulk of Harriet’s didactic teaching is to the third year BVetMed students in the urogenital system module. She also provides a small amount of teaching on other years of the BVetMed. Other teaching includes the taught-tracking courses on feline medicine, endocrine therapeutics and in the medicine module. IShe also runs a nephrology/urology module for the MVetMed course. In addition Harriet supervises a number of clinical research projects done by final-year elective students, masters students, PhD students and residents (SCTSs). It is this, one-to-one teaching, together with the informal teaching that is done while on clinics that she most enjoys.
Harriet is involved in some RVC CPD courses, both in the form of conventional lectures and also via the internet, mainly in the fields of nephrology/urology and endocrinology.
Clinical
Harriet enjoys all areas of clinical medicine but particularly nephrology, urology and endocrinology. She is particularly keen to increase the urology caseload through offerring minimally invasive techniques, including laser lithotripsy treatment of stones and endoscopic treatment of ectopic ureter.
Selected Publications
CHAKRABARTI S, SYME HM, ELLIOTT J. (2012) Clinicopathological variables predicting progression of azotemia in cats with chronic kidney disease. J Vet Intern Med. 26(2):275-81. PubMed ID 22269057.
DAVIES ES, VOLK HA, BEHR S, SUMMERS B, DE LAHUNTA A, SYME H, JULL P, GAROSI L. (2012) Porencephaly and hydranencephaly in six dogs. Vet Rec. 170(7):179. PubMed ID 22186380.
FINCH NC, SYME HM, ELLIOTT J. (2012) Association of urinary cadmium excretion with feline hypertension. Vet Rec. 170(5):125. PubMed ID 22141113.
BOWEN EJ, MUNDY P, TIVERS MS, SYME HM, MANTIS P, SMYTH B, BAINES SJ. (2012) Duodenal Brunner's gland adenoma causing chronic small intestinal obstruction in a dog. J Small Anim Pract. 53(2):136-9. PubMed ID : 22129371.
FINCH NC, SYME HM, ELLIOTT J, PETERS AM, GERRITSEN R, CROUBELS S, HEIENE R. (2011) Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats. Am J Vet Res. 72(12):1652-9.
PubMed ID : 22126694.
WAKELING J, ELLIOTT J, SYME H. (2011) Evaluation of predictors for the diagnosis of
hyperthyroidism in cats. J Vet Intern Med. 25(5):1057-65. PubMed ID : 21985139.
CRAWFORD C, KENNEDY-LYDON TM, CALLAGHAN H, SPROTT C, SIMMONS RL, SAWBRIDGE L, SYME HM, UNWIN RJ, WILDMAN SS, PEPPIATT-WILDMAN CM. (2011) Extracellular nucleotides affect pericyte-mediated regulation of rat in situ vasa recta diameter. Acta Physiol (Oxf). 202(3):241-51. PubMed ID : 21624094.
CONNOLLY DJ, HEZZELL MJ, FUENTES VL, CHANG YM, SWAN R, SYME HM. (2011)The effect of protease inhibition on the temporal stability of NT-proBNP in feline plasma at room temperature. J Vet Cardiol. 13(1):13-9. PubMed ID : 21296042.
SYME H. Hypertension in small animal kidney disease. (2011) Vet Clin North Am Small Anim Pract. 41(1):63-89. PubMed ID 21251511.
WILLIAMS TL, ELLIOTT J, SYME HM. (2010) Association of iatrogenic hypothyroidism
with azotemia and reduced survival time in cats treated for hyperthyroidism. J
Vet Intern Med. 24(5):1086-92. PubMed ID 20695989.
JEPSON RE, SYME HM, MARKWELL P, MIYAZAKI M, YAMASHITA T, ELLIOTT J. (2010) Measurement of urinary cauxin in geriatric cats with variable plasma creatinine concentrations and proteinuria and evaluation of urine cauxin-to-creatinine concentration ratio as a predictor of developing azotemia. Am J Vet Res. 71(8):982-7.
PubMed ID 20673100.
WILLIAMS TL, PEAK KJ, BRODBELT D, ELLIOTT J, SYME HM. (2010) Survival and the development of azotemia after treatment of hyperthyroid cats. J Vet Intern Med. 24(4):863-9. PubMed ID 20649748.
ROE KA, SYME HM, BROOKS HW. (2010) Congenital large intestinal hypoganglionosis in a domestic shorthair kitten. J Feline Med Surg. 12(5):418-20. PubMed ID 20417903.
JEPSON RE, VALLANCE C, SYME HM, ELLIOTT J. (2010) Assessment of urinary
N-acetyl-beta-D-glucosaminidase activity in geriatric cats with variable plasma
creatinine concentrations with and without azotemia. Am J Vet Res. 71(2):241-7.
PubMed ID 20113234.
WAKELING J, EVERARD A, BRODBELT D, ELLIOTT J, SYME H. (2009) Risk factors for feline hyperthyroidism in the UK. J Small Anim Pract. 50(8):406-14. PubMed ID19689668.
JEPSON RE, BRODBELT D, VALLANCE C, SYME HM, ELLIOTT J. (2009) Evaluation of predictors of the development of azotemia in cats. J Vet Intern Med. 23(4):806-13. PubMed ID 19566846.
WAKELING J, ELLIOTT J, PETRIE A, BRODBELT D, SYME HM. (2009) Urinary iodide
concentration in hyperthyroid cats. Am J Vet Res. 70(6):741-9. PubMed ID 19496664.
LALOR SM, CONNOLLY DJ, ELLIOTT J, SYME HM. (2009) Plasma concentrations of
natriuretic peptides in normal cats and normotensive and hypertensive cats with
chronic kidney disease. J Vet Cardiol. 11 Suppl 1:S71-9. PubMed ID 19398225.
CONNOLLY DJ, SOARES MAGALHAES RJ, FUENTES VL, BOSWOOD A, COLE G, BOAG A, SYME HM. (2009) Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. J Vet Cardiol. 11 Suppl 1:S41-50. PubMed ID 19394286.
KATHRANI A, STEINER JM, SUCHODOLSKI J, EASTWOOD J, SYME H, GARDEN OA, ALLENSPACH K. (2009) Elevated canine pancreatic lipase immunoreactivity concentration in dogs with inflammatory bowel disease is associated with a negative outcome. J Small Anim Pract. 50(3):126-32. PubMed ID 19261082.
SYME HM. (2009) Proteinuria in cats. Prognostic marker or mediator? J Feline Med
Surg. 11(3):211-8. PubMed ID 19237136.
WALKER DJ, ELLIOTT J, SYME HM. (2009) Urinary cortisol/cortisone ratios in hypertensive and normotensive cats. J Feline Med Surg. 11(6):442-8. PubMed ID 19058985.
WAKELING J, MOORE K, ELLIOTT J, SYME H. (2008) Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. J Small Anim Pract. 49(6):287-94. PubMed ID 18422499.
WAKELING J, SMITH K, SCASE T, KIRKBY R, ELLIOTT J, SYME H. (2007) Subclinical
hyperthyroidism in cats: a spontaneous model of subclinical toxic nodular goiter
in humans? Thyroid. 17(12):1201-9. PubMed ID 18177255.
JEPSON, R. E., SYME, H. M., VALLANCE, C. & ELLIOTT, J. (2008) Plasma asymmetric dimethylarginine, symmetric dimethylarginine, l-arginine, and nitrite/nitrate concentrations in cats with chronic kidney disease and hypertension. J Vet Intern Med 22, 317-324. PubMed ID 18371026
CONNOLLY, D. J., MAGALHAES, R. J., SYME, H. M., BOSWOOD, A., FUENTES, V. L., CHU, L. & METCALF, M. (2008) Circulating natriuretic peptides in cats with heart disease. J Vet Intern Med 22, 96-105. PubMed ID 18289295
SYME, H. M., FLETCHER, M. G., BAILEY, S. R. & ELLIOTT, J. (2007) Measurement of aldosterone in feline, canine and human urine. J Small Anim Pract 48, 202-208. PubMed ID 17381765
SYME, H. M. (2007) Cardiovascular and renal manifestations of hyperthyroidism. Vet Clin North Am Small Anim Pract 37, 723-743, vi. PubMed ID 17619008
NIESSEN, S. J., VOYCE, M. J., DE VILLIERS, L., HARGREAVES, J., BLUNDEN, A. S. & SYME, H. M. (2007) Generalised lymphadenomegaly associated with methimazole treatment in a hyperthyroid cat. J Small Anim Pract 48, 165-168. PubMed ID 17355609
JEPSON, R. E., ELLIOTT, J., BRODBELT, D. & SYME, H. M. (2007) Effect of control of systolic blood pressure on survival in cats with systemic hypertension. J Vet Intern Med 21, 402-409. PubMed ID 17552443
CHANDLER, M. L., ELWOOD, C., MURPHY, K. F., GAJANAYAKE, I. & SYME, H. M. (2007) Juvenile nephropathy in 37 boxer dogs. J Small Anim Pract 48, 690-694. PubMed ID 17727634
SYME, H. M., MARKWELL, P. J., PFEIFFER, D. & ELLIOTT, J. (2006) Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. J Vet Intern Med 20, 528-535. PubMed ID 16734085
ELLIOTT, J. & SYME, H. M. (2006) Proteinuria in chronic kidney disease in cats--prognostic marker or therapeutic target? J Vet Intern Med 20, 1052-1053. PubMed ID 17063695
ELLIOTT, J., SYME, H. M., REUBENS, E. & MARKWELL, P. J. (2003) Assessment of acid-base status of cats with naturally occurring chronic renal failure. J Small Anim Pract 44, 65-70. PubMed ID 12622470
ELLIOTT, J., SYME, H. M. & MARKWELL, P. J. (2003) Acid-base balance of cats with chronic renal failure: effect of deterioration in renal function. J Small Anim Pract 44, 261-268. PubMed ID 12831103
SYME, H. M., BARBER, P. J., MARKWELL, P. J. & ELLIOTT, J. (2002) Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation. J Am Vet Med Assoc 220, 1799-1804. PubMed ID 12092951
MATHUR, S., SYME, H., BROWN, C. A., ELLIOT, J., MOORE, P. A., NEWELL, M. A., MUNDAY, J. S., CARTIER, L. M., SHELDON, S. E. & BROWN, S. A. (2002) Effects of the calcium channel antagonist amlodipine in cats with surgically induced hypertensive renal insufficiency. Am J Vet Res 63, 833-839. PubMed ID 12061529
SYME, H. M., SCOTT-MONCRIEFF, J. C., TREADWELL, N. G., THOMPSON, M. F., SNYDER, P. W., WHITE, M. R. & OLIVER, J. W. (2001) Hyperadrenocorticism associated with excessive sex hormone production by an adrenocortical tumor in two dogs. J Am Vet Med Assoc 219, 1725-1728, 1707-1728. PubMed ID 11767922
ELLIOTT, J., BARBER, P. J., SYME, H. M., RAWLINGS, J. M. & MARKWELL, P. J. (2001) Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases. J Small Anim Pract 42, 122-129. PubMed ID 11303854
SYME, H. M. & SCOTT-MONCRIEFF, J. C. (1998) Chronic hypoglycaemia in a hunting dog due to secondary hypoadrenocorticism. J Small Anim Pract 39, 348-351. PubMed ID 9693421