Mother’s diet may have long term impact on child’s health, study suggests
1 July 2008
Mothers who eat an unhealthy diet during pregnancy may be putting their children at risk of developing long term, irreversible health issues including obesity, raised levels of cholesterol and blood sugar, according to research published today1. The study, carried out in rats and funded by the Wellcome Trust, suggests that the effect is even more pronounced in female offspring.
A study published last year carried out by the same team at the Royal Veterinary College, London, showed that rodents which ate a diet rich in fat, sugar and salt whilst pregnant were more likely to give birth to offspring that overate and had a preference for junk food when compared to the offspring of rats given regular feed.
Now, in a follow-up study published in The Journal of Physiology1, the researchers have shown that a mother's diet has an effect lasting beyond adolescence in the rats, even when the offspring were weaned off the junk food, affecting how their bodies metabolise the food and suggesting a long term health impact.
Dr Stephanie Bayol and her colleague Professor Neil Stickland compared the offspring of rats fed a diet of processed junk food such as doughnuts, muffins, biscuits, crisps and sweets during pregnancy and lactation, and compared their offspring with those fed a healthy diet of regular feed.
The offspring of the mothers fed junk food diets had raised levels of cholesterol as well as higher levels of triglycerides, a type of fat found in the bloodstream. Both are known to increase the risk of developing heart disease. Similarly, the offspring had higher levels of glucose and insulin, both of which increase the likelihood of developing type 2 diabetes.
The researchers studied the rats beyond adolescence through to adulthood and observed that the rats were still fatter than those whose mothers had eaten a healthier diet whilst pregnant and breastfeeding. Crucially, this partly manifested itself as increased fat mass surrounding the kidneys relative to body mass; this so-called perirenal fat is also involved in the development of insulin resistance and type 2 diabetes.
"It seems that a mother's diet whilst pregnant and breastfeeding is very important for the long term health of her child," says Dr Bayol. "We always say 'you are what you eat'. In fact, it may also be true that 'you are what your mother ate.' This does not mean that obesity and poor health is inevitable and it is important that we take care of ourselves and live a healthy lifestyle. But it does mean that mothers must eat responsibly whilst pregnant."
Although the study was only carried out in rats, Professor Stickland believes the findings are likely to be applicable to humans. A 2007 US study published in the American Journal of Obstetrics & Gynecology2 showed that the more weight that pregnant women put on, the higher the risk that the child would be obese children. A 2005 British Medical Journal3 study also showed a correlation between parental and child weight.
"Humans share a number of fundamental biological systems with rats, so there is good reason to assume the effects we see in rats may be repeated in humans," he says. "Our research certainly tallies with epidemiological studies linking children's weight to that of their parents."
One surprising find from the study was how the maternal diet disrupted the offspring's metabolism: male offspring whose mothers had gorged on junk food had higher levels of insulin and normal levels of glucose, whilst the opposite was true for female offspring, who also tended to be fatter.
In addition, female offspring showed higher levels of leptin, a hormone related to appetite. It is already known that female appetite is more sensitive to leptin and male appetite to insulin, both of which the body can become resistant to. This suggests that metabolism is different for the two sexes and that the offspring's bodies will have a tendency towards over-eating.
"Obesity has increased dramatically over the last few years and needs to be tackled urgently," says Dr Pat Goodwin, Head of Pathogens, Immunology and Population Health at the Wellcome Trust. "This study supports the idea that there are many different risk factors that can lead to someone being overweight and developing related health problems. Pregnancy can be a difficult time for many mothers, but it is important that they are aware that what they eat may affect their offspring."
The Wellcome Trust
Contact: Craig Brierley, Media Officer, Tel: +44 (0)20 7611 7329
c.brierley@wellcome.ac.uk
You may also be interested in the RVC Podcast Episode 11 - Fetal Programming (17.5MB MPEG-4) in which Stephanie Bayol and Neil Stickland discuss their research with Matthias Kleinz (published 17 August 2007). You can also download or subscribe to the RVC Podcast via the iTunes Music Store
References:
- Bayol, S. et al. Offspring from mothers fed a “junk food” diet in pregnancy and lactation exhibit exacerbated adiposity which is more pronounced in females. Journal of Physiology, published 1 July 2008.
- Oken, E. et al. Gestational weight gain and child adiposity at age 3 years. American Journal of Obstetrics & Gynecology, April 2007.
- Reilly, J. et al. Early life risk factors for obesity in childhood: cohort study. British Medical Journal, published online 20 May 2005.
Notes for editors:
- The Royal Veterinary College is the UK's first and largest veterinary school and a constituent College of the University of London. The College is one of the leading veterinary research centres in Europe and received 5 out of 5 in the latest Research Assessment Exercise. It also provides support for veterinary and related professions through its three referral hospitals, diagnostic services and continuing professional development courses.
- The Wellcome Trust is the largest charity in the UK. It funds innovative biomedical research, in the UK and internationally, spending around £650 million each year to support the brightest scientists with the best ideas. The Wellcome Trust supports public debate about biomedical research and its impact on health and wellbeing. www.wellcome.ac.uk
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