Chantal Chenu
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Chantal is a Senior Lecturer in Bone Cell Biology in Veterinary Basic Sciences. Her research is focused on the regulatory and repair mechanisms of bone.
Biography
Chantal graduated from Lyon University with a degree in Biochemistry. She conducted her PhD research in Professor Dave Roodman‘s laboratory (San Antonio, TX, USA) on osteoclast differentiation from bone marrow. She then joined Professor Pierre Delmas’s group in Lyon (INSERM Unit 403, Lyon, France) where her work focused on the biochemical and functional characterization of several bone matrix proteins.
She obtained a senior research position with INSERM France in 1991 and started her own research group aimed at investigating the role of the nervous system in the control of bone development and turnover. She moved to the Royal Veterinary College in 2003 and obtained in 2006 a Senior Lectureship position in the department of Veterinary Basic Sciences at the RVC.
Research
Chantal’s research integrates a range of approaches to investigate the mechanisms by which skeletal innervation and angiogenesis regulate bone development, remodelling and repair. Her current research is focused on the interactions between the sympathic nervous system, the vasculature and skeletal cells during bone healing. She has recently developed another programme of research aimed at investigating the control of bone mass in relation to energy metabolism. Her aim is to decipher the physiological role of the energy sensor AMP-activated protein kinase (AMPK) in bone metabolism by using tissue specific AMPK knockout mice (in collaboration with Dr Marta Korbonits at Barts and the London Medical School and Dr Benoit Viollet in Paris). One important aspect of this work is the role of AMPK in the mechanism of action of anti-diabetic drugs in bone. Chantal is also actively involved in research on healing of osteoporotic fractures due to her collaboration with Prof David Marsh at the UCL, London.
Chantal's research is funded by the Wellcome Trust and Arthritis Research UK.
Chantal has served on the Editorial Board of Journal of Bone and Mineral Research and is a Review Editor of Frontiers in Bone Research.
Teaching
Chantal plays an active teaching role within the college lecturing on BSc Bioveterinary Science and Graduate & Transfer courses. She also teaches at the Institute of Orthopaedics and Musculoskeletal Science at UCL. She is the Leader for 2nd Year BSc Bioveterinary Sciences and in charge of the tutorial programme for this year.
Selected Publications
JEYABALAN J, SHAH M, VIOLLET B, CHENU C. AMP-activated protein kinase pathway and bone metabolism. J Endocrinol, 2011, 211:1-14. PMID:21903861
SHAH M, KOLA B, BATAVELJIC A, ARNETT T, VIOLLET B, SAXON L, KORBONITS M & CHENU C. (2010) AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass. Bone, I47: 309-319. PMID:20399918
MARENZANA, M. & CHENU, C. (2008) Sympathetic nervous system and bone adaptive response to its mechanical environment. J Musculoskelet Neuronal Interact 8, 111-120. PubMed ID 18622080
MARENZANA, M., DE SOUZA, R. L. & CHENU, C. (2007) Blockade of beta-adrenergic signaling does not influence the bone mechano-adaptive response in mice. Bone 41, 206-215. PubMed ID 17543595
BLIZIOTES, M., ESHLEMAN, A., BURT-PICHAT, B., ZHANG, X. W., HASHIMOTO, J., WIREN, K. & CHENU, C. (2006) Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells. Bone 39, 1313-1321. PubMed ID 16884969
GOMEZ, C., BURT-PICHAT, B., MALLEIN-GERIN, F., MERLE, B., DELMAS, P. D., SKERRY, T. M., VICO, L., MALAVAL, L. & CHENU, C. (2005) Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation. Dev Dyn 234, 393-403.PubMed ID 16145665
DE SOUZA, R. L., PITSILLIDES, A. A., LANYON, L. E., SKERRY, T. M. & CHENU, C. (2005) Sympathetic nervous system does not mediate the load-induced cortical new bone formation. J Bone Miner Res 20, 2159-2168. PubMed ID 16294269
BURT-PICHAT, B., LAFAGE-PROUST, M. H., DUBOEUF, F., LAROCHE, N., ITZSTEIN, C., VICO, L., DELMAS, P. D. & CHENU, C. (2005) Dramatic decrease of innervation density in bone after ovariectomy. Endocrinology 146, 503-510. PubMed ID 15498888
MERLE, B., ITZSTEIN, C., DELMAS, P. D. & CHENU, C. (2003) NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis. J Cell Biochem 90, 424-436. PubMed ID 14505357
ESPINOSA, L., PARET, L., OJEDA, C., TOURNEUR, Y., DELMAS, P. D. & CHENU, C. (2002) Osteoclast spreading kinetics are correlated with an oscillatory activation of a calcium-dependent potassium current. J Cell Sci 115, 3837-3848. PubMed ID 12235294
SERRE, C. M., FARLAY, D., DELMAS, P. D. & CHENU, C. (1999) Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers. Bone 25, 623-629. PubMed ID 10593406
CHENU, C., SERRE, C. M., RAYNAL, C., BURT-PICHAT, B. & DELMAS, P. D. (1998) Glutamate receptors are expressed by bone cells and are involved in bone resorption. Bone 22, 295-299. PubMed ID 9556127
RAYNAL, C., DELMAS, P. D. & CHENU, C. (1996) Bone sialoprotein stimulates in vitro bone resorption. Endocrinology 137, 2347-2354. PubMed ID 8641185
CHENU, C., IBARAKI, K., GEHRON ROBEY, P., DELMAS, P. D. & YOUNG, M. F. (1994) Cloning and sequence analysis of bovine bone sialoprotein cDNA: conservation of acidic domains, tyrosine sulfation consensus repeats, and RGD cell attachment domain. J Bone Miner Res 9, 417-421. PubMed ID 7514841
CHENU, C., COLUCCI, S., GRANO, M., ZIGRINO, P., BARATTOLO, R., ZAMBONIN, G., BALDINI, N., VERGNAUD, P., DELMAS, P. D. & ZALLONE, A. Z. (1994) Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells. J Cell Biol 127, 1149-1158. PubMed ID 7962073