Ali Fouladi-Nashta
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Ali is a member of the Reproduction Research Group. His research is based on oocyte biology and embryology of domesticated and farm animal species and uterine embryo interaction and mechanism of embryo implantation.
Biography
Ali trained as a Veterinarian in Tehran University and served for about 7 years as a Lecturer in Animal Reproduction before moving to the United Kingdom for further education. He gained his MSc in 1995 and PhD in 1999 from the University of Edinburgh in Scotland.
Ali undertook at PhD at the Roslin Institute where he worked alongside Professor Keith Campbell, creator of Dolly the cloned sheep from differentiated cells. Following this he moved on to undertake post-doctoral work at the University of Manchester, investigating the role of Leukaemia Inhibitory Factor with Sue Kimber. Subsequently he joined Nottingham University as a Research Fellow working with Professor Bob Webb to investigate the effects of diet on oocyte & embryo quality in lactating dairy cows.
In June 2006, Ali accepted a Lectureship position at the Royal Veterinary College (Department of Veterinary Basic Sciences). His research in the area of female reproduction continues.
Research
During his time at the Roslin Institute Ali's studies established that improvement in cytoplasmic maturation of bovine oocytes improves the rate of blastocyst development (Fouladi-Nashta et al., 1998, Biology of Reproduction 59: 255-262).
At the University of Manchester Ali investigated the role of leukaemia inhibitory factor (LIF) on implantation of embryos in mice. Using LIF gene knocked-out mice he showed misregulation of signalling mechanisms and absence of changes in the uterine endometrium associated uterine receptivity (Fouladi-Nashta et al., 2005, Developmental Biology, 281:1-21) resulting in infertility. They also demonstrated that LIF inhibitor can effectively inhibit its effects on decidualisation of uterine stroma cells (Fouladi-Nashta et al., 2004, Journal of Endocrinology, 181: 477-492).
Whilst at Nottingham University Ali investigated the effects of diet on oocyte and embryo quality in lactating dairy cows. Diets can modify the profiles of hormones and local production of growth factors thereby influencing reproductive function (Fouladi-Nashta et al., 2007, Biology of Reproduction 77: 9-17). He developed diets which can promote reproductive cyclicity and also increase pregnancy rate in post-calving dairy cows (Garnsworthy et al., 2008). He also developed a simple and fast but reliable technique for assessment of blastocysts (Reproductive BioMedicine Online, 2005, 10: 497-502).
Selected Publications
MAREI, W.F., WATHES, D.C. & FOULADI-NASHT, A.A. (2009) The effect of linolenic Acid on bovine oocyte maturation and development. Reproduction. 138: 771-81. PubMed ID: 19633135
FOULADI-NASHT, A.A.,WONNACOTT, K.E., GUTIERREZ, C.G, GONG, J.G., SINCLAIR, K.D., GARNSWORTH, P.C. & WEBB, R. (2009) Oocyte quality in lactating dairy cows fed on high levels of n-3 and n-6 fatty acids. Reproduction 138, 771-81. PubMed ID: 19633135
GARNSWORTH, P.C., FOULADI-NASHT, A.A., MANN, GE., SINCLAIR, K.D. & WEBB, R. (2009) Effect of dietary-induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows. Reproduction. 137, 759-68. PubMed ID: 19129370
FOULADI-NASHTA, A. A., MOHAMET, L., HEATH, J. K. & KIMBER, S. J. (2008) Interleukin 1 signaling is regulated by leukemia inhibitory factor (LIF) and is aberrant in Lif-/- mouse uterus. Biol Reprod 79, 142-153. PubMed ID 18337516
FOULADI-NASHTA, A. A., GUTIERREZ, C. G., GONG, J. G., GARNSWORTHY, P. C. & WEBB, R. (2007) Impact of dietary fatty acids on oocyte quality and development in lactating dairy cows. Biol Reprod 77, 9-17. PubMed ID 17344470
SINGH, R., FOULADI-NASHTA, A. A., LI, D., HALLIDAY, N., BARRETT, D. A. & SINCLAIR, K. D. (2006) Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem 99, 146-155. PubMed ID 16598758
FOULADI-NASHTA, A. A. & CAMPBELL, K. H. (2006) Dissociation of oocyte nuclear and cytoplasmic maturation by the addition of insulin in cultured bovine antral follicles. Reproduction 131, 449-460. PubMed ID 16514188
NICHOLAS, B., ALBERIO, R., FOULADI-NASHTA, A. A. & WEBB, R. (2005) Relationship between low-molecular-weight insulin-like growth factor-binding proteins, caspase-3 activity, and oocyte quality. Biol Reprod 72, 796-804. PubMed ID 15564596
FOULADI-NASHTA, A. A., JONES, C. J., NIJJAR, N., MOHAMET, L., SMITH, A., CHAMBERS, I. & KIMBER, S. J. (2005) Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Dev Biol 281, 1-21. PubMed ID 15848385
FOULADI-NASHTA, A. A., ALBERIO, R., KAFI, M., NICHOLAS, B., CAMPBELL, K. H. & WEBB, R. (2005) Differential staining combined with TUNEL labelling to detect apoptosis in preimplantation bovine embryos. Reprod Biomed Online 10, 497-502. PubMed ID 15901458
FOULADI NASHTA, A. A., ANDREU, C. V., NIJJAR, N., HEATH, J. K. & KIMBER, S. J. (2004) Role of leukemia inhibitor factor (LIF) in decidualisation of murine uterine stromal cells in vitro. J Endocrinol 181, 477-492. PubMed ID 15171696